Pan-cancer association of a mitochondrial function score with genomic alterations and clinical outcome DOI Creative Commons

Shikun Zhu,

Chen Chen, Min Wang

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Дек. 28, 2024

Mitochondria are pivotal in cellular energy metabolism and have garnered significant attention for their roles cancer progression therapy resistance. Despite this, the functional diversity of mitochondria across various types remains inadequately characterized. This study seeks to fill this knowledge gap by introducing validating MitoScore—a novel metric designed quantitatively assess mitochondrial function a wide array cancers. Our investigation evaluates capacity MitoScore not only distinguish between tumor adjacent normal tissues but also serve as predictive marker clinical outcomes. We analyzed gene expression data from 24 corresponding using TCGA database. was calculated summing normalized levels six genes known be consistently altered multiple Differential assessed DESeq2, with focus on identifying changes function. MitoScore's associations proliferation, hypoxia, aneuploidy, outcomes were evaluated Spearman's correlation, linear regression, Kaplan–Meier survival analyses. significantly higher compared most (p < 0.001). It positively correlated proliferation rates (r = 0.46), hypoxia scores 0.61), aneuploidy 0.44), indicating its potential aggressive behavior. High associated poorer prognosis several types, suggesting utility biomarker introduces MitoScore, activity often elevated tumors linked poor prognosis. correlates negatively stromal immune infiltration, highlighting mitochondria's role microenvironment. association genomic instability, such suggests dysfunction contributes progression. challenges mitochondrial-targeted therapies, may identify responsive treatments, warranting further research application.

Язык: Английский

Antioxidant-Rich Functional Foods and Exercise: Unlocking Metabolic Health Through Nrf2 and Related Pathways DOI Open Access
Halyna Tkachenko, Natalia Kurhaluk

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1098 - 1098

Опубликована: Янв. 27, 2025

This article reviews the synergistic effects of antioxidant-enriched functional foods and exercise in improving metabolic health, focusing on underlying molecular mechanisms. The review incorporates evidence from PubMed, SCOPUS, Web Science, PsycINFO, reference lists relevant up to 20 December 2024, highlighting central role Nrf2 pathway. As a critical regulator oxidative stress adaptation, mediates benefits these interventions. presents an innovative approach understanding regulation inflammation, its potential prevention treatment various diseases, including cancer, neurodegenerative disorders, cardiovascular pulmonary diabetes, inflammatory conditions, ageing, infections such as COVID-19. novelty this study is investigate bioactive compounds found (such polyphenols, flavonoids, vitamins) exercise-induced activation combined reveals their improve insulin sensitivity lipid metabolism reduce offering promising strategy for management chronic diseases. However, there are significant gaps current research, particularly regarding mechanisms interaction between diet, physical activity, activation, well long-term different populations, those with In addition, interactions other signalling pathways, AMPK, NF-κB, PI3K/Akt, collective contributions health explored. Furthermore, novel biomarkers presented assess impact strategies, NAD+/NADH ratio, GSH markers mitochondrial health. findings provide valuable insights into how integration antioxidant-rich diet regular can by activating related pathways represent strategies disorders. Further studies needed fully understand therapeutic interventions diseases stress, disease, cancer.

Язык: Английский

Процитировано

1
Cancer nanomedicine: Smart arsenal in the war against cancer DOI
Muneeb Ullah, Uzma Azeem Awan, Abdul Muhaymin

и другие.

Inorganic Chemistry Communications, Год журнала: 2025, Номер unknown, С. 114030 - 114030

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Mitochondrial alterations and signatures in hepatocellular carcinoma DOI Creative Commons
Tsung‐Hsien Chen, Shu-Hsien Lin, Ming‐Yang Lee

и другие.

Cancer and Metastasis Reviews, Год журнала: 2025, Номер 44(1)

Опубликована: Фев. 18, 2025

Язык: Английский

Процитировано

0
Molecular Insights in the Anticancer Activity of Natural Tocotrienols: Targeting Mitochondrial Metabolism and Cellular Redox Homeostasis DOI Creative Commons
Raffaella Chiaramonte,

Giulia Sauro,

Domenica Giannandrea

и другие.

