Exosome-Mediated Cellular Communication in the Tumor Microenvironment Imparts Drug Resistance in Breast Cancer DOI Open Access
Rama Rao Malla,

Priyamvada Bhamidipati,

Anuveda Sree Samudrala

и другие.

Cancers, Год журнала: 2025, Номер 17(7), С. 1167 - 1167

Опубликована: Март 30, 2025

Globally, breast cancer (BC) is the leading cause of cancer-related death for women. BC characterized by heterogeneity, aggressive behavior, and high metastatic potential. Chemotherapy, administered as monotherapy or adjuvant therapy, remains a cornerstone treatment; however, acquired drug resistance significant clinical challenge. Deciphering mechanisms will be central to developing more efficient treatment options improving patient outcomes. The current review examines multifaceted nature exosomes in conferring through complex communication networks within tumor microenvironment. We further explore recent advances understanding how contribute against established chemotherapeutic agents such tamoxifen, paclitaxel, doxorubicin, platinum-based drugs, trastuzumab, newer immunotherapies, immune checkpoint inhibitors. Moreover, we discuss existing systematic approaches investigating exosome-drug relationship BC. Finally, promising therapeutic overcome exosome-dependent BC, highlighting potential avenues improved efficacy. Investigating distinct functions cargo offers innovative overcoming resistance.

Язык: Английский

Exosome-Mediated Cellular Communication in the Tumor Microenvironment Imparts Drug Resistance in Breast Cancer DOI Open Access
Rama Rao Malla,

Priyamvada Bhamidipati,

Anuveda Sree Samudrala

и другие.

Cancers, Год журнала: 2025, Номер 17(7), С. 1167 - 1167

Опубликована: Март 30, 2025

Globally, breast cancer (BC) is the leading cause of cancer-related death for women. BC characterized by heterogeneity, aggressive behavior, and high metastatic potential. Chemotherapy, administered as monotherapy or adjuvant therapy, remains a cornerstone treatment; however, acquired drug resistance significant clinical challenge. Deciphering mechanisms will be central to developing more efficient treatment options improving patient outcomes. The current review examines multifaceted nature exosomes in conferring through complex communication networks within tumor microenvironment. We further explore recent advances understanding how contribute against established chemotherapeutic agents such tamoxifen, paclitaxel, doxorubicin, platinum-based drugs, trastuzumab, newer immunotherapies, immune checkpoint inhibitors. Moreover, we discuss existing systematic approaches investigating exosome-drug relationship BC. Finally, promising therapeutic overcome exosome-dependent BC, highlighting potential avenues improved efficacy. Investigating distinct functions cargo offers innovative overcoming resistance.

Язык: Английский

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