International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142824 - 142824
Опубликована: Апрель 1, 2025
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(1), С. 415 - 415
Опубликована: Янв. 6, 2025
Cancer is a complex genetic disorder characterized by abnormalities in both coding and regulatory non-coding RNAs. microRNAs (miRNAs) are key RNAs that modulate cancer development, functioning as tumor suppressors oncogenes. miRNAs play critical roles progression, influencing processes such initiation, promotion, metastasis. They exert their effects targeting suppressor genes, thereby facilitating while also inhibiting oncogenes to prevent further disease advancement. The miR-10 family, particularly miR-10a-5p miR-10b-5p (miR-10a/b-5p), notably involved progression. Intriguingly, functions can differ across different cancers, sometimes promoting at other times suppressing growth depending on the type target genes. This review explores dual of miR-10a/b-5p tumor-suppressive (TSmiRs) or oncogenic (oncomiRs) various cancers examining molecular cellular mechanisms impact microenvironment. Furthermore, we discuss potential therapeutic targets, emphasizing miRNA-based strategies for treatment. insights discussed this aim advance our understanding miR-10a/b-5p’s biology application developing innovative therapies.
Язык: Английский
Процитировано
1
Pharmacological Research, Год журнала: 2025, Номер 212, С. 107596 - 107596
Опубликована: Янв. 10, 2025
Sepsis is a life-threatening syndrome characterized by organ dysfunction caused dysregulated host response to infection. Sepsis-associated acute liver injury (SA-ALI) frequent and serious complication of sepsis that considerably impacts both short-term long-term survival outcomes. In intensive care units (ICUs), the mortality rate patients with SA-ALI remains high, mostly due absence effective early diagnostic markers suitable therapeutic strategies. Recent studies have demonstrated importance non-coding RNAs (ncRNAs) in development progression SA-ALI. This review focuses on critical roles ncRNAs, including microRNAs (miRNAs), long (lncRNAs), circular (circRNAs), regulating "cytokine storms", oxidative stress, mitochondrial dysfunction, programmed cell death SA-ALI, summarizes current state limitations existing lncRNAs circRNAs By integrating advancements high-throughput sequencing technologies, this provides novel insights into dual potential ncRNAs as biomarkers targets, offers new ideas for diagnosis treatment research highlights challenges clinical translation.
Язык: Английский
Процитировано
1
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 21, 2025
Abstract Recent advancements in microRNAs (miRNAs) research have revealed their key roles both normal physiological processes and pathological conditions, leading to potential applications diagnostics therapeutics. However, the path forward is fraught with several scientific technical challenges. This review article briefly explores milestones of discovery, biogenesis, functions, application for clinical diagnostic therapeutic strategies miRNAs. The challenges future directions are also discussed fully harness capabilities.
Язык: Английский
Процитировано
1
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 2, 2025
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 710 - 710
Опубликована: Янв. 16, 2025
MicroRNA-200c (miR-200c) is increasingly recognized as a crucial small RNA molecule that plays significant and multifaceted role in the complex processes of tumor development, invasion, metastasis across various types cancers. Recent studies have compellingly demonstrated miR-200c exerts its influence on biology by meticulously regulating range critical processes, including cell proliferation, apoptosis, epithelial-mesenchymal transition (EMT), migration, all which are essential for progression aggressiveness tumors. This comprehensive review aims to summarize expression characteristics functional implications diverse array types, delving into potential utility both biomarker early detection therapeutic target realm cancer treatment. By synthesizing current research findings insights, we aspire provide valuable information could significantly enhance diagnostic capabilities inform strategic development targeted therapy approaches oncology.
Язык: Английский
Процитировано
0
Viruses, Год журнала: 2025, Номер 17(2), С. 153 - 153
Опубликована: Янв. 23, 2025
Long non-coding RNAs (lncRNAs) have been recognized for their crucial roles in the replication processes of various viruses. However, specific functions and regulatory mechanisms many lncRNAs influenza A virus (IAV) pathogenesis remain poorly understood. In this study, we identified lncRNA THRIL observed a significant reduction its expression following IAV infection A549 cells. The treatment cells with viral mimic poly (I:C), or type I III interferons, resulted substantial decrease expression. Furthermore, overexpression significantly enhanced replication, while silencing markedly reduced replication. Additionally, led to notable reductions levels interferons cell lines overexpressing compared control groups; conversely, knockdown exhibited higher interferon than groups. Moreover, was found inhibit several critical interferon-stimulated genes (ISGs), which are essential an effective antiviral response. Notably, our findings demonstrated that impaired activation IRF3, key transcription factor signaling pathway, thereby suppressing host innate immunity. These results highlight THRIL’s potential as therapeutic target strategies.
