Resveratrol-Loaded Solid Lipid Nanoparticles Reinforced Hyaluronic Hydrogel: Multitarget Strategy for the Treatment of Diabetes-Related Periodontitis DOI Creative Commons
Raffaele Conte, Anna Valentino,

Fabrizia Sepe

и другие.

Biomedicines, Год журнала: 2025, Номер 13(5), С. 1059 - 1059

Опубликована: Апрель 27, 2025

Background/Objectives: Periodontitis and diabetes mellitus share a well-established bidirectional relationship, where hyperglycemia exacerbates periodontal inflammation, disease further impairs glycemic control. Within the diabetic microenvironment, an imbalance between pro-inflammatory (M1) anti-inflammatory (M2) macrophages promotes chronic oxidative stress, delayed healing, alveolar bone resorption. Resveratrol (RSV), polyphenol with antioxidant, anti-inflammatory, pro-osteogenic properties, holds potential to restore macrophage balance. However, its clinical application is limited by poor bioavailability instability. This study aimed develop evaluate novel RSV delivery system overcome these limitations promote tissue regeneration under conditions. Methods: A drug comprising RSV-loaded solid lipid nanoparticles embedded within cross-linked hyaluronic acid hydrogel (RSV@CLgel) was formulated. The tested hyperglycemic inflammatory conditions for effects on polarization, cytokine expression, mitochondrial function, osteoblast differentiation. Results: RSV@CLgel effectively suppressed cytokines (TNF-α, IL-1β, IL-6) while upregulating markers (IL-10, TGF-β). It significantly reduced stress decreasing ROS peroxidation levels improved function antioxidant enzyme activity. Furthermore, enhanced differentiation, as evidenced increased ALP activity, calcium nodule formation, upregulation of osteogenic genes (COL-I, RUNX2, OCN, OPN). also inhibited RANKL-induced osteoclastogenesis, contributing preservation. Conclusions: presents promising multifunctional strategy management periodontitis. By modulating immune responses, reducing promoting regeneration, addresses key pathological aspects diabetes-associated disease.

Язык: Английский

Resveratrol-Loaded Solid Lipid Nanoparticles Reinforced Hyaluronic Hydrogel: Multitarget Strategy for the Treatment of Diabetes-Related Periodontitis DOI Creative Commons
Raffaele Conte, Anna Valentino,

Fabrizia Sepe

и другие.

Biomedicines, Год журнала: 2025, Номер 13(5), С. 1059 - 1059

Опубликована: Апрель 27, 2025

Background/Objectives: Periodontitis and diabetes mellitus share a well-established bidirectional relationship, where hyperglycemia exacerbates periodontal inflammation, disease further impairs glycemic control. Within the diabetic microenvironment, an imbalance between pro-inflammatory (M1) anti-inflammatory (M2) macrophages promotes chronic oxidative stress, delayed healing, alveolar bone resorption. Resveratrol (RSV), polyphenol with antioxidant, anti-inflammatory, pro-osteogenic properties, holds potential to restore macrophage balance. However, its clinical application is limited by poor bioavailability instability. This study aimed develop evaluate novel RSV delivery system overcome these limitations promote tissue regeneration under conditions. Methods: A drug comprising RSV-loaded solid lipid nanoparticles embedded within cross-linked hyaluronic acid hydrogel (RSV@CLgel) was formulated. The tested hyperglycemic inflammatory conditions for effects on polarization, cytokine expression, mitochondrial function, osteoblast differentiation. Results: RSV@CLgel effectively suppressed cytokines (TNF-α, IL-1β, IL-6) while upregulating markers (IL-10, TGF-β). It significantly reduced stress decreasing ROS peroxidation levels improved function antioxidant enzyme activity. Furthermore, enhanced differentiation, as evidenced increased ALP activity, calcium nodule formation, upregulation of osteogenic genes (COL-I, RUNX2, OCN, OPN). also inhibited RANKL-induced osteoclastogenesis, contributing preservation. Conclusions: presents promising multifunctional strategy management periodontitis. By modulating immune responses, reducing promoting regeneration, addresses key pathological aspects diabetes-associated disease.

Язык: Английский

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