CircArid4b: A novel circular RNA regulating antibacterial response during hypoxic stress via apoptosis in yellow catfish (Pelteobagrus fulvidraco)
Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology,
Год журнала:
2025,
Номер
289, С. 110121 - 110121
Опубликована: Янв. 7, 2025
Язык: Английский
Identification of Anoikis‐Related Genes in Gastric Cancer: Bioinformatics and Experimental Validation
Cancer Medicine,
Год журнала:
2025,
Номер
14(8)
Опубликована: Апрель 1, 2025
ABSTRACT
Introduction
Distant
metastasis
is
the
main
reason
for
poor
prognosis
of
gastric
cancer,
and
anoikis
refers
to
cell
death
caused
when
cells
detach
from
extracellular
matrix
or
adhere
in
incorrect
locations,
playing
an
important
role
distant
cancer.
Methods
Download
TCGA‐STAD
dataset
gene
set,
filter
out
differentially
expressed
genes.
Perform
consensus
clustering
cancer
samples,
conduct
Weighted
Gene
Correlation
Network
Analysis
(WGCNA),
enrichment
analysis,
immune
infiltration
analysis
expression
characteristics
each
subtype,
while
also
filtering
genes
with
differential
between
subtypes.
Additionally,
through
COX
survival
identify
related
establish
a
nomogram.
Finally,
validate
CYP1B1
vivo
vitro
clinical
culture,
establishment
model.
Results
Three
subtypes
were
identified,
exhibiting
different
characteristics,
biological
pathways,
infiltration.
The
abundance
activated
NK
cells,
memory
B
M2
macrophages
showed
significant
differences
among
three
We
screened
four
sets
five
(CYP1B1,
EQTN,
NRXN2,
TBC1D3E,
TCEAL5)
Through
we
identified
33
independent
prognostic
constructed
nomogram,
calibration
curves
indicating
good
consistency.
selected
experimental
validation,
experiments
demonstrated
that
highly
participates
resistance
promotes
invasion,
migration,
tumor
progression
cells.
Conclusion
patterns
based
on
vary,
providing
theoretical
support
future
personalized
treatment
Язык: Английский
Anoikis Resistance in Cancer: Mechanisms, Therapeutic Strategies, Potential Targets, and Models for Enhanced Understanding
Cancer Letters,
Год журнала:
2025,
Номер
unknown, С. 217750 - 217750
Опубликована: Апрель 1, 2025
Язык: Английский
CircPIK3C2A dynamically orchestrates autophagy and apoptosis to enhance antibacterial immunity in yellow catfish (Pelteobagrus fulvidraco)
Aquaculture,
Год журнала:
2025,
Номер
unknown, С. 742753 - 742753
Опубликована: Май 1, 2025
Язык: Английский
Liquid-liquid phase separation of DDX3X: mechanisms, pathological implications, and therapeutic potential
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
317, С. 144835 - 144835
Опубликована: Май 31, 2025
Язык: Английский
New Relevant Evidence in Cholangiocarcinoma Biology and Characterization
Cancers,
Год журнала:
2024,
Номер
16(24), С. 4239 - 4239
Опубликована: Дек. 19, 2024
Among
solid
tumors,
cholangiocarcinoma
(CCA)
emerges
as
one
of
the
most
difficult
to
eradicate.
The
silent
and
asymptomatic
nature
this
tumor,
particularly
in
its
early
stages,
well
high
heterogeneity
at
genomic,
epigenetic,
molecular
levels
delay
diagnosis,
significantly
compromising
efficacy
current
therapeutic
options
thus
contributing
a
dismal
prognosis.
Extensive
research
has
been
conducted
on
pathobiology
CCA,
recent
advances
have
made
classification
characterization
new
targets.
Both
targeted
therapy
immunotherapy
emerged
effective
safe
strategies
for
various
types
cancers,
demonstrating
potential
benefits
advanced
CCA.
Furthermore,
deeper
comprehension
cellular
components
tumor
microenvironment
(TME)
opened
up
possibilities
innovative
treatment
methods.
This
review
discusses
evidence
biology
highlighting
novel
possible
druggable
Язык: Английский