Genes & Development,
Год журнала:
2020,
Номер
34(5-6), С. 302 - 320
Опубликована: Фев. 6, 2020
ADP-ribosylation
(ADPRylation)
is
a
posttranslational
modification
of
proteins
discovered
nearly
six
decades
ago,
but
many
important
questions
remain
regarding
its
molecular
functions
and
biological
roles,
as
well
the
activity
ADP-ribose
(ADPR)
transferase
enzymes
(PARP
family
members)
that
catalyze
it.
Growing
evidence
indicates
PARP-mediated
ADPRylation
events
are
key
regulators
protein
biosynthetic
pathway,
leading
from
rDNA
transcription
ribosome
biogenesis
to
mRNA
synthesis,
processing,
translation.
In
this
review
we
describe
role
PARP
in
all
facets
pathway.
PARP-1
enzymatic
transcription,
which
critical
step
biogenesis.
An
emerging
PARPs
alternative
splicing
mRNAs,
direct
highlight
members
RNA
processing.
Furthermore,
activity,
stimulated
by
cellular
stresses,
such
viral
infections
ER
stress,
leads
regulation
stability
synthesis
through
posttranscriptional
mechanisms.
Dysregulation
these
processes
can
promote
disease
states.
Collectively,
results
importance
gene
regulation,
abundance.
Future
studies
areas
will
yield
new
insights
into
fundamental
mechanisms
broader
utility
for
PARP-targeted
therapeutic
agents.
Natural Products and Bioprospecting,
Год журнала:
2022,
Номер
12(1)
Опубликована: Май 9, 2022
Abstract
Human
longevity
has
increased
dramatically
during
the
past
century.
More
than
20%
of
9
billion
population
world
will
exceed
age
60
in
2050.
Since
last
three
decades,
some
interventions
and
many
preclinical
studies
have
been
found
to
show
slowing
aging
increasing
healthy
lifespan
organisms
from
yeast,
flies,
rodents
nonhuman
primates.
The
are
classified
into
two
groups:
lifestyle
modifications
pharmacological/genetic
manipulations.
Some
genetic
pathways
characterized
a
specific
role
controlling
lifespan.
Thus,
all
genes
potential
antiaging
targets.
Currently,
compounds
target
calorie-restriction
mimetic,
autophagy
induction,
putative
enhancement
cell
regeneration,
epigenetic
modulation
gene
activity
such
as
inhibition
histone
deacetylases
DNA
methyltransferases,
under
development.
It
appears
evident
that
exploration
new
targets
for
these
agents
based
on
biogerontological
research
provides
an
incredible
opportunity
healthcare
pharmaceutical
industries.
present
review
focus
properties
slow
life
span
extension
natural
products
various
biological
resources,
endogenous
substances,
drugs,
synthetic
compounds,
well
mechanisms
evaluation.
These
bioactive
could
benefit
discussed.
Trends in Cell Biology,
Год журнала:
2023,
Номер
33(9), С. 788 - 802
Опубликована: Март 5, 2023
Autophagy
is
an
intracellular
degradation
pathway
that
recycles
subcellular
components
to
maintain
metabolic
homeostasis.
NAD
essential
metabolite
participates
in
energy
metabolism
and
serves
as
a
substrate
for
series
of
NAD+-consuming
enzymes
(NADases),
including
PARPs
SIRTs.
Declining
levels
autophagic
activity
represent
features
cellular
ageing,
consequently
enhancing
either
significantly
extends
health/lifespan
animals
normalises
cells.
Mechanistically,
it
has
been
shown
NADases
can
directly
regulate
autophagy
mitochondrial
quality
control.
Conversely,
preserve
by
modulating
stress.
In
this
review
we
highlight
the
mechanisms
underlying
bidirectional
relationship
between
autophagy,
potential
therapeutic
targets
provides
combatting
age-related
disease
promoting
longevity.
Translational Neurodegeneration,
Год журнала:
2023,
Номер
12(1)
Опубликована: Янв. 26, 2023
Alzheimer's
disease
(AD)
is
associated
with
metabolic
abnormalities
linked
to
critical
elements
of
neurodegeneration.
We
recently
administered
combined
activators
(CMA)
the
AD
rat
model
and
observed
that
CMA
improves
AD-associated
histological
parameters
in
animals.
promotes
mitochondrial
fatty
acid
uptake
from
cytosol,
facilitates
oxidation
mitochondria,
alleviates
oxidative
stress.
Military Medical Research,
Год журнала:
2024,
Номер
11(1)
Опубликована: Май 29, 2024
Abstract
Mitochondria,
the
most
crucial
energy-generating
organelles
in
eukaryotic
cells,
play
a
pivotal
role
regulating
energy
metabolism.
However,
their
significance
extends
beyond
this,
as
they
are
also
indispensable
vital
life
processes
such
cell
proliferation,
differentiation,
immune
responses,
and
redox
balance.
In
response
to
various
physiological
signals
or
external
stimuli,
sophisticated
mitochondrial
quality
control
(MQC)
mechanism
has
evolved,
encompassing
key
like
biogenesis,
dynamics,
mitophagy,
which
have
garnered
increasing
attention
from
researchers
unveil
specific
molecular
mechanisms.
this
review,
we
present
comprehensive
summary
of
primary
mechanisms
functions
regulators
involved
major
components
MQC.
Furthermore,
critical
regulated
by
MQC
its
diverse
roles
progression
systemic
diseases
been
described
detail.
We
discuss
agonists
antagonists
targeting
MQC,
aiming
explore
potential
therapeutic
research
prospects
enhancing
stabilize
function.
Genes & Development,
Год журнала:
2020,
Номер
34(5-6), С. 302 - 320
Опубликована: Фев. 6, 2020
ADP-ribosylation
(ADPRylation)
is
a
posttranslational
modification
of
proteins
discovered
nearly
six
decades
ago,
but
many
important
questions
remain
regarding
its
molecular
functions
and
biological
roles,
as
well
the
activity
ADP-ribose
(ADPR)
transferase
enzymes
(PARP
family
members)
that
catalyze
it.
Growing
evidence
indicates
PARP-mediated
ADPRylation
events
are
key
regulators
protein
biosynthetic
pathway,
leading
from
rDNA
transcription
ribosome
biogenesis
to
mRNA
synthesis,
processing,
translation.
In
this
review
we
describe
role
PARP
in
all
facets
pathway.
PARP-1
enzymatic
transcription,
which
critical
step
biogenesis.
An
emerging
PARPs
alternative
splicing
mRNAs,
direct
highlight
members
RNA
processing.
Furthermore,
activity,
stimulated
by
cellular
stresses,
such
viral
infections
ER
stress,
leads
regulation
stability
synthesis
through
posttranscriptional
mechanisms.
Dysregulation
these
processes
can
promote
disease
states.
Collectively,
results
importance
gene
regulation,
abundance.
Future
studies
areas
will
yield
new
insights
into
fundamental
mechanisms
broader
utility
for
PARP-targeted
therapeutic
agents.
