Energy metabolism in health and diseases

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Фев. 18, 2025

Язык: Английский

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Recommendations for mitochondria transfer and transplantation nomenclature and characterization

Nature Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

Язык: Английский

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An Energy Metabolism Nanoblocker for Cutting Tumor Cell Respiration and Inhibiting Mitochondrial Hijacking from Cytotoxic T Lymphocyte

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 16, 2025

Abstract Energy metabolism modulation emerges as a highly regarded strategy for tumor therapy. However, the efficacy of targeting energy in cells remains unsatisfactory due to alternate production pathways by switching between mitochondrial respiration and glycolysis. In addition, can hijack mitochondria from peripheral immune maintain their an extra respiratory pathway. this study, CD44 receptor‐targeted hyaluronic acid nanoblocker is developed achieve bidirectional blockade basal with loaded oxidative phosphorylation (OXPHOS) inhibitor nebivolol hydrochloride, glycolysis 3‐bromopyruvate. Furthermore, combined intraperitoneal injection L‐778123 hydrochloride inhibits transfer, thus blocking pathway depletion cytotoxic T lymphocytes. This emerging strategy, which involves depleting cell through inhibition (OXPHOS/glycolysis) respiration, while synergistically enhancing effector systemic anti‐tumor effects, demonstrates high safety both vitro vivo experiments. It provides conceptual paradigm shift nanomedicine‐mediated metabolism‐based

Язык: Английский

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Horizontal mitochondrial transfer in cancer biology: Potential clinical relevance

Cancer Cell, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Mitochondrial swap from cancer to immune cells thwarts anti-tumour defences

Nature, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Язык: Английский

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Osteoblast‐Derived Mitochondria Formulated with Cationic Liposome Guide Mesenchymal Stem Cells into Osteogenic Differentiation

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 31, 2025

Abstract While mitochondria are known to be essential for intracellular energy production and overall function, emerging evidence highlights their role in influencing cell behavior through mitochondrial transfer. This phenomenon provides a potential basis the development of treatment strategies tissue damage degeneration. study aims evaluate whether isolated from osteoblasts can promote osteogenic differentiation mesenchymal stem cells (MSCs). Mitochondria MSCs, which primarily utilize glycolysis, compared with those MG63 cells, depend on oxidative phosphorylation. both types then encapsulated cationic liposomes transferred impact is assessed. delivery MSCs grown two‐ three‐dimensional cultures results increased expression markers, including Runt‐related transcription factor 2, Osterix, Osteopontin, upregulation genes involved Bone morphogenetic protein 2 signaling calcium import. accompanied by influx regulated Wnt/β‐catenin pathway. Transplantation spheroids containing MG63‐derived bone defect animal models improves regeneration. The suggest that effectively guides toward osteogenesis, paving way mitochondria‐transplantation therapies.

Язык: Английский

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Modulating lipid metabolism improves tumor immunotherapy

Journal for ImmunoTherapy of Cancer, Год журнала: 2025, Номер 13(2), С. e010824 - e010824

Опубликована: Фев. 1, 2025

Immunotherapy has progressed significantly in cancer treatment; however, several factors influence its outcomes. Abnormal lipid metabolism, which is frequently observed cancers, promotes tumor proliferation, invasion, and metastasis. Li et al from the Medical Oncology Department of Chongqing University Cancer Hospital constructed a metabolism scoring system reported that MK1775 inhibited fatty acid oxidation tumor-associated macrophages reduced T-cell infiltration, further enhancing efficacy immunotherapy. This study demonstrated critical role Currently, lipids, such as acids, phospholipids, cholesterol, been to affect microenvironment by regulating immune cells, including T natural killer macrophages. These metabolic changes can impair immunotherapy, resulting progression. Consequently, emerges an important regulator for improving immunotherapeutic outcomes provides novel powerful strategy combination therapy.

Язык: Английский

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Restoring the supply lines: removing roadblocks to fatty acid uptake enhances T cell-driven cancer fight

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Фев. 13, 2025

Язык: Английский

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Bone Marrow CD8 + Abundance Inversely Correlates with Progressive Marrow Fibrosis and Myelodysplastic Evolution in GATA2 Deficiency: Case Report

Journal of Clinical Immunology, Год журнала: 2025, Номер 45(1)

Опубликована: Фев. 20, 2025

GATA2 deficiency, a rare inborn error of immunity, presents with highly variable phenotypes. Bone marrow (BM) changes such as hypocellularity and myelodysplastic syndrome (MDS) are common, hematopoietic stem cell transplantation being the only curative option due to risk progression acute myeloid leukemia. Although traditional markers like cytogenetic abnormalities somatic mutations (e.g., ASXL1) identify leukemic transformation, efforts novel predictors disease evolution needed. CD8+ T cells known play key role in MDS immune surveillance, but their specific involvement deficiency remains poorly defined. In this case report, we report on young adult who underwent longitudinal monitoring both peripheral BM lymphocyte subsets, focus T-cell relation progression. The patient exhibited typical GATA2-deficient immune-hematological findings, including monocytopenia, B- NK-cell had no history severe infections remained transfusion-independent. While levels stable over time, notable reduction was observed association Providing long-term follow-up one patient, suggest that decrease may serve an early marker surveillance escape These findings underscore need for further investigation into evolution, potentially offering new insights therapeutic intervention.

Язык: Английский

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Environmental Drivers of Malignant Clonal Selection in Precancerous Lesion Evolution

Cell Proliferation, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

ABSTRACT Somatic mutations accumulation and subsequent malignant clonal selection are the processes that lead to cancer. The intricacy includes exposure carcinogens as well ways in which these exposures interact with genetic, polygenic, or epigenetic predispositions. It is worthwhile investigate how environmental factors influence initial transformation of healthy cells into ones, their effects on promoting growth, invasion, immune evasion, inflammation drug resistance onset cancerous cells.

Язык: Английский

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