Dietary caloric input and tumor growth accelerate senescence and modulate liver and adipose tissue crosstalk

Communications Biology, Год журнала: 2025, Номер 8(1)

Опубликована: Янв. 7, 2025

Metabolic alterations are related to tumorigenesis and other age-related diseases that accelerated by "Westernized" diets. In fact, hypercaloric nutrition is associated with an increased incidence of cancers faster aging. Conversely, lifespan-extending strategies, such as caloric restriction, impose beneficial effects on both processes. Here, we investigated the metabolic consequences hypercaloric-induced aging tumor growth in female mice. Our findings indicate a high-fat high-sucrose diet increases mainly due boosted oxidation glucose fatty acids. Consequently, through expression lactate, IGFBP3, PTHLH, tumors modulate liver white adipose tissue metabolism. liver, induced fibrosis accelerates senescence process, despite lower systemic pro-inflammatory state. Importantly, induces wasting browning tissue, thereby reversing diet-induced insulin resistance. Finally, suggest alters liver-adipose crosstalk upregulates Fgf21, senescence, negatively modulates lipids carbohydrates metabolism even caloric-restricted-fed Physiological responses different dietary regimens process and, consequently, biology tissues, WAT during growth.

Язык: Английский

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Lymph nodes link sex-biased immune aging to compromised antigen recognition

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 15, 2025

A diverse naive CD8 T cell repertoire is essential to provide broad protection against infection and cancer. Aging diminishes cells, reducing potential diversity leading lymph node contraction. Here, we revealed that this decline occurs earlier in males, resulting significant sex differences immunity during middle age. Earlier life, cells males become virtual memory prone premature senescence. Due androgen-driven thymic atrophy naïve are insufficiently replenished. Therapeutic thymus rejuvenation via testosterone ablation restored nodes of middle-aged male mice, enhanced tumor recognition. These findings show the crucial role age on repertoires suggest strategies restore immune function aging.

Язык: Английский

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Proteogenomic Profiling of Treatment-Naïve Metastatic Malignant Melanoma

Cancers, Год журнала: 2025, Номер 17(5), С. 832 - 832

Опубликована: Фев. 27, 2025

Melanoma is a highly heterogeneous disease, and deeper molecular classification essential for improving patient stratification treatment approaches. Here, we describe the histopathology-driven proteogenomic landscape of 142 treatment-naïve metastatic melanoma samples to uncover subtypes clinically relevant biomarkers. We performed an integrative analysis identify proteomic subtypes, assess impact BRAF V600 mutations, study profiles cellular composition tumor microenvironment. Clinical histopathological data were used support findings related tissue morphology, disease progression, outcomes. Our revealed five distinct that integrate immune stromal microenvironment components correlate with clinical parameters. demonstrated V600-mutated melanomas exhibit biological heterogeneity, where oncogene-induced senescence-like phenotype associated improved survival. This led proposed mortality risk-based may contribute more personalized strategies. Furthermore, strongly correlated progression outcomes, highlighting connective tissue-to-tumor ratio assessment as potential decision-making tool. identified melanoma-associated SAAV signature linked extracellular matrix remodeling SAAV-derived neoantigens targets anti-tumor responses. provides comprehensive melanoma, integrating insights features. The aid in development tailored diagnostic therapeutic strategies, management

Язык: Английский

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The complex interplay between aging and cancer

Nature Aging, Год журнала: 2025, Номер unknown

Опубликована: Март 4, 2025

Язык: Английский

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Engineered cell nanovesicle antagonists for androgen deprivation therapy of melanoma

Journal of Colloid and Interface Science, Год журнала: 2025, Номер unknown, С. 137468 - 137468

Опубликована: Март 1, 2025

Язык: Английский

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Desmosome mutations in keratinocytes fuel melanoma development

Nature Genetics, Год журнала: 2025, Номер unknown

Опубликована: Апрель 16, 2025

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What is the optimal first-line regimen for advanced non-small cell lung cancer patients with epidermal growth factor receptor mutation: a systematic review and network meta-analysis

BMC Pulmonary Medicine, Год журнала: 2024, Номер 24(1)

Опубликована: Дек. 18, 2024

There are currently various tyrosine kinase inhibitor (TKI)-based regimens available, and it can be challenging for clinicians to determine the most effective safe option due lack of direct comparisons between these regimens. In this study, we conducted a network meta-analysis comparing efficacy safety distinct optimal regimen patients with EGFR-mutated non-small cell lung cancer, thereby facilitating clinical decision-making. The PubMed, Embase, Cochrane Library databases international conference were comprehensively searched from their inception 02 April 2024 collecting data regarding eligible randomized controlled trials (RCTs). Following literature screening extraction, NMA was compare among 21 random-effects consistency model in Bayesian framework using Markov Chain Monte Carlo simulation technique within GEMTC package. A total 35 RCTs included, involving 9718 individuals Compared other interventions, combination therapies based on third-generation TKIs, especially osimertinib plus ramucirumab, showed favorable PFS prolongation overall patients. Consistently, subgroup analyses that TKIs-based superior prespecified subgroups clinicopathological characteristics. terms survival, despite TKIs also showing relatively outcomes, erlotinib chemotherapy gefitinib ranked more favorably. profile, did not significantly increase incidence grade 3 or higher adverse events compared Our study concluded (osimertinib chemotherapy, bevacizumab, amivantamab lazertinib aumolertinib apatinib) could new clinically preferable first-line, standard care advanced cancer. protocol registered Prospective Register Systematic Reviews (PROSPERO CRD42023480596).

Язык: Английский

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Sex-specific and sex hormonal-related differences in melanoma microenvironment

EJC Skin Cancer, Год журнала: 2024, Номер unknown, С. 100266 - 100266

Опубликована: Сен. 1, 2024

Язык: Английский

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Male melanoma comes of age

Nature reviews. Cancer, Год журнала: 2024, Номер 24(11), С. 742 - 742

Опубликована: Окт. 10, 2024

Язык: Английский

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