Proceedings of the National Academy of Sciences,
Год журнала:
2024,
Номер
121(49)
Опубликована: Ноя. 25, 2024
Emotions
coordinate
our
behavior
and
physiological
states
during
survival-salient
events
pleasurable
interactions.
Even
though
we
are
often
consciously
aware
of
current
emotional
state,
such
as
anger
or
happiness,
the
mechanisms
giving
...Emotions
felt
in
body,
somatosensory
feedback
has
been
proposed
to
trigger
conscious
experiences.
Here
reveal
maps
bodily
sensations
associated
with
different
emotions
using
a
unique
topographical
self-report
method.
In
...
As
international
investments
in
women's
health
increase,
funders
are
adopting
sex
and
gender
policies
regulators
requiring
disaggregated
data,
actions
which
impact
research
design.
SSM - Population Health,
Год журнала:
2025,
Номер
30, С. 101775 - 101775
Опубликована: Март 12, 2025
The
COVID-19
pandemic
underscored
the
differential
impact
of
infectious
diseases
across
population
groups,
with
gender
and
sex
identified
as
important
dimensions
influencing
transmission
health
outcomes.
Sex-related
biological
factors,
such
differences
in
immune
response
comorbidities,
contribute
to
men's
heightened
severity
risks,
while
norms
roles
influence
exposure
patterns,
adherence
prevention
measures,
healthcare
access,
women's
higher
reported
infection
rates
certain
contexts.
Despite
widely
observed
gender/sex
disparities,
disease
models
frequently
overlook
key
dimensions,
leading
gaps
understanding
potential
blind
spots
public
interventions.
This
paper
develops
a
conceptual
framework
based
on
Susceptible-Exposed-Infectious-Recovered/Deceased
(SEIR/D)
compartmental
model
map
pathways
through
which
may
susceptibility,
exposure,
transmission,
recovery,
mortality.
Using
narrative
review
modelling,
epidemiological,
clinical
studies,
this
identifies
characterises
main
social
mechanisms
matter-including
gendered
occupational
preventive
disparities
healthcare-seeking
behaviour-alongside
sex-based
severity.
also
examines
gender-related
variations
epidemiological
surveillance
data,
highlighting
testing
uptake
hospitalisation
referrals
that
could
outputs.
By
synthesising
these
insights,
provides
theoretical
foundation
for
integrating
into
models.
It
advocates
interdisciplinary
collaboration
between
modellers,
scientists,
clinicians
advance
gender-
sex-sensitive
modelling
approaches.
Accounting
can
enhance
predictive
accuracy,
inform
intervention
strategies,
promote
equity
response.
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Апрель 22, 2025
An
interactive
Sex
Inclusive
Research
Framework
(SIRF)
supports
the
evaluation
of
in
vivo
and
ex
research
proposals
to
address
risk
sex
bias
preclinical
research.
The
framework
delivers
a
traffic
light
classification,
indicating
whether
proposal
is
appropriate,
risky,
or
insufficient
with
regard
inclusion.
This
tool
designed
for
use
by
researchers,
(animal)
ethical
review
boards,
funders
generate
rigorous
reproducible
assessment
inclusion
at
level,
thus
helping
resolve
embedded
Biology of Sex Differences,
Год журнала:
2024,
Номер
15(1)
Опубликована: Апрель 3, 2024
Recently
implemented
research
policies
requiring
the
inclusion
of
females
and
males
have
created
an
urgent
need
for
effective
training
in
how
to
account
sex,
some
cases
gender,
biomedical
studies.
Here,
we
evaluated
three
sets
publicly
available
online
materials
on
this
topic:
(1)
Integrating
Sex
&
Gender
Health
Research
from
Canadian
Institutes
(CIHR);
(2)
as
a
Biological
Variable:
A
Primer
United
States
National
(NIH);
(3)
The
Dimension
Biomedical
Research,
developed
part
"Leading
Innovative
measures
reach
gender
Balance
Activities"
(LIBRA)
European
Commission.
We
reviewed
each
course
with
respect
their
coverage
What
is
required
by
policy;
Rationale
Handling
concepts
"sex"
"gender;"
(4)
design
analysis;
(5)
Interpreting
reporting
data.
All
courses
discussed
importance
including
better
generalize
results,
discover
potential
sex
differences,
tailor
treatments
men
women.
entangled
nature
operationalization
downsides
focusing
more
than
other
sources
variation
were
minimally
discussed.
Notably,
all
explicitly
endorsed
invalid
analytical
approaches
that
produce
bias
toward
false
positive
discoveries
difference.
Our
analysis
suggests
revised
or
new
incorporate
four
major
topics:
precise
risks
over-emphasis
category,
recognition
complex
entangled,
rigorous
study
data
analysis.
Nature,
Год журнала:
2024,
Номер
629(8010), С. 34 - 36
Опубликована: Май 1, 2024
Some
scientists
are
reluctant
to
investigate
questions
about
sex
and
gender,
particularly
given
today's
sociopolitical
tensions
around
gender
identity.
But
they
should
lean
in
embrace
the
complexity.
Acta Physiologica,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 12, 2024
Abstract
A
unique
interplay
between
body
and
environment
embeds
reflects
host–microbiome
interactions
that
contribute
to
sex‐differential
disease
susceptibility,
symptomatology,
treatment
outcomes.
These
differences
derive
from
individual
biological
factors,
such
as
sex
hormone
action,
sex‐divergent
immune
processes,
X‐linked
gene
dosage
effects,
epigenetics,
well
their
interaction
across
the
lifespan.
The
gut
microbiome
is
increasingly
recognized
a
moderator
of
several
systems
are
thus
impacted
by
its
function
composition.
In
humans,
components
further
interact
with
gender‐specific
exposures
dietary
preferences,
stressors,
life
experiences
form
complex
whole,
requiring
innovative
methodologies
disentangle.
Here,
we
summarize
current
knowledge
among
hormones,
microbiota,
system,
vascular
health
relevance
for
epidemiology
cardiovascular
diseases.
We
outline
clinical
implications,
identify
gaps,
place
emphasis
on
required
future
studies
address
these
gaps.
addition,
provide
an
overview
caveats
associated
conducting
research
require
consideration
sex/gender
differences.
While
previous
work
has
inspected
separately,
here
call
attention
translational
utility
combined
perspective
research,
gender
medicine,
biology.
