Cascade Production of In Situ Oxygen and Singlet Oxygen from Self-Assembled Nanophotosensitizer for Anti-Hypoxic Photodynamic Therapy DOI
Ran Bai,

Linfang Yang,

Mingxuan Jia

и другие.

Nano Letters, Год журнала: 2025, Номер unknown

Опубликована: Апрель 18, 2025

Photosensitizers (PSs) capable of in situ oxygen (O2) production are attractive for overcoming hypoxia photodynamic therapy (PDT). However, these PSs generally require multiple components and complex fabrication procedures, preventing their clinical translation. Herein, we develop a single-component nanophotosensitizer via simple self-assembly that enables cascade O2 singlet (1O2) superior antibacterial PDT (aPDT). Perylene tetracarboxylic acid (PTA) molecules self-assemble into nanophotosensitizers (PTA NPs). Mechanism studies reveal dual functionality PTA NPs due to antiparallel-displaced π-π stacking. Aggregated undergo intermolecular electron transfer yield substantial photogenerated holes, while unimolecular undergoes intersystem crossing produce triplet PS (3PS*). These holes effectively oxidize water situ, which then participates downstream photosensitization with 3PS* 1O2. This reaction affords continuous supply efficient 1O2 production, enabling 63.07% higher rate compared the antibiotic vancomycin.

Язык: Английский

Cascade Production of In Situ Oxygen and Singlet Oxygen from Self-Assembled Nanophotosensitizer for Anti-Hypoxic Photodynamic Therapy DOI
Ran Bai,

Linfang Yang,

Mingxuan Jia

и другие.

Nano Letters, Год журнала: 2025, Номер unknown

Опубликована: Апрель 18, 2025

Photosensitizers (PSs) capable of in situ oxygen (O2) production are attractive for overcoming hypoxia photodynamic therapy (PDT). However, these PSs generally require multiple components and complex fabrication procedures, preventing their clinical translation. Herein, we develop a single-component nanophotosensitizer via simple self-assembly that enables cascade O2 singlet (1O2) superior antibacterial PDT (aPDT). Perylene tetracarboxylic acid (PTA) molecules self-assemble into nanophotosensitizers (PTA NPs). Mechanism studies reveal dual functionality PTA NPs due to antiparallel-displaced π-π stacking. Aggregated undergo intermolecular electron transfer yield substantial photogenerated holes, while unimolecular undergoes intersystem crossing produce triplet PS (3PS*). These holes effectively oxidize water situ, which then participates downstream photosensitization with 3PS* 1O2. This reaction affords continuous supply efficient 1O2 production, enabling 63.07% higher rate compared the antibiotic vancomycin.

Язык: Английский

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