Spatial and single-nucleus transcriptomic profile of a chimpanzee frontal pole
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 17, 2025
Abstract
Chimpanzees,
our
closest
living
relatives,
share
a
vast
amount
of
genetic
code,
with
the
majority
differences
found
in
non-coding
regions
genome.
Functional
and
gene
regulatory
drive
phenotypic
divergence,
including
distinctive
brain
anatomy
humans
compared
to
chimpanzees
other
apes.
However,
little
is
known
about
species
expression,
how
they
relate
evolution
neuroanatomy
cognition.
This
primarily
due
limited
availability
great
ape
samples
challenges
comparative
spatial
transcriptomic
studies.
Here,
we
present
first
data
from
chimpanzee
based
on
post
mortem
tissue
an
adult
female,
who
was
euthanised
poor
health.
We
focus
frontal
pole,
region
that
has
undergone
significant
evolutionary
changes
size
organisation
since
last
common
ancestor
chimpanzees,
considered
critical
for
cognitive
evolution.
examined
expression
profiles
cell-type
composition
pole
left
hemisphere,
both
neuronal
non-neuronal
cell
types
across
cortical
layers
white
matter.
By
integrating
publicly
available
single-nucleus
dataset
dorsolateral
prefrontal
cortex,
mapped
distribution
29
types.
study
represents
step
towards
characterisation
between
brains
non-human
apes
humans.
Язык: Английский
Genomic basis of non-human-primate diversity and adaptation
Опубликована: Март 31, 2025
Язык: Английский
Deciphering the role of structural variation in human evolution: a functional perspective
Current Opinion in Genetics & Development,
Год журнала:
2024,
Номер
88, С. 102240 - 102240
Опубликована: Авг. 8, 2024
Advances
in
sequencing
technologies
have
enabled
the
comparison
of
high-quality
genomes
diverse
primate
species,
revealing
vast
amounts
divergence
due
to
structural
variation.
Given
their
large
size,
variants
(SVs)
can
simultaneously
alter
function
and
regulation
multiple
genes.
Studies
estimate
that
collectively
more
than
3.5%
genome
is
divergent
humans
versus
other
great
apes,
impacting
thousands
Functional
genomics
gene-editing
tools
various
model
systems
recently
emerged
as
an
exciting
frontier
-
investigating
wide-ranging
impacts
SVs
on
molecular,
cellular,
systems-level
phenotypes.
This
review
examines
existing
research
identifies
future
directions
broaden
our
understanding
functional
roles
phenotypic
innovations
diversity
uniquely
human
features,
ranging
from
cognition
metabolic
adaptations.
Язык: Английский
Advances in skeletal genomics research across tissues and cells
Current Opinion in Genetics & Development,
Год журнала:
2024,
Номер
88, С. 102245 - 102245
Опубликована: Авг. 24, 2024
Phenotypic
variation
within
the
skeleton
has
biological,
behavioral,
and
biomedical
functional
implications
for
individuals
species.
Thus,
it
is
critical
to
understand
how
genomic,
environmental,
mediating
regulatory
factors
combine
interact
drive
skeletal
trait
development
evolution.
Recent
research
efforts
clarify
these
mechanisms
have
been
made
possible
by
expanded
collections
of
genomic
phenotypic
data
from
in
vivo
tissues,
as
well
relevant
vitro
cell
culture
systems.
This
review
outlines
this
current
work
recommends
that
continued
exploration
complexity
should
include
an
increased
focus
on
interactions
between
physiologically
contexts
contribute
at
population
evolutionary
scales.
Язык: Английский