DNA sensing via the cGAS/STING pathway activates the immunoproteasome and adaptive T‐cell immunity DOI Creative Commons
Xinyuan Wang, Huabin Zhang, Yuqin Wang

и другие.

The EMBO Journal, Год журнала: 2023, Номер 42(8)

Опубликована: Март 13, 2023

Abstract The immunoproteasome is a specialized type of proteasome involved in MHC class I antigen presentation, antiviral adaptive immunity, autoimmunity, and also part broader response to stress. Whether the regulated by DNA stress, however, not known. We here demonstrate that mitochondrial stress upregulates presentation pathway via cGAS/STING/type interferon signaling resulting cell autonomous activation CD8 + T cells. cGAS/STING‐induced immune observed genomic conserved epithelial mesenchymal cells mice men. In patients with idiopathic pulmonary fibrosis, chronic aberrant lung concurs T‐cell diseased lungs. Genetic depletion specific inhibitors counteract induced cytotoxic activation. Our data thus unravel cytoplasmic sensing cGAS/STING as an activator This represents novel potential pathomechanism for fibrosis opens new therapeutic perspectives.

Язык: Английский

Chromatin basis of the senescence-associated secretory phenotype DOI Creative Commons
Hao Xue, Chen Wang, Rugang Zhang

и другие.

Trends in Cell Biology, Год журнала: 2022, Номер 32(6), С. 513 - 526

Опубликована: Янв. 7, 2022

Язык: Английский

Процитировано

64
The Immunological Conundrum of Endogenous Retroelements DOI Creative Commons
George Kassiotis

Annual Review of Immunology, Год журнала: 2023, Номер 41(1), С. 99 - 125

Опубликована: Янв. 11, 2023

Our defenses against infection rely on the ability of immune system to distinguish invading pathogens from self. This task is exceptionally challenging, if not seemingly impossible, in case retroviruses that have integrated almost seamlessly into host. review examines limits innate and adaptive responses elicited by endogenous other retroelements, targets recognition, consequences for host health disease. Contrary theoretical expectation, retroelements retain substantial immunogenicity, which manifests most profoundly when their epigenetic repression compromised, contributing autoinflammatory autoimmune disease age-related inflammation. Nevertheless, recent evidence suggests regulated reactivity integral development function, underpinning cancer immunosurveillance, resistance infection, microbiota. Elucidation interaction points with will therefore deepen our understanding function contribution

Язык: Английский

Процитировано

37
Polyamine metabolism controls B-to-Z DNA transition to orchestrate DNA sensor cGAS activity DOI Creative Commons
Chunyuan Zhao,

Yunjin Ma,

Minghui Zhang

и другие.

Immunity, Год журнала: 2023, Номер 56(11), С. 2508 - 2522.e6

Опубликована: Окт. 16, 2023

Язык: Английский

Процитировано

30
Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca2+ release to protect stressed replication forks DOI Creative Commons
Shan Li,

Lingzhen Kong,

Ying Shirley Meng

и другие.

Molecular Cell, Год журнала: 2023, Номер 83(4), С. 556 - 573.e7

Опубликована: Янв. 24, 2023

Язык: Английский

Процитировано

27
DNA sensing via the cGAS/STING pathway activates the immunoproteasome and adaptive T‐cell immunity DOI Creative Commons
Xinyuan Wang, Huabin Zhang, Yuqin Wang

и другие.

The EMBO Journal, Год журнала: 2023, Номер 42(8)

Опубликована: Март 13, 2023

Abstract The immunoproteasome is a specialized type of proteasome involved in MHC class I antigen presentation, antiviral adaptive immunity, autoimmunity, and also part broader response to stress. Whether the regulated by DNA stress, however, not known. We here demonstrate that mitochondrial stress upregulates presentation pathway via cGAS/STING/type interferon signaling resulting cell autonomous activation CD8 + T cells. cGAS/STING‐induced immune observed genomic conserved epithelial mesenchymal cells mice men. In patients with idiopathic pulmonary fibrosis, chronic aberrant lung concurs T‐cell diseased lungs. Genetic depletion specific inhibitors counteract induced cytotoxic activation. Our data thus unravel cytoplasmic sensing cGAS/STING as an activator This represents novel potential pathomechanism for fibrosis opens new therapeutic perspectives.

Язык: Английский

Процитировано

25