Cell Reports, Год журнала: 2025, Номер 44(4), С. 115441 - 115441
Опубликована: Март 18, 2025
Язык: Английский
Cell Metabolism, Год журнала: 2023, Номер 35(8), С. 1283 - 1303
Опубликована: Авг. 1, 2023
Язык: Английский
Процитировано
91
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Окт. 18, 2024
Immunotherapy has made significant strides in cancer treatment, particularly through immune checkpoint blockade (ICB), which shown notable clinical benefits across various tumor types. Despite the transformative impact of ICB treatment therapy, only a minority patients exhibit positive response to it. In with solid tumors, those who respond well typically demonstrate an active profile referred as "hot" (immune-inflamed) phenotype. On other hand, non-responsive may distinct "cold" (immune-desert) phenotype, differing from features tumors. Additionally, there is more nuanced "excluded" positioned between and categories, known type. Effective differentiation understanding intrinsic factors, characteristics, TME, external factors are critical for predicting results. It widely accepted that therapy exerts profound effect on limited efficacy against or "altered" necessitating combinations therapeutic modalities enhance cell infiltration into tissue convert tumors ones. Therefore, aligning traits this review systematically delineates respective influencing extensively discusses varied approaches drug targets based assess efficacy.
Язык: Английский
Процитировано
35
Cell stem cell, Год журнала: 2024, Номер 31(2), С. 161 - 180
Опубликована: Фев. 1, 2024
Язык: Английский
Процитировано
34
Journal of Clinical Investigation, Год журнала: 2024, Номер 134(3)
Опубликована: Фев. 1, 2024
Язык: Английский
Процитировано
21
Experimental & Molecular Medicine, Год журнала: 2024, Номер 56(5), С. 1066 - 1079
Опубликована: Май 1, 2024
The glycerol 3-phosphate shuttle (GPS) is composed of two different enzymes: cytosolic NAD
Язык: Английский
Процитировано
16
Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)
Опубликована: Фев. 11, 2025
Abstract Accumulated evidence has implicated the diverse and substantial influence of lactate on cellular differentiation fate regulation in physiological pathological settings, particularly intricate conditions such as cancer. Specifically, been demonstrated to be pivotal molding tumor microenvironment (TME) through its effects different cell populations. Within cells, impacts signaling pathways, augments shuttle process, boosts resistance oxidative stress, contributes lactylation. In various populations, interplay between immune cells governs processes differentiation, response, surveillance, treatment effectiveness. Furthermore, communication stromal/endothelial supports basal membrane (BM) remodeling, epithelial-mesenchymal transitions (EMT), metabolic reprogramming, angiogenesis, drug resistance. Focusing production transport, specifically dehydrogenase (LDH) monocarboxylate transporters (MCT), shown promise Inhibitors targeting LDH MCT act both suppressors enhancers immunotherapy, leading a synergistic therapeutic effect when combined with immunotherapy. The review underscores importance progression provides valuable perspectives potential approaches that target vulnerability metabolism, highlighting Heel Achilles for cancer treatment.
Язык: Английский
Процитировано
8
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(21), С. 15787 - 15787
Опубликована: Окт. 31, 2023
The Warburg effect is the long-standing riddle of cancer biology. How does aerobic glycolysis, inefficient in producing ATP, confer a growth advantage to cells? A new evaluation large set literature findings covering and its yeast counterpart, Crabtree effect, led an innovative working hypothesis presented here. It holds that enhanced glycolysis partially inactivates oxidative phosphorylation induce functional rewiring TCA cycle enzymes generate non-canonical metabolic pathways sustain faster rates. has been structured by constructing two maps, one for metabolism other effect. New lines investigation, suggested these are discussed as instrumental leading toward better understanding biology order allow development more efficient metabolism-targeted anticancer drugs.
Язык: Английский
Процитировано
33
Cell Death and Disease, Год журнала: 2023, Номер 14(11)
Опубликована: Ноя. 11, 2023
Abstract Cervical cancer (CC) is a gynecological neoplasm with the highest incidence rate, primarily attributed to persistent infection of high-risk Human papillomavirus (HPV). Despite extensive research, pathogenesis CC remains unclear. N6-methyladenosine (m6A) methylation, most prevalent form epigenetic modification in RNA, intricately linked cell proliferation, metastasis, metabolism, and therapeutic resistance within tumor microenvironment (TME) CC. The involvement writer, reader, eraser m6A impacts advancement tumors through regulation RNA stability, nuclear export, translation efficiency, degradation. Here, we discuss biogenesis m6A, atypical expressions regulators, mechanisms molecular interactions, their functions Furthermore, elucidate non-coding RNA. In context precision medicine, advancements genomics, proteomics, high-throughput sequencing technologies, summarize application clinical diagnosis treatment Additionally, new perspectives on detection methods, immune regulation, nano-drug development are presented, which lay foundation for further research provide ideas
Язык: Английский
Процитировано
22
Science Bulletin, Год журнала: 2024, Номер 69(9), С. 1263 - 1274
Опубликована: Фев. 9, 2024
Язык: Английский
Процитировано
14
Experimental Hematology and Oncology, Год журнала: 2024, Номер 13(1)
Опубликована: Май 22, 2024
Abstract Radiotherapy is one of the mainstream approaches for cancer treatment, although clinical outcomes are limited due to radioresistance tumor cells. Hypoxia and metabolic reprogramming hallmarks initiation progression closely linked radioresistance. Inside a tumor, rate angiogenesis lags behind cell proliferation, underdevelopment abnormal functions blood vessels in some loci result oxygen deficiency cells, i.e., hypoxia. This prevents radiation from effectively eliminating hypoxic Cancer cells switch glycolysis as main source energy, phenomenon known Warburg effect, sustain their rapid proliferation rates. Therefore, pathways involved hypoxia-induced promising intervention targets treatment. In this review, we discussed mechanisms underlying hypoxia detail, including DNA repair, role stem oxidative stress relief, autophagy regulation, immune escape. addition, proposed existence feedback loop between energy hypoxia, which associated with development exacerbation tumors. Simultaneous blockade other tumor-specific can be an effective approach overcome comprehensive overview provides new insights into radiosensitivity progression.
Язык: Английский
Процитировано
12