Uncertainty of adolescent brain maturation sex difference claims DOI Creative Commons

Cordelia Fine,

Lisa G. Cope,

L.J. Elliott

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(49)

Опубликована: Ноя. 25, 2024

Emotions coordinate our behavior and physiological states during survival-salient events pleasurable interactions. Even though we are often consciously aware of current emotional state, such as anger or happiness, the mechanisms giving ...Emotions felt in body, somatosensory feedback has been proposed to trigger conscious experiences. Here reveal maps bodily sensations associated with different emotions using a unique topographical self-report method. In ...

Язык: Английский

Sexual Dimorphism in Migraine. Focus on Mitochondria DOI
Michał Fila, Łukasz Przysło, Marcin Derwich

и другие.

Current Pain and Headache Reports, Год журнала: 2025, Номер 29(1)

Опубликована: Янв. 6, 2025

Язык: Английский

Процитировано

2

The power—and complexity—of policy to drive advances in women’s health DOI Creative Commons
Bronwyn M. Graham, Cara Tannenbaum, Alice Witt

и другие.

Science Advances, Год журнала: 2025, Номер 11(10)

Опубликована: Март 5, 2025

As international investments in women's health increase, funders are adopting sex and gender policies regulators requiring disaggregated data, actions which impact research design.

Язык: Английский

Процитировано

1

Why Gender and Sex Matter in Infectious Disease Modelling: A Conceptual Framework DOI Creative Commons
Diane Auderset, Julien Riou, Carole Clair

и другие.

SSM - Population Health, Год журнала: 2025, Номер 30, С. 101775 - 101775

Опубликована: Март 12, 2025

The COVID-19 pandemic underscored the differential impact of infectious diseases across population groups, with gender and sex identified as important dimensions influencing transmission health outcomes. Sex-related biological factors, such differences in immune response comorbidities, contribute to men's heightened severity risks, while norms roles influence exposure patterns, adherence prevention measures, healthcare access, women's higher reported infection rates certain contexts. Despite widely observed gender/sex disparities, disease models frequently overlook key dimensions, leading gaps understanding potential blind spots public interventions. This paper develops a conceptual framework based on Susceptible-Exposed-Infectious-Recovered/Deceased (SEIR/D) compartmental model map pathways through which may susceptibility, exposure, transmission, recovery, mortality. Using narrative review modelling, epidemiological, clinical studies, this identifies characterises main social mechanisms matter-including gendered occupational preventive disparities healthcare-seeking behaviour-alongside sex-based severity. also examines gender-related variations epidemiological surveillance data, highlighting testing uptake hospitalisation referrals that could outputs. By synthesising these insights, provides theoretical foundation for integrating into models. It advocates interdisciplinary collaboration between modellers, scientists, clinicians advance gender- sex-sensitive modelling approaches. Accounting can enhance predictive accuracy, inform intervention strategies, promote equity response.

Язык: Английский

Процитировано

1

The Sex Inclusive Research Framework to address sex bias in preclinical research proposals DOI Creative Commons
Natasha A. Karp,

Manuel Berdoy,

Kelly Gray

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Апрель 22, 2025

An interactive Sex Inclusive Research Framework (SIRF) supports the evaluation of in vivo and ex research proposals to address risk sex bias preclinical research. The framework delivers a traffic light classification, indicating whether proposal is appropriate, risky, or insufficient with regard inclusion. This tool designed for use by researchers, (animal) ethical review boards, funders generate rigorous reproducible assessment inclusion at level, thus helping resolve embedded

Язык: Английский

Процитировано

1

Training in the implementation of sex and gender research policies: an evaluation of publicly available online courses DOI Creative Commons
Annika Gompers,

Madeline T. Olivier,

Donna L. Maney

и другие.

Biology of Sex Differences, Год журнала: 2024, Номер 15(1)

Опубликована: Апрель 3, 2024

Recently implemented research policies requiring the inclusion of females and males have created an urgent need for effective training in how to account sex, some cases gender, biomedical studies. Here, we evaluated three sets publicly available online materials on this topic: (1) Integrating Sex & Gender Health Research from Canadian Institutes (CIHR); (2) as a Biological Variable: A Primer United States National (NIH); (3) The Dimension Biomedical Research, developed part "Leading Innovative measures reach gender Balance Activities" (LIBRA) European Commission. We reviewed each course with respect their coverage What is required by policy; Rationale Handling concepts "sex" "gender;" (4) design analysis; (5) Interpreting reporting data. All courses discussed importance including better generalize results, discover potential sex differences, tailor treatments men women. entangled nature operationalization downsides focusing more than other sources variation were minimally discussed. Notably, all explicitly endorsed invalid analytical approaches that produce bias toward false positive discoveries difference. Our analysis suggests revised or new incorporate four major topics: precise risks over-emphasis category, recognition complex entangled, rigorous study data analysis.

Язык: Английский

Процитировано

5

We need more-nuanced approaches to exploring sex and gender in research DOI Creative Commons
Stacey A. Ritz, Lorraine Greaves

Nature, Год журнала: 2024, Номер 629(8010), С. 34 - 36

Опубликована: Май 1, 2024

Some scientists are reluctant to investigate questions about sex and gender, particularly given today's sociopolitical tensions around gender identity. But they should lean in embrace the complexity.

Язык: Английский

Процитировано

5

Enhancing brain health in the global south through a sex and gender lens DOI

Sandra Baez,

Laura Castro‐Aldrete,

Gabrielle B. Britton

и другие.

Nature Mental Health, Год журнала: 2024, Номер 2(11), С. 1308 - 1317

Опубликована: Окт. 28, 2024

Язык: Английский

Процитировано

5

Leveraging research into sex differences and steroid hormones to improve brain health DOI
Bonnie H. Lee,

Rand S. Eid,

Travis E. Hodges

и другие.

Nature Reviews Endocrinology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 25, 2024

Язык: Английский

Процитировано

5

Malicious Midwives, Fruitful Vines, and Bearded Women — Sex, Gender, and Medical Expertise in the Journal DOI Open Access

Ben Maldonado,

Jamie Marsella,

Abigail Higgins

и другие.

New England Journal of Medicine, Год журнала: 2024, Номер 390(21), С. 1941 - 1947

Опубликована: Июнь 1, 2024

Язык: Английский

Процитировано

4

A gender perspective on diet, microbiome, and sex hormone interplay in cardiovascular disease DOI Creative Commons
Nina Jovanović, Veronika Zach, Claudia Crocini

и другие.

Acta Physiologica, Год журнала: 2024, Номер unknown

Опубликована: Сен. 12, 2024

Abstract A unique interplay between body and environment embeds reflects host–microbiome interactions that contribute to sex‐differential disease susceptibility, symptomatology, treatment outcomes. These differences derive from individual biological factors, such as sex hormone action, sex‐divergent immune processes, X‐linked gene dosage effects, epigenetics, well their interaction across the lifespan. The gut microbiome is increasingly recognized a moderator of several systems are thus impacted by its function composition. In humans, components further interact with gender‐specific exposures dietary preferences, stressors, life experiences form complex whole, requiring innovative methodologies disentangle. Here, we summarize current knowledge among hormones, microbiota, system, vascular health relevance for epidemiology cardiovascular diseases. We outline clinical implications, identify gaps, place emphasis on required future studies address these gaps. addition, provide an overview caveats associated conducting research require consideration sex/gender differences. While previous work has inspected separately, here call attention translational utility combined perspective research, gender medicine, biology.

Язык: Английский

Процитировано

3