Biomaterials, Год журнала: 2025, Номер unknown, С. 123422 - 123422
Опубликована: Май 1, 2025
Язык: Английский
Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер unknown, С. 114668 - 114668
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2025, Номер 32, С. 101781 - 101781
Опубликована: Апрель 17, 2025
Depression and cognitive disorders remain major challenges in healthcare, with conventional treatments often facing limitations such as slow onset, side effects, poor drug delivery to the brain. Biomimetic nanodelivery systems, including nanozymes, cell membrane-based exosomes, have emerged promising solutions these issues. These systems leverage natural biological processes enhance targeting, improve bioavailability, regulate complex pathways. Nanoenzymes, their catalytic properties, offer antioxidant anti-inflammatory benefits, while membranes exosomes provide efficient targeting immune evasion. However, remain, immaturity of large-scale production techniques, stability concerns, incomplete understanding mechanisms action. Moreover, long-term safety, pharmacokinetics, toxicity require further investigation. Despite obstacles, potential biomimetic revolutionize depression treatment is significant. Future research should focus on optimizing preparation, improving release, ensuring clinical safety. Multidisciplinary collaboration will be essential for advancing from laboratory practice, offering new therapeutic avenues other neurological disorders.
Язык: Английский
Процитировано
0
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Май 3, 2025
The blood-brain barrier (BBB) presents a formidable challenge in neuropharmacology, limiting the delivery of therapeutic agents to brain. Exosomes, nature's nanocarriers, have emerged as promising solution due their biocompatibility, low immunogenicity, and innate ability traverse BBB. A thorough examination BBB anatomy physiology reveals complexities neurological drug underscores limitations conventional methods. This review explores potential exosome-powered neuropharmaceutics, highlighting structural functional properties, biogenesis, mechanisms release. Their intrinsic advantages delivery, including enhanced stability efficient cellular uptake, are discussed detail. Exosomes naturally overcome barriers through specific translocation mechanisms, making them compelling vehicle for targeted brain therapies. Advances engineering strategies, such genetic biochemical modifications, loading techniques, specificity enhancement, further bolster potential. Exosome-based approaches hold immense promise treating spectrum disorders, Alzheimer's, Parkinson's, amyotrophic lateral sclerosis (ALS), multiple (MS), tumors, stroke, psychiatric conditions. By leveraging properties innovations, exosomes offer versatile platform precision neurotherapeutics. Despite promise, challenges remain clinical translation, large-scale production, standardization, regulatory considerations. Future research directions exosome nanobiotechnology aim refine these unlocking new avenues diseases. transformative impact exosome-based paving way next-generation therapies that can effectively penetrate revolutionize neuropharmacology.
Язык: Английский
Процитировано
0
Biomaterials, Год журнала: 2025, Номер unknown, С. 123422 - 123422
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0