Food Bioscience, Год журнала: 2025, Номер unknown, С. 106648 - 106648
Опубликована: Апрель 1, 2025
Язык: Английский
Journal of Orthopaedic Translation, Год журнала: 2025, Номер 52, С. 116 - 125
Опубликована: Апрель 12, 2025
Язык: Английский
Процитировано
0
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 20, 2025
The intratumoral microbiota, fatty acid metabolism (FAM), and tumor microenvironment (TME) all provide insights into the management of colon adenocarcinoma (COAD). But biological link among three remains unclear. Here, we analyzed microbiome samples matched host transcriptome from 420 patients with COAD in Cancer Genome Atlas (TCGA). All were divided two subtypes (FAM_high FAM_low) based on Gene set variation analysis (GSVA) score FAM pathway. Furthermore, found significant difference microbiota signatures between subtypes. In-depth suggested that specific microbes tumors may indirectly modify TME, particularly stromal cell populations, by modulating process. More importantly, crosstalk can have a impact prognosis, response to immunotherapy, drug sensitivity patients. Pathological image profiling showed changes TME originating disturbance could be reflected pathological features. In summary, our study provides novel links FAM, COAD, offer guidance for therapeutic opportunities target microbes.
Язык: Английский
Процитировано
0
Redox Biology, Год журнала: 2025, Номер 81, С. 103536 - 103536
Опубликована: Фев. 10, 2025
Язык: Английский
Процитировано
0
Cell Research, Год журнала: 2025, Номер unknown
Опубликована: Фев. 25, 2025
Язык: Английский
Процитировано
0
Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13
Опубликована: Фев. 27, 2025
Ferroptosis and cuproptosis can be summarized as metal-dependent cell death. This study aimed to explore the expression of death resistance (MCDR) characteristics in tumor cells oral squamous carcinoma (OSCC) its relationship with lymph node metastasis (LNM). By integrating single-cell data OSCC from public databases, an matrix comprising 127,149 was constructed. Gene set scores were calculated using irGSEA package, GO KEGG analyses performed identify enriched pathways. The R package monocle3 employed calculate trajectory infer evolutionary patterns. MuSiC2 enable evaluation proportions. Cell-cell interaction information analyzed CellChat package. cathepsin V (CTSV), glutathione peroxidase 4 (GPX4), cyclin-dependent kinase inhibitor 2A (CDKN2A) validated via immunohistochemistry multiplex mucosa (OM), non-metastatic primary tumors (nPT), metastatic (mPT). Additionally, oncoPredict utilized potential drug sensitivities. malignant divided into five subtypes, among which Epi_2 existed more mPT had higher MCDR characteristics. In addition, multiple malignant-related pathways such HEDGEHOG, NOTCH, MYC. spatial transcriptome bulk RNA verified that proportion than nPT. Cell communication analysis showed effect on endothelial enhanced, mainly reflected VEGFR CXCL signaling Immunohistochemical results characteristic markers CTSV GPX4 significantly Multiplex immunohistochemical co-expression CTSV, CDKN2A those patients high may have immunotherapy anti-EGFR treatment resistance. Doramapimod identified a sensitive drug. There is type MDCR OSCC, related LNM It provides predictive marker for early diagnosis LNM.
Язык: Английский
Процитировано
0
Trends in Cell Biology, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Ferroptosis is an iron-dependent cell death pathway that, until recently, has been considered to be dependent on autophagy. However, recent studies have reported conflicting results, raising the question about which contexts determine roles of autophagy in ferroptosis. This opinion article addresses this by summarizing and/or diseases a driver or suppressor The execution ferroptosis depends levels (labile) iron, unsaturated (phospho)lipids and free radicals. We propose that context these three factors their upstream pathways are differentially regulated dictates whether positively negatively regulates
Язык: Английский
Процитировано
0
Developmental Cell, Год журнала: 2025, Номер 60(7), С. 982 - 993
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Proceedings of the National Academy of Sciences, Год журнала: 2025, Номер 122(15)
Опубликована: Апрель 11, 2025
Metastasis is an inefficient process requiring cancer cells to adapt metabolically for survival and colonization in new environments. The contributions of tumor metabolic reprogramming lymph node (LN) metastasis its underlying mechanisms remain elusive. Through single-cell RNA sequencing, we identified rare metastasis-initiating (MICs) with stem-like properties that drive early LN metastasis. Integrated transcriptome, lipidomic, metabolomic, functional analyses demonstrated MICs depend on oxidative phosphorylation (OXPHOS) fueled by fatty acid oxidation (FAO) the lipid-rich microenvironment. Mechanistically, NRF2-SLC7A11 axis promotes glutathione synthesis mitigate stress, thereby enhancing stress resistance metastatic potential MICs. Inhibition reduced sensitized tumors cisplatin. Clinically, elevated expression was observed tumors, high correlating metastasis, chemoresistance, poor prognosis esophageal squamous cell carcinoma (ESCC). These findings highlight pivotal roles FAO-fueled OXPHOS NRF2 suggest targeting these pathways as a promising therapeutic strategy ESCC.
Язык: Английский
Процитировано
0
Food Bioscience, Год журнала: 2025, Номер unknown, С. 106648 - 106648
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0