International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142824 - 142824
Опубликована: Апрель 1, 2025
Язык: Английский
Cell Regeneration, Год журнала: 2025, Номер 14(1)
Опубликована: Март 26, 2025
Abstract Accumulated studies have demonstrated that long noncoding RNAs (lncRNAs) play crucial regulatory roles in diverse biological processes, such as embryonic development and cell differentiation. Comprehensive transcriptome analysis identifies extensive lncRNAs, gradually elucidating their functions across various contexts. Recent highlighted the essential role of lncRNAs definitive endoderm differentiation, underscoring importance early development. In this review, we analyzed features overlapping, proximal, desert classified by genomic location, pluripotent stem cells (PSCs) differentiation derivatives. Furthermore, focus on lineage review latest advancements lncRNA identification distinct mechanisms. By consolidating current knowledge, aim to provide a clearer perspective how contribute different manners.
Язык: Английский
Процитировано
0
Journal of Assisted Reproduction and Genetics, Год журнала: 2025, Номер unknown
Опубликована: Март 26, 2025
The paper aims to investigate the biological role of microRNAs secreted by preimplantation embryo into blastocoel fluid and detect a distinctive molecular signature for identifying embryos with highest implantation potential. We carried on multicenter retrospective study involving five European IVF centers. collected 112 samples from day 5 post-fertilization, cultured individually, along data blastocyst grade transfer outcomes. Using custom TLDA Array, we compared expression levels 89 miRNAs between 33 fluids high-quality implanted 30 not-implanted embryos. Expression differences were assessed using SAM t-test. Additionally, correlation function enrichment analysis network construction conducted identify roles deregulated microRNAs. identified six up-regulated in embryos, significantly positively correlated across all (r ≥ 0.7; P ≤ 0.05). They could take part pluripotency circuits, regulating being regulated transcription factors associated stemness, cell growth, development. ROC curve confirmed potential these as classifiers. may represent functional evaluating quality most competent Their evaluation non-invasive genetic testing, integrating epigenetic genomic analyses, enhance allow identification euploid not able implant.
Язык: Английский
Процитировано
0
Developmental Medicine & Child Neurology, Год журнала: 2025, Номер unknown
Опубликована: Март 28, 2025
Neurodevelopmental disorders (NDDs) are a group of brain with neonatal or early childhood onset and lifelong. Various factors including genetics, environmental immune-related risk have been associated NDDs. Given the complex nature these disorders, multiple animal models used to investigate their aetiology underlying cellular molecular mechanisms. Recently, zebrafish attracted great attention as an emerging model for studying In addition easy maintenance, short developmental cycle, ex utero embryonic evolution, optical clarity, successfully recapitulated phenotypes seen in human genetic disorders. This review explores growing role NDD research, by summarizing recently developed autism spectrum disorder, schizophrenia, cerebral palsy. We then explore potential NDDs linked immune system dysfunction.
Язык: Английский
Процитировано
0
Cell Death Discovery, Год журнала: 2025, Номер 11(1)
Опубликована: Апрель 4, 2025
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142824 - 142824
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0