Abstract
Ferroptosis
is
a
type
of
regulated
cell
death
characterized
by
iron
accumulation
and
uncontrolled
lipid
peroxidation,
leading
to
plasma
membrane
rupture
intracellular
content
release.
Originally
investigated
as
targeted
therapy
for
cancer
cells
carrying
oncogenic
RAS
mutations,
ferroptosis
induction
now
exhibits
potential
complement
chemotherapy,
immunotherapy,
radiotherapy
in
various
types.
However,
it
can
lead
side
effects,
including
immune
death,
bone
marrow
impairment,
liver
kidney
damage,
cachexia
(severe
weight
loss
muscle
wasting),
secondary
tumorigenesis.
In
this
review,
we
discuss
the
advantages
offer
an
overview
diverse
range
documented
effects.
Furthermore,
examine
underlying
mechanisms
explore
strategies
effect
mitigation.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Сен. 21, 2023
Abstract
Ferroptosis
is
an
iron-dependent
form
of
regulated
cell
death
with
distinct
characteristics,
including
altered
iron
homeostasis,
reduced
defense
against
oxidative
stress,
and
abnormal
lipid
peroxidation.
Recent
studies
have
provided
compelling
evidence
supporting
the
notion
that
ferroptosis
plays
a
key
pathogenic
role
in
many
diseases
such
as
various
cancer
types,
neurodegenerative
disease,
involving
tissue
and/or
organ
injury,
inflammatory
infectious
diseases.
Although
precise
regulatory
networks
underlie
are
largely
unknown,
particularly
respect
to
initiation
progression
diseases,
recognized
bona
fide
target
for
further
development
treatment
prevention
strategies.
Over
past
decade,
considerable
progress
has
been
made
developing
pharmacological
agonists
antagonists
these
ferroptosis-related
conditions.
Here,
we
provide
detailed
overview
our
current
knowledge
regarding
ferroptosis,
its
pathological
roles,
regulation
during
disease
progression.
Focusing
on
use
chemical
tools
preclinical
studies,
also
summarize
recent
advances
targeting
across
growing
spectrum
ferroptosis-associated
Finally,
discuss
new
challenges
opportunities
potential
strategy
treating
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Март 8, 2024
Ferroptosis
is
a
non-apoptotic
form
of
regulated
cell
death
characterized
by
the
lethal
accumulation
iron-dependent
membrane-localized
lipid
peroxides.
It
acts
as
an
innate
tumor
suppressor
mechanism
and
participates
in
biological
processes
tumors.
Intriguingly,
mesenchymal
dedifferentiated
cancer
cells,
which
are
usually
resistant
to
apoptosis
traditional
therapies,
exquisitely
vulnerable
ferroptosis,
further
underscoring
its
potential
treatment
approach
for
cancers,
especially
refractory
cancers.
However,
impact
ferroptosis
on
extends
beyond
direct
cytotoxic
effect
cells.
induction
not
only
inhibits
but
also
promotes
development
due
negative
anticancer
immunity.
Thus,
comprehensive
understanding
role
crucial
successful
translation
therapy
from
laboratory
clinical
applications.
In
this
review,
we
provide
overview
recent
advancements
cancer,
covering
molecular
mechanisms,
functions,
regulatory
pathways,
interactions
with
microenvironment.
We
summarize
applications
immunotherapy,
radiotherapy,
systemic
therapy,
well
inhibition
various
conditions.
finally
discuss
markers,
current
challenges
future
directions
cancer.
Cell Death and Disease,
Год журнала:
2023,
Номер
14(8)
Опубликована: Авг. 14, 2023
Abstract
Ferroptosis
is
a
form
of
regulated
cell
death
induced
by
iron-dependent
lipid
peroxidation,
and
it
has
been
studied
extensively
since
its
discovery
in
2012.
Induced
iron
overload
ROS
accumulation,
ferroptosis
modulated
various
cellular
metabolic
signaling
pathways.
The
GSH-GPX4
pathway,
the
FSP1-CoQ10
GCH1-BH4
DHODH-CoQH2
system
sex
hormones
suppress
ferroptosis.
Mitochondrial
metabolism
regulates
mitochondria
also
undergo
morphological
change
during
ferroptosis,
these
changes
include
increased
membrane
density
reduced
mitochondrial
cristae.
Moreover,
energy
oxidative
phosphorylation
ATP
production
rates
lead
to
decrease
glycolysis
rate.
In
addition,
excessive
stress
induces
irreversible
damage
mitochondria,
diminishing
organelle
integrity.
production,
potential,
fusion
fission,
mitophagy
function
Notably,
some
inhibitors
target
mitochondria.
major
mechanism
for
associated
with
progression
cancer.
Metastasis-prone
or
metastatic
cancer
cells
are
more
susceptible
Inducing
tumor
shows
very
promising
potential
treating
drug-resistant
cancers.
this
review,
we
present
brief
retrospect
characteristics
then
discuss
regulation
highlight
unique
role
played
cells.
Furthermore,
explain
how
functions
as
double-edged
sword
well
novel
therapies
aimed
at
selectively
manipulating
eradication.