Язык: Английский
Процитировано
0
FEBS Letters, Год журнала: 2025, Номер 599(2), С. 143 - 146
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Янв. 27, 2025
Abstract Motivation Despite significant advances in spatial transcriptomics, the analysis of formalin-fixed paraffin-embedded (FFPE) tissues, which constitute most clinically available samples, remains challenging. Additionally, capturing both coding and noncoding RNAs a context poses challenges. We recently introduced Patho-DBiT, technology designed to address these unmet needs. However, marked differences between Patho-DBiT existing transcriptomics protocols necessitate specialized computational tools for comprehensive whole-transcriptome FFPE samples. Results Here, we present ASTRO, an automated pipeline developed process data. In addition supporting standard datasets, ASTRO is optimized analyses enabling detection various RNA species, including non-coding such as miRNAs. To compensate reduced quality incorporates filtering step optimizes barcode calling, increasing mapping rate. These optimizations allow spatially quantify species entire transcriptome achieve robust performance Availability Codes are at GitHub ( https://github.com/gersteinlab/ASTRO ).
Язык: Английский
Процитировано
0
Frontiers in Genetics, Год журнала: 2025, Номер 16
Опубликована: Фев. 7, 2025
Non-coding ncRNAs (ncRNAs) are transcriptional production which do not coding proteins, with a spectrum of diversified type, and function (Chen Kim, 2024). Although the have many types including long noncoding RNAs (lncRNAs), microRNAs (miRNAs), small nucleolar (snoRNAs), transfer RNA (tRNA), ribosomal (rRNA), circular (circRNA) etc., most them lncRNA miRNA. In 1984, first regulatory ncRNA, microRNA F (micF) was discovered from E. coli. MicF inhibits translation OmpF by binding to its ribosome-binding site, blocking ribosome entry (Mizuno et al., 1984;Corcoran 2012).Over past 40 years, numerous non-coding (ncRNAs), such as Let-7, enod40, H19, NEAT1, been identified key regulators in animals or plants (Bartolomei 1991;Crespi 1994;Pasquinelli 2000;Hutchinson 2007). Studies demonstrated crucial roles ncRNAs-particularly miRNAs lncRNAs-in development, metabolism, disease (Kallen 2013;Tripathi 2013;Chen However, ncRNA world is still unknown.To provide new insights deeper understanding functional ncRNAs, we curated six articles for "The Non-Coding World Animals Plants" topic. These papers include original research on tobacco, common carp (Cyprinus carpio L.), pulmonary hypertension, well reviews endocrine disorders, eye diseases, intrahepatic cholestasis pregnancy.Xie al. analyzed 549 publicly available RNA-Seq datasets tobacco 30,212 lncRNAs (Xie 2022). exhibit distinct characteristics compared genes, fewer exons, higher A/U content, greater tissue specificity. Functional analysis potential targets these revealed their association nicotine biosynthesis, findings further validated through topping treatment. This study advances our provides candidate genes regulating production.Ledesma-Pacheco presented current regarding miRNAs' mechanism disorders influence biomarkers during development processes overviewing recent significant outputs (Ledesma-Pacheco 2023). review illuminated information related functions diabetes mellitus, thyroid osteoporosis, novel diagnostic therapeutic purposes. It will enhance knowledge facilitate miRNA-based tools disorder.Benavides-Aguilar integrated studies miRNA diseases illustrate eye-related cataracts, glaucoma, macular degeneration (Benavides-Aguilar valuable into applications prognosis treatment disorders.Das 468 raw 28 tissues substitute vertebrate fish model zebrafish, identify using various bioinformatics (Das They conducted lncRNA-miRNA-mRNA interaction network introduced CCncRNAdb, comprehensive web resource (http://backlin.cabgrid.res.in/ccncrnadb/) exploration carp.Xiong consolidates discoveries miRNA, lncRNA, circRNA, etc. pregnancy (ICP) discuss markers, prognostic tools, targets, offering foundation improving early detection personalized ICP (Xiong 2023).Chen peripheral blood samples Pulmonary hypertension (PH) patients healthy individuals whole-genome sequencing transcriptome analysis, exploring role PH By screening differentially expressed miRNAs, they four (hsa-miR-1304-3p, hsa-miR-490-3p, hsa-miR-11400, hsa-miR-31-5p) clinical PH. finding specific mechanisms PH, opening avenues diagnosis precision medicine PH.In summary, expand deepen world.LW, BH, MJH, QZZ all contributed writing revising draft.The author(s) declare that no grant support.
Язык: Английский
Процитировано
0
Probiotics and Antimicrobial Proteins, Год журнала: 2025, Номер unknown
Опубликована: Фев. 15, 2025
Язык: Английский
Процитировано
0