bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2022,
Номер
unknown
Опубликована: Дек. 13, 2022
Early-life
stress
can
have
lifelong
consequences,
enhancing
susceptibility
and
resulting
in
behavioural
cognitive
deficits.
While
the
effects
of
early-life
on
neuronal
function
been
well-described,
we
still
know
very
little
about
contribution
non-neuronal
brain
cells.
Investigating
complex
interactions
between
distinct
cell
types
is
critical
to
fully
understand
how
cellular
changes
manifest
as
deficits
following
stress.
Here,
using
male
female
mice
report
that
induces
anxiety-like
behaviour
fear
generalisation
an
amygdala-dependent
learning
memory
task.
These
were
associated
with
impaired
synaptic
plasticity,
increased
neural
excitability,
astrocyte
hypofunction.
Genetic
perturbation
amygdala
by
either
reducing
calcium
activity
or
network
was
sufficient
replicate
cellular,
synaptic,
Our
data
reveal
a
role
astrocytes
tuning
emotionally
salient
provide
mechanistic
links
stress,
hypofunction,
Summary
Figure
Early-life
stress
can
have
lifelong
consequences,
enhancing
susceptibility
and
resulting
in
behavioural
cognitive
deficits.
While
the
effects
of
early-life
on
neuronal
function
been
well-described,
we
still
know
very
little
about
contribution
non-neuronal
brain
cells.
Investigating
complex
interactions
between
distinct
cell
types
is
critical
to
fully
understand
how
cellular
changes
manifest
as
deficits
following
stress.
Here,
using
male
female
mice
report
that
induces
anxiety-like
behaviour
fear
generalisation
an
amygdala-dependent
learning
memory
task.
These
were
associated
with
impaired
synaptic
plasticity,
increased
neural
excitability,
astrocyte
hypofunction.
Genetic
perturbation
amygdala
by
either
reducing
calcium
activity
or
network
was
sufficient
replicate
cellular,
synaptic,
Our
data
reveal
a
role
astrocytes
tuning
emotionally
salient
provide
mechanistic
links
stress,
hypofunction,
Early-life
stress
can
have
lifelong
consequences,
enhancing
susceptibility
and
resulting
in
behavioural
cognitive
deficits.
While
the
effects
of
early-life
on
neuronal
function
been
well-described,
we
still
know
very
little
about
contribution
non-neuronal
brain
cells.
Investigating
complex
interactions
between
distinct
cell
types
is
critical
to
fully
understand
how
cellular
changes
manifest
as
deficits
following
stress.
Here,
using
male
female
mice
report
that
induces
anxiety-like
behaviour
fear
generalisation
an
amygdala-dependent
learning
memory
task.
These
were
associated
with
impaired
synaptic
plasticity,
increased
neural
excitability,
astrocyte
hypofunction.
Genetic
perturbation
amygdala
by
either
reducing
calcium
activity
or
network
was
sufficient
replicate
cellular,
synaptic,
Our
data
reveal
a
role
astrocytes
tuning
emotionally
salient
provide
mechanistic
links
stress,
hypofunction,
Early-life
stress
can
have
lifelong
consequences,
enhancing
susceptibility
and
resulting
in
behavioural
cognitive
deficits.
While
the
effects
of
early-life
on
neuronal
function
been
well-described,
we
still
know
very
little
about
contribution
non-neuronal
brain
cells.
Investigating
complex
interactions
between
distinct
cell
types
is
critical
to
fully
understand
how
cellular
changes
manifest
as
deficits
following
stress.
Here,
using
male
female
mice
report
that
induces
anxiety-like
behaviour
fear
generalisation
an
amygdala-dependent
learning
memory
task.
These
were
associated
with
impaired
synaptic
plasticity,
increased
neural
excitability,
astrocyte
hypofunction.
Genetic
perturbation
amygdala
by
either
reducing
calcium
activity
or
network
was
sufficient
replicate
cellular,
synaptic,
Our
data
reveal
a
role
astrocytes
tuning
emotionally
salient
provide
mechanistic
links
stress,
hypofunction,
