Mitohormesis

Cell Metabolism, Год журнала: 2023, Номер 35(11), С. 1872 - 1886

Опубликована: Ноя. 1, 2023

Язык: Английский

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Cell survival following direct executioner-caspase activation

Proceedings of the National Academy of Sciences, Год журнала: 2023, Номер 120(4)

Опубликована: Янв. 20, 2023

Executioner-caspase activation has been considered a point-of-no-return in apoptosis. However, numerous studies report survival from caspase after treatment with drugs or radiation. An open question is whether cells can recover direct without pro-survival stress responses induced by drugs. To address this question, we engineered HeLa cell line to express caspase-3 inducibly and combined it quantitative activity reporter. While high levels killed all very low allowed live, doses of sufficient kill 15 30% nevertheless 70 85% survive. At these doses, neither the rate, nor peak level, total amount could accurately predict death versus survival. Thus, survive executioner-caspase activation, variations cellular state modify outcome potentially lethal activity. Such heterogeneities may underlie incomplete tumor killing response apoptosis-inducing cancer treatments.

Язык: Английский

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Metabolic sensing and control in mitochondria

Molecular Cell, Год журнала: 2023, Номер 83(6), С. 877 - 889

Опубликована: Март 1, 2023

Язык: Английский

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Non-lethal outcomes of engaging regulated cell death pathways in cancer

Nature Cancer, Год журнала: 2023, Номер 4(6), С. 795 - 806

Опубликована: Июнь 5, 2023

Язык: Английский

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BRD4 inhibition sensitizes diffuse large B-cell lymphoma cells to ferroptosis

Blood, Год журнала: 2023, Номер 142(13), С. 1143 - 1155

Опубликована: Июнь 9, 2023

Язык: Английский

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