Antioxidants, Год журнала: 2025, Номер 14(1), С. 115 - 115

Опубликована: Янв. 20, 2025

The role of mitochondria as the electric engine cells is well established. Over past two decades, accumulating evidence has pointed out that, despite presence a highly active glycolytic pathway (Warburg effect), functional and even upregulated mitochondrial respiration occurs in cancer to meet need high energy biosynthetic demand sustain their anabolic growth. Mitochondria are also primary source intracellular ROS. Cancer maintain moderate levels ROS promote tumorigenesis, metastasis, drug resistance; indeed, once cytotoxicity threshold exceeded, trigger oxidative damage, ultimately leading cell death. Based on this, metabolic functions generation considered attractive targets synthetic natural anticancer compounds. Tocotrienols (TTs), specifically δ- γ-TT isoforms, vitamin E-derived biomolecules widely shown possess striking properties since they regulate several molecular pathways. Herein, we provide for first time an overview reprogramming redox homeostasis perturbation occurring cells, highlighting involvement TTs. This sheds light use these compounds promising preventive or therapeutic approach novel strategies.

Язык: Английский

Процитировано

0
Emerging Role of Hypoxia-Inducible Factors (HIFs) in Modulating Autophagy: Perspectives on Cancer Therapy DOI Open Access
Maroua Jalouli

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1752 - 1752

Опубликована: Фев. 19, 2025

Hypoxia-inducible factors (HIFs) are master regulators of cellular responses to low oxygen levels and modulate autophagy, a conserved process essential for maintaining homeostasis. Under hypoxic conditions, HIFs regulate the expression autophagy-related genes influence autophagic flux stress responses. Dysregulated hypoxia-induced autophagy promotes cancer cell survival, metabolism, metastasis, thereby contributing treatment resistance. Targeting HIF-mediated pathways or modulating processes offers potential improve traditional therapies overcome drug Pharmacological inhibitors either alone in combination with other treatments, may disrupt pro-survival mechanisms within tumor microenvironment. Further research is needed elucidate intricate interplay between HIF signaling machinery cells. Understanding these could pave way novel therapeutic strategies enhance outcomes combat This review highlights complex relationship development therapy, offering insights into how targeting patient outcomes.

Язык: Английский

Процитировано

0
Epigenetic and Mitochondrial Metabolic Dysfunction in Multiple Sclerosis: A Review of Herbal Drug Approaches and Current Clinical Trials DOI Creative Commons

Ashwani,

Anjali Sharma,

Mayank Kumar Choudhary

и другие.

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Язык: Английский

Процитировано

0
Mitochondrial Dynamics Regulators in Cancer Metabolism and Progression DOI Creative Commons
Ahmed Shaaban,

Al-Hassan Soliman Wadan,

Mohamed El‐Sadek

и другие.

Mitochondrial Communications, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Pan-cancer association of a mitochondrial function score with genomic alterations and clinical outcome DOI Creative Commons

Shikun Zhu,

Chen Chen, Min Wang

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Дек. 28, 2024

Mitochondria are pivotal in cellular energy metabolism and have garnered significant attention for their roles cancer progression therapy resistance. Despite this, the functional diversity of mitochondria across various types remains inadequately characterized. This study seeks to fill this knowledge gap by introducing validating MitoScore—a novel metric designed quantitatively assess mitochondrial function a wide array cancers. Our investigation evaluates capacity MitoScore not only distinguish between tumor adjacent normal tissues but also serve as predictive marker clinical outcomes. We analyzed gene expression data from 24 corresponding using TCGA database. was calculated summing normalized levels six genes known be consistently altered multiple Differential assessed DESeq2, with focus on identifying changes function. MitoScore's associations proliferation, hypoxia, aneuploidy, outcomes were evaluated Spearman's correlation, linear regression, Kaplan–Meier survival analyses. significantly higher compared most (p < 0.001). It positively correlated proliferation rates (r = 0.46), hypoxia scores 0.61), aneuploidy 0.44), indicating its potential aggressive behavior. High associated poorer prognosis several types, suggesting utility biomarker introduces MitoScore, activity often elevated tumors linked poor prognosis. correlates negatively stromal immune infiltration, highlighting mitochondria's role microenvironment. association genomic instability, such suggests dysfunction contributes progression. challenges mitochondrial-targeted therapies, may identify responsive treatments, warranting further research application.

Язык: Английский

Процитировано

1