Vaccines,
Год журнала:
2024,
Номер
12(12), С. 1436 - 1436
Опубликована: Дек. 20, 2024
The
concept
of
"platform
technology"
gained
prominence
after
the
Ebola
outbreak
and
since
then
has
become
essential
to
international
vaccine
(prophylactic
vaccines
against
infectious
disease)
regulatory
frameworks.
Its
significance
was
further
amplified
during
COVID-19
pandemic,
where
platform
technology
enabled
rapid
development
approval
vaccines,
optimizing
processes,
enhancing
global
public
health
responses.
As
a
transformative
tool,
streamlines
product
development,
allowing
for
reduction
in
number
clinical
trials
or
exemption
from
certain
facilitating
cross-referencing
submissions.
Despite
significant
efforts
establish
standardized
procedures,
challenges
remain,
particularly
achieving
unified
definition
application
across
regions.
This
paper
explores
evolution,
applications,
strategies
technology,
with
focus
on
China's
experience
this
field.
approach,
encompassing
risk
assessment,
expedited
emergency
offers
valuable
insights
into
coordination.
By
analyzing
contributions
practices,
highlights
potential
address
future
pandemics,
including
"Pathogen
X",
underscores
importance
harmonizing
strengthen
preparedness
response.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 3, 2024
Abstract
The
success
of
the
live
attenuated
Yellow
Fever
vaccine
(YF17D)
that
elicits
immunity
lasting
over
thirty
years
has
made
it
a
widely
used
model
to
understand
generation
durable
protection.
We
compare
early
single-cell
level
transcriptional
response
in
mice
YF17D
and
an
adjuvanted-inactivated,
but
less
effective
version
(InYF).
Within
first
week,
we
identify
70
kinetic
patterns
45
cellular
clusters,
majority
which
discriminate
between
two
formulations,
some
tissue
sex-specific
manner.
Intriguingly,
differential
transcripts
fall
into
categories,
one
whose
association
with
or
InYF
is
maintained
even
when
decoupled
from
their
cell-type
expression
other
where
such
cell-plus-gene
pairing
critical
maintain
marker
status.
demonstrate
applications
this
resource,
by
identifying
B
cells
varied
interferon
antigen
responsiveness
relation
each
vaccine.
This
high-resolution
dataset
amenable
further
biomarker
discovery
hypothesis
generation.
Liver International,
Год журнала:
2024,
Номер
45(1)
Опубликована: Дек. 14, 2024
ABSTRACT
Vaccines
are
the
most
effective
tool
against
COVID‐19
and
generally
safe.
Very
rare
heterogeneous
cases
of
acute
liver
injury
associated
to
all
types
SARS‐CoV‐2
vaccines
have
been
reported,
mostly
with
autoimmune
features.
Epidemiological
studies
used
diagnostic
criteria
included
different
populations.
Immunological
in
selected
linked
mRNA
suggest
that
it
has
a
unique
pathophysiology,
vaccine‐encoded
spike
protein
playing
central
role
triggering
aberrant
immune
response.
In
series,
was
observed
more
often
following
second
vaccine
dose.
Latency
from
vaccination
diagnosis
hepatitis
1–147
days
after
last
Raised
immunoglobulin
G
levels
positive
anti‐nuclear
and/or
anti‐smooth
muscle
antibodies
frequent.
The
vast
majority
reported
treated
corticosteroids,
azathioprine.
Outcome
is
favourable,
but
requiring
transplantation
or
causing
death
reported.
clinical
entity
includes
patients
long‐term
immunosuppression,
similarly
hepatitis,
self‐limiting
damage,
possibly
representing
form
autoimmune‐like
which
we
being
referred
as
vaccine‐associated
(SVALI).
Further
needed
investigate
pathogenic
mechanisms
related
response
viral
liver.
Vaccines,
Год журнала:
2024,
Номер
12(12), С. 1436 - 1436
Опубликована: Дек. 20, 2024
The
concept
of
"platform
technology"
gained
prominence
after
the
Ebola
outbreak
and
since
then
has
become
essential
to
international
vaccine
(prophylactic
vaccines
against
infectious
disease)
regulatory
frameworks.
Its
significance
was
further
amplified
during
COVID-19
pandemic,
where
platform
technology
enabled
rapid
development
approval
vaccines,
optimizing
processes,
enhancing
global
public
health
responses.
As
a
transformative
tool,
streamlines
product
development,
allowing
for
reduction
in
number
clinical
trials
or
exemption
from
certain
facilitating
cross-referencing
submissions.
Despite
significant
efforts
establish
standardized
procedures,
challenges
remain,
particularly
achieving
unified
definition
application
across
regions.
This
paper
explores
evolution,
applications,
strategies
technology,
with
focus
on
China's
experience
this
field.
approach,
encompassing
risk
assessment,
expedited
emergency
offers
valuable
insights
into
coordination.
By
analyzing
contributions
practices,
highlights
potential
address
future
pandemics,
including
"Pathogen
X",
underscores
importance
harmonizing
strengthen
preparedness
response.
