IRE1α-mediated UPR activation in gastrointestinal cancers: adaptive mechanisms and therapeutic potential

Drug Discovery Today, Год журнала: 2025, Номер unknown, С. 104335 - 104335

Опубликована: Март 1, 2025

Язык: Английский

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The role of the master cancer regulator Pin1 in the development and treatment of cancer

Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Апрель 30, 2024

This review examines the complex role of Pin1 in development and treatment cancer. is only peptidyl–prolyl isomerase (PPIase) that can recognize isomerize phosphorylated Ser/Thr-Pro peptide bonds. catalyzes a structural change motifs modulate protein function thereby impact cell cycle regulation tumorigenesis. The molecular mechanisms by which contributes to oncogenesis are reviewed, including overexpression its correlation with poor cancer prognosis, contribution aggressive tumor phenotypes involved therapeutic resistance discussed, an emphasis on stem cells, epithelial-to-mesenchymal transition (EMT), immunosuppression. potential inhibition along promise difficulties identifying potent, drug-like, small-molecule inhibitors. available evidence supports efficacy targeting as novel analyzing network cancer-driving pathways illustrating synergistic drug combinations inhibitors for treating drug-resistant tumors.

Язык: Английский

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Pin1-catalyzed conformational regulation after phosphorylation: A distinct checkpoint in cell signaling and drug discovery

Science Signaling, Год журнала: 2024, Номер 17(841)

Опубликована: Июнь 18, 2024

Protein phosphorylation is one of the most common mechanisms regulating cellular signaling pathways, and many kinases phosphatases are proven drug targets. Upon phosphorylation, protein functions can be further regulated by distinct isomerase Pin1 through cis-trans isomerization. Numerous targets important roles have now been elucidated for Pin1. However, no tools available to detect or target cis trans conformation events in cells. The development inhibitors stereo- phospho-specific antibodies has revealed that conformations often opposing functions. Aberrant conformational changes due dysregulation drive pathogenesis but effectively targeted age-related diseases, including cancers neurodegenerative disorders. Here, we review advances understanding health disease highlight regulation as a signal transduction checkpoint treatment.

Язык: Английский

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Beyond protein folding: The pleiotropic functions of PPIases in cellular processes and microbial virulence

Biochimica et Biophysica Acta (BBA) - General Subjects, Год журнала: 2024, Номер unknown, С. 130754 - 130754

Опубликована: Дек. 1, 2024

Язык: Английский

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