Recent Advances in Glutathione Depletion-Enhanced Porphyrin-Based nMOFs for Photodynamic Therapy DOI Creative Commons
Bin Gong, Qiuyun Zhang, Jiayi Chen

и другие.

Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 244 - 244

Опубликована: Фев. 12, 2025

Photodynamic therapy has established itself as a clinical treatment for certain superficial cancers by converting oxygen into cytotoxic singlet to eradicate cancer cells. Porphyrin-based nanoscale metal-organic frameworks have emerged promising photosensitive platforms due their ability prevent the hydrophobic aggregation quenching of porphyrin molecules and enhance accumulation at tumor site, thereby becoming focal point in photodynamic materials research. However, elevated levels glutathione other reductive substances within cells can alleviate oxidative stress induced from process, thus protecting intracellular biomolecular structures damage. Consequently, it is crucial design functionalized nanoplatforms that integrate depletion with porphyrin-based significantly boost efficacy. Moreover, excess disrupt structure frameworks, which not only increases capacity generate upon light exposure but also aids recovery fluorescence imaging capabilities. Additionally, this specificity minimizes photosensitizing harm normal tissues. This review compiles recent advancements developing enhanced phototherapy through depletion. It aims promote further application provide valuable insights preclinical applications. By highlighting strategies improve therapeutic outcomes while maintaining safety profiles, summary seeks advance development more effective targeted treatments.

Язык: Английский

Recent Advances in Glutathione Depletion-Enhanced Porphyrin-Based nMOFs for Photodynamic Therapy DOI Creative Commons
Bin Gong, Qiuyun Zhang, Jiayi Chen

и другие.

Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 244 - 244

Опубликована: Фев. 12, 2025

Photodynamic therapy has established itself as a clinical treatment for certain superficial cancers by converting oxygen into cytotoxic singlet to eradicate cancer cells. Porphyrin-based nanoscale metal-organic frameworks have emerged promising photosensitive platforms due their ability prevent the hydrophobic aggregation quenching of porphyrin molecules and enhance accumulation at tumor site, thereby becoming focal point in photodynamic materials research. However, elevated levels glutathione other reductive substances within cells can alleviate oxidative stress induced from process, thus protecting intracellular biomolecular structures damage. Consequently, it is crucial design functionalized nanoplatforms that integrate depletion with porphyrin-based significantly boost efficacy. Moreover, excess disrupt structure frameworks, which not only increases capacity generate upon light exposure but also aids recovery fluorescence imaging capabilities. Additionally, this specificity minimizes photosensitizing harm normal tissues. This review compiles recent advancements developing enhanced phototherapy through depletion. It aims promote further application provide valuable insights preclinical applications. By highlighting strategies improve therapeutic outcomes while maintaining safety profiles, summary seeks advance development more effective targeted treatments.

Язык: Английский

Процитировано

0