Science,
Год журнала:
2018,
Номер
360(6390), С. 795 - 800
Опубликована: Май 3, 2018
The
immune
system
responds
vigorously
to
microbial
infection
while
permitting
lifelong
colonization
by
the
microbiome.
Mechanisms
that
facilitate
establishment
and
stability
of
gut
microbiota
remain
poorly
described.
We
found
a
regulatory
in
prominent
human
commensal
Bacteroides
fragilis
modulates
its
surface
architecture
invite
binding
immunoglobulin
A
(IgA)
mice.
Specific
recognition
facilitated
bacterial
adherence
cultured
intestinal
epithelial
cells
intimate
association
with
mucosal
vivo.
IgA
response
was
required
for
B.
(and
other
species)
occupy
defined
niche
mediates
stable
through
exclusion
exogenous
competitors.
Therefore,
addition
role
pathogen
clearance,
we
propose
responses
can
be
co-opted
microbiome
engender
robust
host-microbial
symbiosis.
Cell Research,
Год журнала:
2020,
Номер
30(6), С. 492 - 506
Опубликована: Май 20, 2020
Abstract
The
interplay
between
the
commensal
microbiota
and
mammalian
immune
system
development
function
includes
multifold
interactions
in
homeostasis
disease.
microbiome
plays
critical
roles
training
of
major
components
host’s
innate
adaptive
system,
while
orchestrates
maintenance
key
features
host-microbe
symbiosis.
In
a
genetically
susceptible
host,
imbalances
microbiota-immunity
under
defined
environmental
contexts
are
believed
to
contribute
pathogenesis
multitude
immune-mediated
disorders.
Here,
we
review
microbiome-immunity
crosstalk
their
health
disease,
providing
examples
molecular
mechanisms
orchestrating
these
intestine
extra-intestinal
organs.
We
highlight
aspects
current
knowledge,
challenges
limitations
achieving
causal
understanding
host
immune-microbiome
interactions,
as
well
impact
on
diseases,
discuss
how
insights
may
translate
towards
future
microbiome-targeted
therapeutic
interventions.
Immunological Reviews,
Год журнала:
2017,
Номер
279(1), С. 70 - 89
Опубликована: Авг. 30, 2017
Summary
The
intestinal
tract
of
mammals
is
colonized
by
a
large
number
microorganisms
including
trillions
bacteria
that
are
referred
to
collectively
as
the
gut
microbiota.
These
indigenous
have
co‐evolved
with
host
in
symbiotic
relationship.
In
addition
metabolic
benefits,
provide
several
functions
promote
immune
homeostasis,
responses,
and
protection
against
pathogen
colonization.
ability
inhibit
colonization
mediated
via
mechanisms
direct
killing,
competition
for
limited
nutrients,
enhancement
responses.
Pathogens
evolved
strategies
their
replication
presence
Perturbation
microbiota
structure
environmental
genetic
factors
increases
risk
infection,
promotes
overgrowth
harmful
pathobionts,
development
inflammatory
disease.
Understanding
interaction
pathogens
system
will
critical
insight
into
pathogenesis
disease
prevent
treat
Immunology,
Год журнала:
2017,
Номер
151(4), С. 363 - 374
Опубликована: Май 23, 2017
The
microbiota
plays
a
central
role
in
human
health
and
disease
by
shaping
immune
development,
responses
metabolism,
protecting
from
invading
pathogens.
Technical
advances
that
allow
comprehensive
characterization
of
microbial
communities
genetic
sequencing
have
sparked
the
hunt
for
disease-modulating
bacteria.
Emerging
studies
humans
linked
increased
abundance
Prevotella
species
at
mucosal
sites
to
localized
systemic
disease,
including
periodontitis,
bacterial
vaginosis,
rheumatoid
arthritis,
metabolic
disorders
low-grade
inflammation.
Intriguingly,
is
reduced
within
lung
patients
with
asthma
chronic
obstructive
pulmonary
disease.
Increased
associated
augmented
T
helper
type
17
(Th17)
-mediated
inflammation,
which
line
marked
capacity
driving
Th17
vitro.
Studies
indicate
predominantly
activate
Toll-like
receptor
2,
leading
production
Th17-polarizing
cytokines
antigen-presenting
cells,
interleukin-23
(IL-23)
IL-1.
Furthermore,
stimulate
epithelial
cells
produce
IL-8,
IL-6
CCL20,
can
promote
neutrophil
recruitment.
Prevotella-mediated
inflammation
leads
dissemination
inflammatory
mediators,
bacteria
products,
turn
may
affect
outcomes.
mice
support
causal
as
colonization
experiments
clinical
features
When
compared
strict
commensal
bacteria,
exhibit
properties,
demonstrated
release
mediators
various
stromal
cells.
These
findings
some
strains
be
clinically
important
pathobionts
participate
promoting
