Reactive Oxygen Species in Plants: Metabolism, Signaling, and Oxidative Modifications DOI Creative Commons
Chao Zheng, Jianping Chen, Xiao‐Wei Wang

и другие.

Antioxidants, Год журнала: 2025, Номер 14(6), С. 617 - 617

Опубликована: Май 22, 2025

Reactive oxygen species (ROS) serve as crucial signaling molecules that facilitate the interactions between plants and environmental stimuli, thereby influencing a wide range of physiological biochemical processes, such vegetative apex development organ morphogenesis. In response to stresses, enhance ROS production initiate robust protective response. To manage excessive levels, have developed sophisticated antioxidative defense system comprising both enzymatic non-enzymatic components, which work synergistically scavenge alleviate ROS-induced deleterious effects on biomolecules. This review provides comprehensive overview metabolism, transduction pathways, their implications for oxidative modification nucleic acids, lipids, proteins within plant cells.

Язык: Английский

Crosstalk between metabolism and epigenetics during macrophage polarization DOI Creative Commons
Kangling Zhang, Chinnaswamy Jagannath

Epigenetics & Chromatin, Год журнала: 2025, Номер 18(1)

Опубликована: Март 29, 2025

Macrophage polarization is a dynamic process driven by complex interplay of cytokine signaling, metabolism, and epigenetic modifications mediated pathogens. Upon encountering specific environmental cues, monocytes differentiate into macrophages, adopting either pro-inflammatory (M1) or anti-inflammatory (M2) phenotype, depending on the cytokines present. M1 macrophages are induced interferon-gamma (IFN-γ) characterized their reliance glycolysis role in host defense. In contrast, M2 stimulated interleukin-4 (IL-4) interleukin-13 (IL-13), favor oxidative phosphorylation participate tissue repair responses. Metabolism tightly linked to regulation, because key metabolic intermediates such as acetyl-coenzyme A (CoA), α-ketoglutarate (α-KG), S-adenosylmethionine (SAM), nicotinamide adenine dinucleotide (NAD+) serve cofactors for chromatin-modifying enzymes, which turn, directly influences histone acetylation, methylation, RNA/DNA protein arginine methylation. These control gene expression regulating chromatin accessibility, thereby modulating macrophage function polarization. Histone acetylation generally promotes more open structure conducive activation, while methylation can activate repress residue its state. Crosstalk between modifications, further fine-tunes phenotypes transcriptional networks response cues. While primarily functions epigenetics through degradation methylated proteins releases derivatives like asymmetric dimethylarginine (ADMA), contribute metabolism-a factor This review explores intricate relationships metabolism regulation during better understanding this crosstalk will likely generate novel therapeutic insights manipulating infections tuberculosis inflammatory diseases diabetes.

Язык: Английский

Процитировано

5
Epigenetic Modifications as Novel Therapeutic Strategies of Cancer Chemoprevention by Phytochemicals DOI

Hui-Hsia Hsieh,

M. Kuo,

I-An Chen

и другие.

Pharmaceutical Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 7, 2025

Язык: Английский

Процитировано

0
Oxidative stress and central metabolism pathways impact epigenetic modulation in inflammation and immune response DOI
Jose Luis García‐Giménez, Irene Cánovas-Cervera, Elena Nácher-Sendra

и другие.

Free Radical Biology and Medicine, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Reactive Oxygen Species in Plants: Metabolism, Signaling, and Oxidative Modifications DOI Creative Commons
Chao Zheng, Jianping Chen, Xiao‐Wei Wang

и другие.

Antioxidants, Год журнала: 2025, Номер 14(6), С. 617 - 617

Опубликована: Май 22, 2025

Reactive oxygen species (ROS) serve as crucial signaling molecules that facilitate the interactions between plants and environmental stimuli, thereby influencing a wide range of physiological biochemical processes, such vegetative apex development organ morphogenesis. In response to stresses, enhance ROS production initiate robust protective response. To manage excessive levels, have developed sophisticated antioxidative defense system comprising both enzymatic non-enzymatic components, which work synergistically scavenge alleviate ROS-induced deleterious effects on biomolecules. This review provides comprehensive overview metabolism, transduction pathways, their implications for oxidative modification nucleic acids, lipids, proteins within plant cells.

Язык: Английский

Процитировано

0