Evaluating the Potential of Quantitative Susceptibility Mapping for Detecting Iron Deposition of Renal Fibrosis in a Rabbit Model

Journal of Magnetic Resonance Imaging, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Background As ferroptosis is a key factor in renal fibrosis (RF), iron deposition monitoring may help evaluating RF. The capability of quantitative susceptibility mapping (QSM) for detecting RF remains uncertain. Purpose To investigate the potential QSM to detect Study Type Animal model. Model Eighty New Zealand rabbits were randomly divided into control (N = 10) and 70) groups, consisting baseline, 7, 14, 21, 28 days 12 each), longitudinal subgroups. was induced via unilateral arteria stenosis. Field Strength/Sequence 3 T, with gradient echo, arterial spin labeling echo. Assessment Bilateral kidney values ( χ ) cortex CO outer medulla OM evaluated histopathology. Statistical Tests Analysis variance, Kruskal–Wallis, Spearman's correlation, area under receiver operating characteristic curve (AUC). P < 0.05 significant. Results In fibrotic kidneys, decreased at 7 ([−6.69 ± 0.98] × 10 −2 ppm) increased during 14–28 ([−1.85 2.11], [0.14 0.58], [1.99 0.60] ppm, respectively), while had opposite trend. Both significantly correlated histopathology (| r | 0.674–0.849). AUC distinguishing degrees 0.692–0.993. contralateral initially ([−6.67 0.84] then recovered baseline ([−4.81 0.89] ppm), 7–28 ([2.58 1.40], [2.25 1.83], [2.49 [2.43 1.32] respectively) higher than ([0.54 0.18] ppm). Data Conclusion Different patterns observed values, suggesting Plain Language Summary Renal (RF) common outcome most diseases, leading scarring loss function. Increasing evidence suggests that abnormal metabolism plays an important role This study used technique called measure levels Specifically, advanced exhibited concentrations, moderate strong correlations between demonstrated could accurately changes assess severity. Overall, shows promise as tool progression. Evidence Level 2 Technical Efficacy Stage

Язык: Английский

TGF-β1 induces ROS to activate ferroptosis via the ERK1/2-WISP1 pathway to promote the progression of renal tubular epithelial cell fibrosis

Cytotechnology, Год журнала: 2025, Номер 77(2)

Опубликована: Фев. 14, 2025

Язык: Английский

F-box only protein 10 protects against kidney tubulointerstitial fibrosis by inhibiting ACSL4-mediated lipid peroxidation and ferroptosis

Cellular Signalling, Год журнала: 2025, Номер unknown, С. 111841 - 111841

Опубликована: Апрель 1, 2025

Язык: Английский