Transcending life and death: The ultimate cargo of aged neutrophils

Cell, Год журнала: 2025, Номер 188(6), С. 1460 - 1462

Опубликована: Март 1, 2025

Язык: Английский

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Neutrophils release inflammation-resolving vesicles

Nature reviews. Immunology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

Язык: Английский

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Immune cells differentiation in osteoarthritic cartilage damage: friends or foes?

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 25, 2025

Osteoarthritis (OA) is a chronic disease primarily characterized by degenerative changes in articular cartilage and synovitis, for which there are currently no targeted or curative therapies available clinical practice. In recent years, the in-depth analysis of OA using single-cell sequencing immunomics technologies has revealed presence multiple immune cell subsets, as well different differentiation states within same subset, OA. Through immune-immune immune-joint tissue interactions, these cells collectively promote inhibit progression arthritis. This complex network, where “friends foes coexist,” made therapeutic strategies aimed at directly eliminating challenging, highlighting urgent need detailed review composition, distribution, functional heterogeneity, potential, potential risks subsets joint. Additionally, similarities differences between rheumatoid arthritis (RA) terms diagnosis immunotherapy to be precisely understood, order draw lessons from reject RA-based immunotherapies. To this end, summarizes major triggers inflammation OA, characteristics key compares RA treatment. It also outlines current immunomodulatory their limitations. Furthermore, we provide focused discussion on that act foes” arthritis, covering M1/M2 polarization macrophages, heterogeneity neutrophils, unique roles dendritic maturation states, balance pro-inflammatory T regulatory (Tregs), diverse functions B cells, plasma (Bregs) By interpreting clarifies dynamic interactions joints, providing theoretical foundation more precise interventions future

Язык: Английский

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Exomeres and supermeres: Current advances and perspectives

Bioactive Materials, Год журнала: 2025, Номер 50, С. 322 - 343

Опубликована: Апрель 16, 2025

Язык: Английский

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