Nature Aging, Год журнала: 2021, Номер 1(1), С. 29 - 35
Опубликована: Янв. 14, 2021
Язык: Английский
Cell, Год журнала: 2023, Номер 186(2), С. 243 - 278
Опубликована: Янв. 1, 2023
Язык: Английский
Процитировано
2784
Aging Cell, Год журнала: 2019, Номер 18(6)
Опубликована: Сен. 27, 2019
Abstract An emerging body of data suggests that lipid metabolism has an important role to play in the aging process. Indeed, a plethora dietary, pharmacological, genetic, and surgical lipid‐related interventions extend lifespan nematodes, fruit flies, mice, rats. For example, impairment genes involved ceramide sphingolipid synthesis extends both worms flies. The overexpression fatty acid amide hydrolase or lysosomal lipase prolongs life Caenorhabditis elegans , while diacylglycerol enhances longevity C. Drosophila melanogaster . removal adipose tissue rats, increased expression apolipoprotein D survival flies mice. Mouse can be additionally extended by genetic deletion acyltransferase 1, treatment with steroid 17‐α‐estradiol, ketogenic diet. Moreover, phospholipase A2 receptor improves various healthspan parameters progeria mouse model. Genome‐wide association studies have found several variants associated human aging. epsilon 2 4 alleles E are extreme late‐onset neurodegenerative disease, respectively. In humans, blood triglyceride levels tend increase, lysophosphatidylcholine decrease age. Specific phospholipid profiles also been shown change age exceptional longevity. These suggest may improve lipids likely represent rich source biomarkers.
Язык: Английский
Процитировано
342
Nature Reviews Genetics, Год журнала: 2022, Номер 23(12), С. 715 - 727
Опубликована: Июнь 17, 2022
Язык: Английский
Процитировано
301
Cell Metabolism, Год журнала: 2023, Номер 35(1), С. 12 - 35
Опубликована: Янв. 1, 2023
Язык: Английский
Процитировано
271
Nature Reviews Drug Discovery, Год журнала: 2020, Номер 20(1), С. 21 - 38
Опубликована: Ноя. 10, 2020
Язык: Английский
Процитировано
247
Science China Life Sciences, Год журнала: 2022, Номер 65(12), С. 2354 - 2454
Опубликована: Сен. 2, 2022
Язык: Английский
Процитировано
240
Nature Communications, Год журнала: 2021, Номер 12(1)
Опубликована: Май 17, 2021
Dietary restriction (DR) decreases body weight, improves health, and extends lifespan. DR can be achieved by controlling how much and/or when food is provided, as well adjusting nutritional composition. Because these factors are often combined during DR, it unclear which necessary for beneficial effects. Several drugs have been utilized that target nutrient-sensing gene pathways, many of change expression throughout the day, suggesting timing drug administration critical. Here, we discuss dietary pharmacological interventions promote a healthy lifespan influencing energy intake circadian rhythms.
Язык: Английский
Процитировано
183
Trends in Biochemical Sciences, Год журнала: 2020, Номер 45(7), С. 578 - 592
Опубликована: Апрель 6, 2020
Язык: Английский
Процитировано
153
Science Translational Medicine, Год журнала: 2021, Номер 13(575)
Опубликована: Янв. 6, 2021
Inactivation of the histone acetyltransferase gene KAT7 prolongs survival in naturally aged mice and progeroid that age prematurely.
Язык: Английский
Процитировано
114
Antioxidants, Год журнала: 2022, Номер 11(7), С. 1224 - 1224
Опубликована: Июнь 22, 2022
Cellular senescence is an irreversible state of cell cycle arrest occurring in response to stressful stimuli, such as telomere attrition, DNA damage, reactive oxygen species, and oncogenic proteins. Although beneficial protective several physiological processes, excessive senescent burden has been involved various pathological conditions including aging, tissue dysfunction chronic diseases. Oxidative stress (OS) can drive due a loss balance between pro-oxidant stimuli antioxidant defences. Therefore, the identification characterization compounds capable preventing or counteracting phenotype major interest. However, despite considerable number studies, comprehensive overview main molecules OS-induced still lacking. Here, besides brief description molecular mechanisms implicated OS-mediated we review discuss role enzymes, mitochondria-targeting compounds, vitamins, carotenoids, organosulfur nitrogen non-protein molecules, minerals, flavonoids, non-flavonoids with anti-aging potential, therefore offering insights into innovative lifespan-extending approaches.
Язык: Английский
Процитировано
90