Trends in Immunology, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Nature, Год журнала: 2025, Номер 638(8050), С. 333 - 342
Опубликована: Фев. 12, 2025
Язык: Английский
Процитировано
3
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Янв. 24, 2025
Brain macrophages encompass two major populations: microglia in the parenchyma and border-associated (BAMs) extra-parenchymal compartments. These cells play crucial roles maintaining brain homeostasis immune surveillance. Microglia BAMs are phenotypically epigenetically distinct exhibit highly specialized functions tailored to their environmental niches. Intriguingly, recent studies have shown that both originate from same myeloid progenitor during yolk sac hematopoiesis, but developmental fates diverge within brain. Several works partially unveiled mechanisms orchestrating development of mice humans; however, many questions remain unanswered. Defining molecular underpinnings controlling transcriptional epigenetic programs is one upcoming challenges for field. In this review, we outline current knowledge on ontogeny, phenotypic diversity, factors shaping ecosystem macrophages. We discuss insights garnered human studies, highlighting similarities differences compared mice. Lastly, address research gaps potential future directions Understanding how communicate with local environment tissue instructs trajectories functional features essential fully comprehend physiology disease.
Язык: Английский
Процитировано
1
Neuron, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
Brain Behavior and Immunity, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
6
Nature reviews. Immunology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 31, 2025
Язык: Английский
Процитировано
0
Nature reviews. Immunology, Год журнала: 2025, Номер unknown
Опубликована: Май 2, 2025
Язык: Английский
Процитировано
0
Multiple Sclerosis Journal, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 6, 2024
The pathophysiology of multiple sclerosis (MS) remains poorly understood despite decades tremendous research efforts. Advances in neuroradiography coupled with availability unbiased approaches including spatial transcriptomics, proteomics, metabolomics, and lipidomics that are compatible brain fluid specimens from patients raise hope discovery novel disease drivers is on the horizon. Once thought to be little more than salty bathwater, our modern understanding cerebrospinal (CSF) suggests CSF as a compelling, critical regulator function health disease. Recent studies field have reinvigorated interest medium better understand MS deliver disease-modifying therapies. In turn, choroid plexus, an epithelial tissue located within each ventricle regulates forms key blood-CSF barrier, uniquely positioned orchestrate neuroinflammation associated MS. this perspective review, we will discuss what known about plexus conductor immune responses how it may propagate via CSF.
Язык: Английский
Процитировано
3
STAR Protocols, Год журнала: 2025, Номер 6(1), С. 103627 - 103627
Опубликована: Фев. 27, 2025
Язык: Английский
Процитировано
0
Current Opinion in Immunology, Год журнала: 2025, Номер 93, С. 102540 - 102540
Опубликована: Фев. 27, 2025
Язык: Английский
Процитировано
0
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Фев. 28, 2025
The choroid plexus (CP) plays a critical role in maintaining central nervous system (CNS) homeostasis, producing cerebrospinal fluid, and regulating the entry of specific substances into CNS from blood. CP dysfunction has been implicated various neurological psychiatric disorders, including Alzheimer's disease, Parkinson's multiple sclerosis. This study investigates relationship between structural integrity cognitive decline normative aging, using advanced magnetic resonance imaging techniques, volume, diffusion tensor indices (mean diffusivity, MD, fractional anisotropy, FA) relaxometry metrics (longitudinal, T 1 , transverse, 2 relaxation times). Our results show that diminished microstructural integrity, as reflected by higher MD values, or lower FA is associated with performance processing speed fluency. Notably, measures demonstrated greater sensitivity to than macrostructural measures, i.e. volume. Longitudinal analysis revealed individuals reduced exhibit steeper over time. Furthermore, equation modeling latent variable representing predicts faster overall decline, an effect size comparable age. These findings highlight importance health suggest holistic approach assessing could serve sensitive biomarker for early detection decline. Further research needed elucidate mechanisms underlying explore potential therapeutic implications targeting function prevent treat age-related deficits.
Язык: Английский
Процитировано
0