Annals of Oncology, Год журнала: 2024, Номер unknown
Опубликована: Сен. 1, 2024
Язык: Английский
Nature reviews. Cancer, Год журнала: 2024, Номер 24(8), С. 554 - 577
Опубликована: Июль 5, 2024
Язык: Английский
Процитировано
49
Molecular Cancer, Год журнала: 2024, Номер 23(1)
Опубликована: Май 18, 2024
Abstract Aging and cancer exhibit apparent links that we will examine in this review. The null hypothesis aging coincide because both are driven by time, irrespective of the precise causes, can be confronted with idea share common mechanistic grounds referred to as ‘hallmarks’. Indeed, several hallmarks also contribute carcinogenesis tumor progression, but some molecular cellular characteristics may reduce probability developing lethal cancer, perhaps explaining why very old age (> 90 years) is accompanied a reduced incidence neoplastic diseases. We discuss possibility process itself causes meaning time-dependent degradation supracellular functions accompanies produces byproduct or ‘age-associated disease’. Conversely, its treatment erode health drive process, has dramatically been documented for survivors diagnosed during childhood, adolescence, young adulthood. conclude connected superior including endogenous lifestyle factors, well bidirectional crosstalk, together render not only risk factor an important parameter must considered therapeutic decisions.
Язык: Английский
Процитировано
43
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Окт. 18, 2024
Immunotherapy has made significant strides in cancer treatment, particularly through immune checkpoint blockade (ICB), which shown notable clinical benefits across various tumor types. Despite the transformative impact of ICB treatment therapy, only a minority patients exhibit positive response to it. In with solid tumors, those who respond well typically demonstrate an active profile referred as "hot" (immune-inflamed) phenotype. On other hand, non-responsive may distinct "cold" (immune-desert) phenotype, differing from features tumors. Additionally, there is more nuanced "excluded" positioned between and categories, known type. Effective differentiation understanding intrinsic factors, characteristics, TME, external factors are critical for predicting results. It widely accepted that therapy exerts profound effect on limited efficacy against or "altered" necessitating combinations therapeutic modalities enhance cell infiltration into tissue convert tumors ones. Therefore, aligning traits this review systematically delineates respective influencing extensively discusses varied approaches drug targets based assess efficacy.
Язык: Английский
Процитировано
35
Nature reviews. Cancer, Год журнала: 2024, Номер 24(8), С. 578 - 589
Опубликована: Июнь 19, 2024
Язык: Английский
Процитировано
27
Journal of Medicinal Chemistry, Год журнала: 2024, Номер 67(14), С. 11488 - 11521
Опубликована: Июль 2, 2024
In recent years, synthetic lethality has been recognized as a solid paradigm for anticancer therapies. The discovery of growing number lethal targets led to significant expansion in the use lethality, far beyond poly(ADP-ribose) polymerase inhibitors used treat BRCA1/2-defective tumors. particular, molecular within DNA damage response have provided source that rapidly reached clinical trials. This Perspective focuses on most progress and their inhibitors, response, describing design associated therapeutic strategies. We will conclude by discussing current challenges new opportunities this promising field research, stimulate discussion medicinal chemistry community, allowing investigation reach its full potential.
Язык: Английский
Процитировано
16
Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)
Опубликована: Фев. 18, 2025
Abstract Breast cancer, characterized by unique epidemiological patterns and significant heterogeneity, remains one of the leading causes malignancy-related deaths in women. The increasingly nuanced molecular subtypes breast cancer have enhanced comprehension precision treatment this disease. mechanisms tumorigenesis progression been central to scientific research, with investigations spanning various perspectives such as tumor stemness, intra-tumoral microbiota, circadian rhythms. Technological advancements, particularly those integrated artificial intelligence, significantly improved accuracy detection diagnosis. emergence novel therapeutic concepts drugs represents a paradigm shift towards personalized medicine. Evidence suggests that optimal diagnosis models tailored individual patient risk expected are crucial, supporting era oncology for cancer. Despite rapid advancements increasing emphasis on clinical comprehensive update summary panoramic knowledge related disease needed. In review, we provide thorough overview global status including its epidemiology, factors, pathophysiology, subtyping. Additionally, elaborate latest research into contributing progression, emerging strategies, long-term management. This review offers valuable insights Cancer Research, thereby facilitating future progress both basic application.
Язык: Английский
Процитировано
6
Cell Reports, Год журнала: 2025, Номер 44(1), С. 115206 - 115206
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
3
Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)
Опубликована: Фев. 16, 2025
Язык: Английский
Процитировано
3
Taiwanese Journal of Obstetrics and Gynecology, Год журнала: 2024, Номер 63(5), С. 651 - 664
Опубликована: Сен. 1, 2024
The current review described a 55-year woman using 28 months to finish her surgery-based radiation-free multimodality treatment journey fight International Federation of Gynaecology & Obstetrics (FIGO) 2018 clinical stage IIA2 (cT2aN0M0) squamous cell carcinoma (SCC) the cervix. She received six cycles perioperative adjuvant therapy, including three neoadjuvant therapy (NAT) and postoperative by combination dose-dense chemotherapy (CT, weekly paclitaxel 80 mg/m
Язык: Английский
Процитировано
14
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Сен. 23, 2024
Язык: Английский
Процитировано
12