Crosstalk Between Autophagy and Oxidative Stress in Hematological Malignancies: Mechanisms, Implications, and Therapeutic Potential DOI Creative Commons
Antonio José Cabrera-Serrano, José Manuel Sánchez‐Maldonado, Carmen González‐Olmedo

и другие.

Antioxidants, Год журнала: 2025, Номер 14(3), С. 264 - 264

Опубликована: Фев. 25, 2025

Autophagy is a fundamental cellular process that maintains homeostasis by degrading damaged components and regulating stress responses. It plays crucial role in cancer biology, including tumor progression, metastasis, therapeutic resistance. Oxidative stress, similarly, key to maintaining balance oxidants antioxidants, with its disruption leading molecular damage. The interplay between autophagy oxidative particularly significant, as reactive oxygen species (ROS) act both inducers by-products of autophagy. While can function suppressor early stages, it often shifts pro-tumorigenic advanced disease, aiding cell survival under adverse conditions such hypoxia nutrient deprivation. This dual mediated several signaling pathways, PI3K/AKT/mTOR, AMPK, HIF-1α, which coordinate the autophagic activity ROS production. In this review, we explore mechanisms interact across different hematological malignancies. We discuss how triggers autophagy, creating feedback loop promotes survival, dysregulation leads increased accumulation, exacerbating tumorigenesis. also examine implications targeting autophagy-oxidative axis cancer. Current strategies involve modulating through specific inhibitors, enhancing levels pro-oxidant compounds, combining these approaches conventional therapies overcome drug Understanding complex relationship provides critical insights into novel aimed at improving treatment outcomes.

Язык: Английский

Crosstalk Between Autophagy and Oxidative Stress in Hematological Malignancies: Mechanisms, Implications, and Therapeutic Potential DOI Creative Commons
Antonio José Cabrera-Serrano, José Manuel Sánchez‐Maldonado, Carmen González‐Olmedo

и другие.

Antioxidants, Год журнала: 2025, Номер 14(3), С. 264 - 264

Опубликована: Фев. 25, 2025

Autophagy is a fundamental cellular process that maintains homeostasis by degrading damaged components and regulating stress responses. It plays crucial role in cancer biology, including tumor progression, metastasis, therapeutic resistance. Oxidative stress, similarly, key to maintaining balance oxidants antioxidants, with its disruption leading molecular damage. The interplay between autophagy oxidative particularly significant, as reactive oxygen species (ROS) act both inducers by-products of autophagy. While can function suppressor early stages, it often shifts pro-tumorigenic advanced disease, aiding cell survival under adverse conditions such hypoxia nutrient deprivation. This dual mediated several signaling pathways, PI3K/AKT/mTOR, AMPK, HIF-1α, which coordinate the autophagic activity ROS production. In this review, we explore mechanisms interact across different hematological malignancies. We discuss how triggers autophagy, creating feedback loop promotes survival, dysregulation leads increased accumulation, exacerbating tumorigenesis. also examine implications targeting autophagy-oxidative axis cancer. Current strategies involve modulating through specific inhibitors, enhancing levels pro-oxidant compounds, combining these approaches conventional therapies overcome drug Understanding complex relationship provides critical insights into novel aimed at improving treatment outcomes.

Язык: Английский

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