Abstract
Alzheimer’s
disease
is
the
most
common
form
of
dementia
in
western
world,
however
there
no
cure
available
for
this
devastating
neurodegenerative
disorder.
Despite
clinical
and
experimental
evidence
implicating
intestinal
microbiota
a
number
brain
disorders,
its
impact
on
not
known.
To
end
we
sequenced
bacterial
16S
rRNA
from
fecal
samples
Aβ
precursor
protein
(APP)
transgenic
mouse
model
found
remarkable
shift
gut
as
compared
to
non-transgenic
wild-type
mice.
Subsequently
generated
germ-free
APP
mice
drastic
reduction
cerebral
amyloid
pathology
when
control
with
microbiota.
Importantly,
colonization
conventionally-raised
increased
pathology,
while
was
less
effective
increasing
levels.
Our
results
indicate
microbial
involvement
development
Abeta
suggest
that
may
contribute
diseases.
British Journal Of Nutrition,
Год журнала:
2015,
Номер
114(7), С. 999 - 1012
Опубликована: Июль 31, 2015
The
importance
of
chronic
low-grade
inflammation
in
the
pathology
numerous
age-related
conditions
is
now
clear.
An
unresolved
inflammatory
response
likely
to
be
involved
from
early
stages
disease
development.
present
position
paper
most
recent
a
series
produced
by
International
Life
Sciences
Institute's
European
Branch
(ILSI
Europe).
It
co-authored
speakers
2013
workshop
led
Obesity
and
Diabetes
Task
Force
entitled
'Low-grade
inflammation,
high-grade
challenge:
biomarkers
modulation
dietary
strategies'.
latest
research
areas
acute
cardiometabolic,
gut
cognitive
health
presented
along
with
cellular
molecular
mechanisms
underlying
inflammation-health/disease
associations.
evidence
relating
diet
composition
early-life
nutrition
status
reviewed.
Human
epidemiological
intervention
data
are
thus
far
heavily
reliant
on
measurement
markers
circulation,
particular
cytokines
fasting
state,
which
recognised
as
an
insensitive
highly
variable
index
tissue
inflammation.
Potential
novel
kinetic
integrated
approaches
capture
humans
discussed.
Such
provide
more
discriminating
means
quantifying
associations,
ability
positively
modulate
much
needed
develop
portfolios
that
will
inform
new
product
development
associated
claims.
Abstract
Alzheimer’s
disease
is
the
most
common
form
of
dementia
in
western
world,
however
there
no
cure
available
for
this
devastating
neurodegenerative
disorder.
Despite
clinical
and
experimental
evidence
implicating
intestinal
microbiota
a
number
brain
disorders,
its
impact
on
not
known.
To
end
we
sequenced
bacterial
16S
rRNA
from
fecal
samples
Aβ
precursor
protein
(APP)
transgenic
mouse
model
found
remarkable
shift
gut
as
compared
to
non-transgenic
wild-type
mice.
Subsequently
generated
germ-free
APP
mice
drastic
reduction
cerebral
amyloid
pathology
when
control
with
microbiota.
Importantly,
colonization
conventionally-raised
increased
pathology,
while
was
less
effective
increasing
levels.
Our
results
indicate
microbial
involvement
development
Abeta
suggest
that
may
contribute
diseases.
