Post-Translational Modifications of Proteins Orchestrate All Hallmarks of Cancer
Life,
Год журнала:
2025,
Номер
15(1), С. 126 - 126
Опубликована: Янв. 18, 2025
Post-translational
modifications
(PTMs)
of
proteins
dynamically
build
the
buffering
and
adapting
interface
between
oncogenic
mutations
environmental
stressors,
on
one
hand,
cancer
cell
structure,
functioning,
behavior.
Aberrant
PTMs
can
be
considered
as
enabling
characteristics
long
they
orchestrate
all
malignant
variability
in
proteome
cells,
cancer-associated
tumor
microenvironment
(TME).
On
other
enhance
anticancer
mechanisms
tumoral
ecosystem
or
sustain
beneficial
effects
oncologic
therapies
through
degradation
inactivation
carcinogenic
or/and
activation
tumor-suppressor
proteins.
In
this
review,
we
summarized
analyzed
a
wide
spectrum
involved
regulatory
that
drive
tumorigenesis,
genetic
instability,
epigenetic
reprogramming,
events
metastatic
cascade,
cytoskeleton
extracellular
matrix
(ECM)
remodeling,
angiogenesis,
immune
response,
tumor-associated
microbiome,
metabolism
rewiring
most
important
hallmarks
cancer.
All
develop
due
to
proteins,
which
modulate
gene
transcription,
intracellular
signaling,
protein
size,
activity,
stability
localization,
trafficking,
secretion,
half-life,
protein–protein
interactions
(PPIs).
associated
with
exploited
better
understand
underlying
molecular
heterogeneous
chameleonic
disease,
find
new
biomarkers
progression
prognosis,
personalize
oncotherapies,
discover
targets
for
drug
development.
Язык: Английский
Triple-Negative Breast Cancer Progression and Drug Resistance in the Context of Epithelial–Mesenchymal Transition
Cancers,
Год журнала:
2025,
Номер
17(2), С. 228 - 228
Опубликована: Янв. 12, 2025
Triple-negative
breast
cancer
(TNBC)
is
one
of
the
most
difficult
subtypes
to
treat
due
its
distinct
clinical
and
molecular
characteristics.
Patients
with
TNBC
face
a
high
recurrence
rate,
an
increased
risk
metastasis,
lower
overall
survival
compared
other
subtypes.
Despite
advancements
in
targeted
therapies,
traditional
chemotherapy
(primarily
using
platinum
compounds
taxanes)
continues
be
standard
treatment
for
TNBC,
often
limited
long-term
efficacy.
tumors
are
heterogeneous,
displaying
diverse
mutation
profile
considerable
chromosomal
instability,
which
complicates
therapeutic
interventions.
The
development
chemoresistance
frequently
associated
process
epithelial–mesenchymal
transition
(EMT),
during
epithelial
tumor
cells
acquire
mesenchymal-like
phenotype.
This
shift
enhances
metastatic
potential,
while
simultaneously
reducing
effectiveness
chemotherapeutics.
It
has
also
been
suggested
that
EMT
plays
central
role
stem
cells.
Hence,
there
growing
interest
exploring
small-molecule
inhibitors
target
as
future
strategy
overcoming
resistance
improving
outcomes
patients
TNBC.
review
focuses
on
progression
drug
emphasis
these
processes.
We
present
TNBC-specific
EMT-related
features,
key
protein
markers,
various
signaling
pathways
involved.
discuss
important
mechanisms
factors
related
within
context
EMT,
highlighting
improve
patients’
outcomes.
Язык: Английский
Roles of Post-Translational Modifications of Transcription Factors Involved in Breast Cancer Hypoxia
Logan Seymour,
Niyogushima Nuru,
Kaya R. Johnson
и другие.
Molecules,
Год журнала:
2025,
Номер
30(3), С. 645 - 645
Опубликована: Фев. 1, 2025
BC
is
the
most
commonly
diagnosed
cancer
and
second
leading
cause
of
death
among
women
worldwide.
Cellular
stress
a
condition
that
leads
to
disrupted
homeostasis
by
extrinsic
intrinsic
factors.
Among
other
stressors,
hypoxia
driving
force
for
breast
(BC)
progression
general
hallmark
solid
tumors.
Thus,
intratumoral
an
important
determinant
invasion,
metastasis,
treatment
failure,
prognosis,
patient
mortality.
Acquisition
epithelial–mesenchymal
transition
(EMT)
phenotype
also
consequence
tumor
hypoxia.
The
cellular
response
mainly
regulated
signaling
pathway,
governed
hypoxia-inducible
factors
(HIFs),
HIF1α.
HIFs
are
family
transcription
(TFs),
which
induce
expression
target
genes
involved
in
cell
survival
proliferation,
metabolic
reprogramming,
angiogenesis,
resisting
apoptosis,
metastasis.
