Expert Opinion on Therapeutic Targets,
Год журнала:
2022,
Номер
26(3), С. 233 - 259
Опубликована: Март 4, 2022
Introduction
The
analysis
of
the
role
mitochondria
in
oxidative
damage
and
skin
aging
has
been
a
significant
aspect
dermatological
research.
Mitochondria
generate
most
reactive
oxygen
species
(ROS)
which,
excess,
are
cytotoxic
DNA-damaging
promote
(photo-)aging.
However,
ROS
also
possesses
key
physiological
regulatory
functions
mitochondrial
dysfunction
is
prominent
several
not
primarily
senescence-associated
diseases
cancers.
Although
many
standard
dermatotherapeutics
modulate
function,
therapy
rarely
targets
mitochondria.
Accordingly,
there
rationale
for
'mitochondrial
dermatology'-based
approaches
to
be
applied
therapeutic
research,
as
we
advocate
here.Areas
covered
This
paper
examines
cutaneous
physiology
beyond
energy
(ATP)
production.
Keratinocyte
differentiation
epidermal
barrier
maintenance,
appendage
morphogenesis
homeostasis,
photoaging
cancer
considered.
Based
on
related
PubMed
search
results,
evaluates
thyroid
hormones,
glucocorticoids,
Vitamin
D3
derivatives,
retinoids,
cannabinoid
receptor
agonists,
PPARγ
thyrotropin,
thyrotropin-releasing
hormone
instructive
lead
compounds.
Moreover,
protein
MPZL3
promising
new
drug
target
future
dermatology'
highlighted.Expert
opinion
Future
research
should
have
medicine
emphasis.
Focusing
selected
agents,
targets,
silico
design,
model
will
fertilize
mito-centric
approach.
Protein & Cell,
Год журнала:
2024,
Номер
15(9), С. 642 - 660
Опубликована: Фев. 29, 2024
Abstract
Cell
death
resistance
represents
a
hallmark
of
cancer.
Recent
studies
have
identified
metabolic
cell
as
unique
forms
regulated
resulting
from
an
imbalance
in
the
cellular
metabolism.
This
review
discusses
mechanisms
death—ferroptosis,
cuproptosis,
disulfidptosis,
lysozincrosis,
and
alkaliptosis—and
explores
their
potential
cancer
therapy.
Our
underscores
complexity
pathways
offers
insights
into
innovative
therapeutic
avenues
for
treatment.
Biomedicines,
Год журнала:
2022,
Номер
10(5), С. 1072 - 1072
Опубликована: Май 5, 2022
Metal
ion
homeostasis
is
fundamental
for
life.
Specifically,
transition
metals
iron,
manganese
and
zinc
play
a
pivotal
role
in
mitochondrial
metabolism
energy
generation,
anti-oxidation
defense,
transcriptional
regulation
the
immune
response.
The
misregulation
of
expression
or
mutations
carriers
corresponding
changes
Mn2+
Zn2+
levels
suggest
that
these
ions
cancer
progression.
Moreover,
coordinated
have
been
detected,
suggesting
particular
mechanisms
influenced
by
both
might
be
required
growth
cells,
metastasis
evasion.
Here,
we
present
review
pathophysiology
cooperatively
regulate
cancerogenesis.
Zn
Mn
effects
converge
on
mitochondria-induced
apoptosis,
cGAS-STING
signaling
pathway,
mediating
Both
influence
progression
impact
treatment
efficacy
animal
models
clinical
trials.
We
predict
novel
strategies
targeting
will
complement
current
therapeutic
strategies.
Physiological Reviews,
Год журнала:
2024,
Номер
104(3), С. 1335 - 1385
Опубликована: Март 7, 2024
The
endomembrane
system
consists
of
organellar
membranes
in
the
biosynthetic
pathway
[endoplasmic
reticulum
(ER),
Golgi
apparatus,
and
secretory
vesicles]
as
well
those
degradative
(early
endosomes,
macropinosomes,
phagosomes,
autophagosomes,
late
lysosomes).
These
organelles/vesicles
work
together
to
synthesize,
modify,
package,
transport,
degrade
proteins,
carbohydrates,
lipids,
regulating
balance
between
cellular
anabolism
catabolism.
Large
ion
concentration
gradients
exist
across
endomembranes:
Ca
2+
for
most
organelles
H
+
acidic
compartments.
