Molecular Biology of the Cell,
Год журнала:
2025,
Номер
36(2)
Опубликована: Янв. 28, 2025
The
cellular
electrical
signals
of
living
organisms
were
discovered
more
than
a
century
ago
and
have
been
extensively
investigated
in
the
neuromuscular
system.
Neuronal
depolarization
hyperpolarization
are
essential
for
our
physiological
pathological
functions.
Bioelectricity
is
being
recognized
as
an
ancient,
intrinsic,
fundamental
property
all
cells,
it
not
limited
to
Instead,
emerging
evidence
supports
view
bioelectricity
instructional
signaling
cue
physiology,
embryonic
development,
regeneration,
human
diseases,
including
cancers.
Here,
we
highlight
current
understanding
share
views
on
challenges
perspectives.
Cancer Cell,
Год журнала:
2024,
Номер
42(9), С. 1528 - 1548.e17
Опубликована: Сен. 1, 2024
Diffuse
hemispheric
gliomas,
H3G34R/V-mutant
(DHG-H3G34),
are
lethal
brain
tumors
lacking
targeted
therapies.
They
originate
from
interneuronal
precursors;
however,
leveraging
this
origin
for
therapeutic
insights
remains
unexplored.
Here,
we
delineate
a
cellular
hierarchy
along
the
interneuron
lineage
development
continuum,
revealing
that
DHG-H3G34
mirror
spatial
patterns
of
progenitor
streams
surrounding
nests,
as
seen
during
human
development.
Integrating
these
findings
with
genome-wide
CRISPR-Cas9
screens
identifies
genes
upregulated
in
progenitors
major
dependencies.
Among
these,
CDK6
emerges
targetable
vulnerability:
tumor
cells
show
enhanced
sensitivity
to
CDK4/6
inhibitors
and
CDK6-specific
degrader,
promoting
shift
toward
more
mature
interneuron-like
states,
reducing
growth,
prolonging
xenograft
survival.
Notably,
patient
progressive
treated
inhibitor
achieved
17
months
stable
disease.
This
study
underscores
progenitor-like
organized
characteristic
niches,
distinct
vulnerability
DHG-H3G34,
highlighting
promising
clinically
actionable
target.
Glioblastomas
are
invasive
brain
tumors
with
high
therapeutic
resistance.
Neuron-to-glioma
synapses
have
been
shown
to
promote
glioblastoma
progression.
However,
a
characterization
of
tumor-connected
neurons
has
hampered
by
lack
technologies.
Here,
we
adapted
retrograde
tracing
using
rabies
viruses
investigate
and
manipulate
neuron-tumor
networks.
Glioblastoma
rapidly
integrated
into
neural
circuits
across
the
brain,
engaging
in
widespread
functional
communication,
cholinergic
driving
invasion.
We
uncovered
patient-specific
tumor-cell-state-dependent
differences
synaptogenic
gene
expression
associated
connectivity
subsequent
invasiveness.
Importantly,
radiotherapy
enhanced
increased
neuronal
activity.
In
turn,
simultaneous
activity
inhibition
showed
effects,
indicative
role
for
neuron-to-glioma
contributing
Lastly,
rabies-mediated
genetic
ablation
halted
progression,
offering
viral
strategy
tackle
glioblastoma.
Together,
this
study
provides
framework
comprehensively
characterize
networks
target
Coordination Chemistry Reviews,
Год журнала:
2024,
Номер
519, С. 216109 - 216109
Опубликована: Авг. 1, 2024
Immunotherapy
is
a
promising
strategy
to
inhibit
the
progression
of
solid
tumors.
However,
current
vaccine
adjuvants
represented
by
aluminum
adjuvant
(Alum)
fail
tumor
antigens
initiate
effective
T
cell
immunity.
Despite
efforts
have
been
made
optimize
physical
characteristics
Alum,
lack
specific
immunostimulatory
functions
still
results
in
their
inability
effectively
induce
cytotoxic
immune
responses.
Encouragingly,
an
iterative
layered
double
hydroxide
(LDH)
nano‑aluminum
(NanoAlum)
re-engineered
from
clinical
AlOOH
Alum
and
Mg(OH)2
antacid
has
shown
efficacy
evoking
both
potent
humoral
cellular
Notably,
it
can
also
serve
as
microenvironmental
immunomodulator
reshape
aberrant
physicochemical
attributes
microenvironment.
Interestingly,
highly
flexible
crystal
structure
chemical
composition
offer
variety
LDH-based
candidates
(NanoMAlum)
doping
with
body
essential
nutritional
metal
ions
(M),
which
show
great
potential
amplify
immunotherapy.
In
this
review,
we
summarize
development
progress
LDH
NanoAlum
its
variants
NanoMAlum
for
cancer
By
rethinking
challenges
that
hindered
preclinical/clinical
application,
charted
research
pathway
based
on
engineered
organoids
accelerate
applications
these
NanoMAlums
review.
Molecular Biology of the Cell,
Год журнала:
2025,
Номер
36(2)
Опубликована: Янв. 28, 2025
The
cellular
electrical
signals
of
living
organisms
were
discovered
more
than
a
century
ago
and
have
been
extensively
investigated
in
the
neuromuscular
system.
Neuronal
depolarization
hyperpolarization
are
essential
for
our
physiological
pathological
functions.
Bioelectricity
is
being
recognized
as
an
ancient,
intrinsic,
fundamental
property
all
cells,
it
not
limited
to
Instead,
emerging
evidence
supports
view
bioelectricity
instructional
signaling
cue
physiology,
embryonic
development,
regeneration,
human
diseases,
including
cancers.
Here,
we
highlight
current
understanding
share
views
on
challenges
perspectives.
