Co-administration of seasonal quadrivalent influenza and COVID-19 vaccines leads to enhanced immune responses to influenza virus and reduced immune responses to SARS-CoV-2 in naive mice

Vaccine, Год журнала: 2025, Номер 50, С. 126825 - 126825

Опубликована: Фев. 7, 2025

Язык: Английский

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CRISPR-Cas: a game-changer in vaccine development and the fight against viral infections

Trends in Microbiology, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Co-Administration of Seasonal Quadrivalent Influenza and Covid-19 Vaccines Leads to Enhanced Immune Responses to Influenza Virus and Reduced Immune Responses to Sars-Cov-2 in Naive Mice

Опубликована: Янв. 1, 2024

Язык: Английский

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A Harmless Avian Vaccine Virus Could Be Developed into an Off-the-Shelf “Antibiotic” for Viruses

Qeios, Год журнала: 2024, Номер 6(11)

Опубликована: Ноя. 14, 2024

A repurposed apathogenic double stranded (ds) RNA vaccine virus, the infectious bursal disease virus (IBDV), significantly upregulates expressions of type I interferon (IFN) genes. IBDV superinfection therapy (SIT) has been proven to be safe and effective against hepatitis A, B, C viruses (HAV, HBV, HCV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), herpes zoster (HZV). might used control most infections before adaptive immunity develops. The safety efficacy a reverse engineered new viral drug candidate, strain R903/78, could reconfirmed in patients short-term Phase I/II study. With an off-the-shelf, stockpiled R903/78 drug, many millions deaths repeat US$12 trillion world spent on COVID-19 mitigated.

Язык: Английский

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A wide diversity of viruses detected in African mammals involved in the wild meat supply chain

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 30, 2024

ABSTRACT The processes involved in acquiring, trading, preparing, and consuming wild meat pose significant risks for the emergence of zoonotic infectious diseases. Several major viral outbreaks have been directly linked to supply chain, yet our knowledge virome many mammals this chain remains limited disproportionately focused on certain mammalian taxa pathogens. This report presents findings a metagenomic screening 99 specimens belonging 27 African mammal species one domesticated species, all traded their meat. study focuses tissue swab samples collected from various regions Democratic Republic Congo Brussels, Belgium. A total fifteen virus strains were detected, families Arteriviridae , Retroviridae Sedoreoviridae (primates), Picobirnaviridae (primates rodents), Picornaviridae (rodents), Hepadnaviridae (hyrax), Orthoherpesviridae (artiodactylid carnivore) Spinareoviridae (carnivore). detected hosts first time, expanding host range genetic diversity. Of note is presence viruses genetically related recognised pathogens, i.e., human picobirnavirus ( Orthopicobirnavirus hominis ) simian foamy Simiispumavirus rotavirus Rotavirus alphagastroenteritidis (primates). these primates concerning as non-human are phylogenetically closely humans, which can facilitate interspecies transmission. These underscore high diversity potential risk infection through cross-species transmission during close interactions with wildlife chain.

Язык: Английский

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Concluding Remarks for the Special Issue on RNA Viruses and Antibody Response, Second Edition

Viruses, Год журнала: 2024, Номер 16(11), С. 1678 - 1678

Опубликована: Окт. 28, 2024

The emergence and re-emergence of RNA viruses pose a constant, significant global health problem [...]

Язык: Английский

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A Harmless Avian Vaccine Virus Could Be Developed into an Off-the-Shelf “Antibiotic” for Viruses

Опубликована: Окт. 29, 2024

A repurposed apathogenic double stranded (ds) RNA vaccine virus, the infectious bursal disease virus (IBDV), significantly upregulates expressions of type I interferon (IFN) genes. IBDV superinfection therapy (SIT) has been proven to be safe and effective against hepatitis A, B, C viruses (HAV, HBV, HCV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), herpes zoster (HZV). might used control most infections before adaptive immunity develops. The safety efficacy a reverse engineered new viral drug candidate, strain R903/78, could reconfirmed in patients short-term Phase I/II study. With an off-the-shelf, stockpiled R903/78 drug, many millions deaths repeat US$12 trillion world spent on COVID-19 mitigated.

Язык: Английский

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Metagenomic Analyses of Water Samples of Two Urban Freshwaters in Berlin, Germany, Reveal New Highly Diverse Invertebrate Viruses

Microorganisms, Год журнала: 2024, Номер 12(11), С. 2361 - 2361

Опубликована: Ноя. 19, 2024

In an attempt to explore the RNA viromes of two German rivers, we searched virus particle contents one 50 L water sample each from Teltow Canal and Havel River for viruses assumed infect invertebrates. More than 330 complete partial genomes up a length 37 kb were identified, with noda-like reo-like being most abundant, followed by bunya-like birna-like viruses. Viruses related

Язык: Английский

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Infection-related pathway activation and vulnerability to arsenic trioxide in acute promyelocytic leukemia with TTMV::RARA

Leukemia, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 28, 2024

Язык: Английский

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Artificial intelligence for disease X: Progress and challenges

Journal of Translational Internal Medicine, Год журнала: 2024, Номер 12(6), С. 534 - 536

Опубликована: Дек. 1, 2024

Язык: Английский

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