Ion
(Na
,
K
Cl
−
)
channels
on
control
flux
response
cues,
allowing
rapid
informational
exchange
cytosol
organelle
lumen.
Recent
advances
proteomics,
electrophysiology,
luminal
juxtaorganellar
imaging
have
led
molecular
identification
functional
characterization
about
two
dozen
channels.
For
example,
whereas
IP3R1–3
mediate
release
from
ER
neurotransmitter
hormone
stimulation,
TRPML1–3
TMEM175
lysosomal
release,
respectively,
nutritional
trafficking
cues.
This
review
aims
summarize
current
understanding
these
channels,
with
a
focus
their
subcellular
localizations,
permeation
properties,
gating
mechanisms,
cell
biological
functions,
disease
relevance.
Cell Death and Disease,
Год журнала:
2024,
Номер
15(8)
Опубликована: Авг. 1, 2024
Abstract
Pancreatic
cancer
is
an
aggressive
with
a
poor
prognosis.
Metabolic
abnormalities
are
one
of
the
hallmarks
pancreatic
cancer,
and
cells
can
adapt
to
biosynthesis,
energy
intake,
redox
needs
through
metabolic
reprogramming
tolerate
nutrient
deficiency
hypoxic
microenvironments.
use
glucose,
amino
acids,
lipids
as
maintain
malignant
growth.
Moreover,
they
also
metabolically
interact
in
tumour
microenvironment
change
cell
fate,
promote
progression,
even
affect
immune
responses.
Importantly,
changes
at
body
level
deserve
more
attention.
Basic
research
clinical
trials
based
on
targeted
therapy
or
combination
other
treatments
full
swing.
A
comprehensive
in-depth
understanding
regulation
will
not
only
enrich
mechanisms
disease
progression
but
provide
inspiration
for
new
diagnostic
therapeutic
approaches.
Cell Death and Disease,
Год журнала:
2024,
Номер
15(4)
Опубликована: Апрель 27, 2024
Abstract
Mitochondria
are
the
centers
of
energy
and
material
metabolism,
they
also
serve
as
storage
dispatch
hubs
metal
ions.
Damage
to
mitochondrial
structure
function
can
cause
abnormal
levels
distribution
ions,
leading
cell
dysfunction
even
death.
For
a
long
time,
quality
control
pathways
such
dynamics
mitophagy
have
been
considered
inhibit
metal-induced
However,
with
discovery
new
metal-dependent
death
including
ferroptosis
cuproptosis,
increasing
evidence
shows
that
there
is
complex
relationship
between
This
article
reviews
latest
research
results
mechanisms
crosstalk
in
recent
years,
well
their
involvement
neurodegenerative
diseases,
tumors
other
order
provide
ideas
for
treatment
related
diseases.
Autophagy,
Год журнала:
2024,
Номер
20(8), С. 1712 - 1722
Опубликована: Март 24, 2024
MCOLN1/TRPML1
is
a
nonselective
cationic
channel
specifically
localized
to
the
late
endosome
and
lysosome.
With
its
property
of
mediating
release
several
divalent
cations
such
as
Ca2+,
Zn2+
Fe2+
from
lysosome
cytosol,
MCOLN1
plays
pivotal
role
in
regulating
variety
cellular
events
including
endocytosis,
exocytosis,
lysosomal
biogenesis,
reformation,
especially
Macroautophagy/autophagy.
Autophagy
highly
conserved
catabolic
process
that
maintains
cytoplasmic
integrity
by
removing
superfluous
proteins
damaged
organelles.
Acting
terminal
compartments,
lysosomes
are
crucial
for
completion
autophagy
process.
This
review
delves
into
emerging
controlling
autophagic
ionic
homeostasis,
thereby
governing
fundamental
functions
lysosomes.
Furthermore,
this
summarizes
physiological
relevance
well
molecular
mechanisms
through
which
orchestrates
autophagy,
consequently
influencing
mitochondria
turnover,
cell
apoptosis
migration.
In
addition,
we
have
illustrated
implications
MCOLN1-regulated
pathological
cancer
myocardial
ischemia-reperfusion
(I/R)
injury.
summary,
given
involvement
MCOLN1-mediated
pathogenesis
I/R
injury,
targeting
May
provide
clues
developing
new
therapeutic
strategies
treatment
these
diseases.
Exploring
regulation
diverse
diseases
contexts
will
surely
broaden
our
understanding
pathway
offer
potential
promising
drug
target.
