Cell Death Discovery,
Год журнала:
2025,
Номер
11(1)
Опубликована: Апрель 9, 2025
Abstract
The
complex
interplay
between
cancer
progression
and
immune
senescence
is
critically
influenced
by
metabolic
reprogramming
in
T
cells.
As
cells
age,
especially
within
the
tumor
microenvironment,
they
undergo
significant
shifts
that
may
hinder
their
proliferation
functionality.
This
manuscript
reviews
how
alterations
contribute
to
cell
discusses
potential
therapeutic
strategies
aimed
at
reversing
these
changes.
We
explore
interventions
such
as
mitochondrial
enhancement,
glycolytic
inhibition,
lipid
metabolism
adjustments
could
rejuvenate
senescent
cells,
potentially
restoring
efficacy
suppression.
review
also
focuses
on
significance
of
with
aging
further
explores
future
direction
metabolism-based
immunotherapy
Molecular Cell,
Год журнала:
2023,
Номер
83(19), С. 3404 - 3420
Опубликована: Окт. 1, 2023
Mitochondria
are
central
hubs
of
cellular
metabolism
that
also
play
key
roles
in
signaling
and
disease.
It
is
therefore
fundamentally
important
mitochondrial
quality
activity
tightly
regulated.
Mitochondrial
degradation
pathways
contribute
to
control
networks
can
regulate
the
metabolic
profile
mitochondria
ensure
homeostasis.
Here,
we
cover
many
varied
ways
which
cells
degrade
or
remove
their
unwanted
mitochondria,
ranging
from
mitophagy
extrusion.
The
molecular
signals
driving
these
discussed,
including
physiological
contexts
under
different
engaged.
Cancers,
Год журнала:
2022,
Номер
14(9), С. 2183 - 2183
Опубликована: Апрель 27, 2022
Sphingolipids
are
bioactive
molecules
that
have
key
roles
in
regulating
tumor
cell
death
and
survival
through,
part,
the
functional
of
ceramide
accumulation
sphingosine-1-phosphate
(S1P)
production,
respectively.
Mechanistic
studies
using
lines,
mouse
models,
or
human
tumors
revealed
crucial
sphingolipid
metabolic
signaling
progression
response
to
anticancer
therapy.
Specifically,
understand
S1P
production
pathways
with
their
downstream
targets
provided
novel
therapeutic
strategies
for
cancer
treatment.
In
this
review,
we
present
recent
evidence
critical
sphingolipids
enzymes
via
mechanisms
involving
survival.
The
enabling
growth/metastasis
conferring
resistance
existing
therapeutics
also
highlighted.
Additionally,
publicly
available
transcriptomic
database,
assess
prognostic
values
on
overall
patients
different
malignancies
highlight
clinical
implications
In
this
review,
we
discuss
in
detail
the
most
relevant
proteolytic
systems
that
together
with
chaperones
contribute
to
creating
proteostasis
network
is
kept
dynamic
balance
maintain
overall
functionality
of
cellular
proteomes.
Data
accumulated
over
decades
demonstrate
effectiveness
elements
declines
age.
scenario,
failure
degrade
misfolded
or
faulty
proteins
increases
risk
protein
aggregation,
chronic
inflammation,
and
development
age-related
diseases.
This
especially
important
context
aging-related
modification
functions
immune
system.
Frontiers in Immunology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 16, 2025
Biological
sex
is
closely
associated
with
the
properties
and
extent
of
immune
response,
males
females
showing
different
susceptibilities
to
diseases
variations
in
immunity.
Androgens,
predominantly
males,
generally
suppress
responses,
while
estrogens,
more
abundant
females,
tend
enhance
It
also
established
that
hormones
at
least
partially
explain
biases
diseases,
particularly
autoimmune
females.
These
differences
are
influenced
by
hormonal,
genetic,
environmental
factors,
vary
throughout
life
stages.
The
advent
gender-affirming
hormone
therapy
offers
a
novel
opportunity
study
immunological
effects
hormones.
Despite
limited
studies
on
this
topic,
available
research
has
revealed
testosterone
transgender
men
may
certain
functions,
such
as
type
I
interferon
increasing
inflammation
markers
like
TNF-α.
Transgender
women
estrogen
experience
alterations
coagulation-related
inflammatory
characteristics.
Furthermore,
other
possible
regulation
can
be
inferred
from
assessment
individuals
receiving
therapy.
Understanding
complex
interactions
between
system,
through
unique
perspective
offered
therapies,
facilitate
development
targeted
therapies
for
infections
improving
healthcare
outcomes
individuals.
Here
we
review
dynamics
both
sexes
provide
summary
findings
drawn
exploring