HIF1α
cooperates
with
large
number
TFs.
In
this
review,
we
focused
on
crosstalk
cooperation
between
TFs
BC.
We
identified
cluster
TFs,
proposed
as
HIF1α-TF
interactome,
orchestrates
hypoxia,
due
their
post-translational
modifications
(PTMs),
including
phosphorylation/dephosphorylation,
ubiquitination/deubiquitination,
SUMOylation,
hydroxylation,
acetylation,
S-nitrosylation,
palmitoylation.
PTMs
these
HIF1α-related
drive
stability
activity,
degradation
turnover,
bidirectional
translocation
cytoplasm
or
plasma
membrane
nucleus
cells,
well
transcription/activation
proteins
encoded
oncogenes
inactivation
suppressor
genes.
Consequently,
interactome
crucial
regulatory
mechanisms
oxygen
deprivation
cells.
Язык: Английский
Study on the Effect of Deer Bone in Improving Rheumatoid Arthritis Based on the “Drug-Target-Pathway” Association Network
Journal of Ethnopharmacology,
Год журнала:
2025,
Номер
unknown, С. 119684 - 119684
Опубликована: Март 1, 2025
Язык: Английский
Antitumor effects of dauricine on sorafenib-treated human lung cancer cell lines via modulation of HIF-1α signaling pathways
Medical Oncology,
Год журнала:
2025,
Номер
42(5)
Опубликована: Апрель 9, 2025
Язык: Английский
The Regulation of Trace Metal Elements in Cancer Ferroptosis
Advanced Biology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 9, 2025
Abstract
Ferroptosis,
as
novel
type
of
regulated
cell
death
that
has
garnered
widespread
attention
over
the
past
decade,
witnessed
continuous
discovery
an
increasing
number
regulatory
mechanisms.
Trace
metal
elements
play
a
multifaceted
and
crucial
role
in
oncology.
Interestingly,
it
been
increasingly
evident
these
elements,
such
copper,
are
involved
regulation
iron
accumulation,
lipid
peroxidation
antiferroptotic
systems,
suggesting
existence
“nonferrous”
mechanisms
ferroptosis.
In
this
review,
comprehensive
overview
composition
mechanism
ferroptosis
is
provided.
The
interaction
between
copper
metabolism
(including
cuproptosis)
cancer,
well
roles
other
trace
(such
zinc,
manganese,
cobalt,
molybdenum)
specifically
focused.
Furthermore,
applications
nanomaterials
based
on
metals
cancer
therapy
also
reviewed
potential
strategies
for
co‐targeting
cuproptosis
explored.
Nevertheless,
light
intricate
ambiguous
nature
interactions,
ongoing
research
essential
to
further
elucidate
ferroptosis,
thereby
facilitating
development
therapeutic
targets
approaches
treatment.
Язык: Английский
FTO-Mediated m6A Demethylation of OTUB1 Stabilizes SLC7A11 to Alleviate Ferroptosis in Cerebral Ischemia/Reperfusion Injury
Journal of Stroke and Cerebrovascular Diseases,
Год журнала:
2025,
Номер
unknown, С. 108316 - 108316
Опубликована: Апрель 1, 2025
Язык: Английский
Nanomedicine for cancer patient‐centered care
MedComm,
Год журнала:
2024,
Номер
5(11)
Опубликована: Окт. 20, 2024
Abstract
Cancer
is
a
leading
cause
of
morbidity
and
mortality
worldwide,
an
increase
in
incidence
estimated
the
next
future,
due
to
population
aging,
which
requires
development
highly
tolerable
low‐toxicity
cancer
treatment
strategies.
The
use
nanotechnology
tailor
treatments
according
genetic
immunophenotypic
characteristics
patient's
tumor,
allow
its
targeted
release,
can
meet
this
need,
improving
efficacy
minimizing
side
effects.
Nanomedicine‐based
approach
for
diagnosis
rapidly
evolving
field.
Several
nanoformulations
are
currently
clinical
trials,
some
have
been
approved
marketed.
However,
their
large‐scale
production
still
hindered
by
in‐depth
debate
involving
ethics,
intellectual
property,
safety
health
concerns,
technical
issues,
costs.
Here,
we
survey
key
approaches,
with
specific
reference
organ‐on
chip
technology,
cutting‐edge
tools,
such
as
CRISPR/Cas9
genome
editing,
through
nanosystems
needs
personalized
diagnostics
therapy
patients.
An
update
provided
on
nanopharmaceuticals
marketed
those
undergoing
trials.
Finally,
discuss
emerging
avenues
field
challenges
be
overcome
transfer
nano‐based
precision
oncology
into
daily
life.
Язык: Английский