Cells,
Год журнала:
2024,
Номер
13(12), С. 997 - 997
Опубликована: Июнь 7, 2024
Chronic
pain
is
a
pathological
state
defined
as
daily
sensation
over
three
consecutive
months.
It
affects
up
to
30%
of
the
general
population.
Although
significant
research
efforts
have
been
made
in
past
30
years,
only
few
and
relatively
low
effective
molecules
emerged
treat
chronic
pain,
with
considerable
translational
failure
rate.
Most
preclinical
models
focused
on
sensory
neurotransmission,
particular
emphasis
dorsal
horn
spinal
cord
first
relay
nociceptive
information.
Beyond
impaired
transmission,
also
accompanied
by
numerous
comorbidities,
such
anxiety-depressive
disorders,
anhedonia
motor
cognitive
deficits
gathered
under
term
"pain
matrix".
The
emergence
cutting-edge
techniques
assessing
specific
neuronal
circuits
allow
in-depth
studies
connections
between
matrix"
behavioural
outputs.
Pain
behaviours
are
assessed
not
reflex-induced
responses
but
various
or
more
complex
order
obtain
most
complete
picture
an
animal's
state.
This
review
summarises
latest
findings
modulation
brain
component
matrix
proposes
new
opportunities
unravel
mechanisms
pain.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Июнь 8, 2024
Abstract
Pain
is
estimated
to
affect
more
than
20%
of
the
global
population,
imposing
incalculable
health
and
economic
burdens.
Effective
pain
management
crucial
for
individuals
suffering
from
pain.
However,
current
methods
assessment
treatment
fall
short
clinical
needs.
Benefiting
advances
in
neuroscience
biotechnology,
neuronal
circuits
molecular
mechanisms
critically
involved
modulation
have
been
elucidated.
These
research
achievements
incited
progress
identifying
new
diagnostic
therapeutic
targets.
In
this
review,
we
first
introduce
fundamental
knowledge
about
pain,
setting
stage
subsequent
contents.
The
review
next
delves
into
underlying
disorders,
including
gene
mutation,
epigenetic
modification,
posttranslational
inflammasome,
signaling
pathways
microbiota.
To
better
present
a
comprehensive
view
research,
two
prominent
issues,
sexual
dimorphism
comorbidities,
are
discussed
detail
based
on
findings.
status
quo
evaluation
manipulation
summarized.
A
series
improved
innovative
strategies,
such
as
therapy,
monoclonal
antibody,
brain-computer
interface
microbial
intervention,
making
strides
towards
application.
We
highlight
existing
limitations
future
directions
enhancing
quality
preclinical
research.
Efforts
decipher
complexities
pathology
will
be
instrumental
translating
scientific
discoveries
practice,
thereby
improving
bench
bedside.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(6), С. 5378 - 5378
Опубликована: Март 11, 2023
Chronic
pain
affects
many
people
world-wide,
and
this
number
is
continuously
increasing.
There
a
clear
link
between
chronic
the
development
of
cardiovascular
disease
through
activation
sympathetic
nervous
system.
The
purpose
review
to
provide
evidence
from
literature
that
highlights
direct
relationship
system
dysfunction
pain.
We
hypothesize
maladaptive
changes
within
common
neural
network
regulating
perception
contribute
overactivation
in
setting
clinical
highlight
basic
neurocircuitry
linking
nociceptive
networks
overlap
controlling
two.
Cell Reports,
Год журнала:
2024,
Номер
43(4), С. 114057 - 114057
Опубликована: Апрель 1, 2024
Pain
that
persists
beyond
the
time
required
for
tissue
healing
and
pain
arises
in
absence
of
injury,
collectively
referred
to
as
nociplastic
pain,
are
poorly
understood
phenomena
mediated
by
plasticity
within
central
nervous
system.
The
parabrachial
nucleus
(PBN)
is
a
hub
relays
aversive
sensory
information
appears
play
role
nociplasticity.
Here,
preventing
PBN
Calca
neurons
from
releasing
neurotransmitters,
we
demonstrate
activation
necessary
manifestation
maintenance
chronic
pain.
Additionally,
directly
stimulating
neurons,
neuron
activity
sufficient
drive
Aversive
stimuli
multiple
modalities,
such
exposure
nitroglycerin,
cisplatin,
or
lithium
chloride,
can
nociplasticity
Calca-neuron-dependent
manner.
events
form
increased
excitability;
however,
neuroplasticity
also
occur
downstream
circuitry.
NeuroImage Clinical,
Год журнала:
2023,
Номер
40, С. 103531 - 103531
Опубликована: Янв. 1, 2023
Migraine
is
underpinned
by
central
nervous
system
neuroplastic
alterations
thought
to
be
caused
the
repetitive
peripheral
afferent
barrage
brain
receives
during
headache
phase
(cortical
hyperexcitability).
Calcitonin
gene-related
peptide
monoclonal
antibodies
(anti-CGRP-mAbs)
are
highly
effective
migraine
preventative
treatments.
Their
ability
alter
morphometry
in
treatment-responders
vs.
non-responders
not
well
understood.
Our
aim
was
determine
effects
of
anti-CGRP-mAb
galcanezumab
on
cortical
thickness
after
3-month
treatment
patients
with
high-frequency
episodic
or
chronic
migraine.
High-resolution
magnetic
resonance
imaging
performed
pre-
and
post-treatment
36
patients.
In
this
group,
19
were
classified
responders
(≥50%
reduction
monthly
days)
17
considered
(<50%
days).
Following
cross-sectional
processing
analyze
baseline
differences
thickness,
two-stage
longitudinal
symmetrized
percent
change
conducted
investigate
treatment-related
changes.
At
baseline,
no
significant
found
between
non-responders.
After
treatment,
decreased
(compared
baseline)
observed
regions
somatosensory
cortex,
anterior
cingulate
medial
frontal
superior
gyrus,
supramarginal
gyrus.
Non-responders
demonstrated
left
dorsomedial
cortex
We
interpret
thinning
seen
responder
group
as
suggesting
that
head
pain
could
lead
changes
neural
swelling
dendritic
complexity
such
reflect
recovery
process
from
maladaptive
activity.
This
conclusion
further
supported
our
recent
study
showing
3
months
initiation,
incidence
premonitory
symptoms
prodromes
followed
decreases
but
themselves
(that
is,
relates
reductions
nociceptive
signals
responders).
speculate
a
much
longer
period
required
allow
return
more
‘normal’
functioning
state
whereby
occur.
Pain,
a
comorbidity
of
anxiety
disorders,
causes
substantial
clinical,
social,
and
economic
burdens.
Emerging
evidence
suggests
that
propofol,
the
most
commonly
used
general
anesthetic,
may
regulate
psychological
disorders;
however,
its
role
in
pain-associated
is
not
yet
described.
This
study
investigates
therapeutic
potential
single
dose
propofol
(100
mg
kg
Neuroscience Bulletin,
Год журнала:
2024,
Номер
40(7), С. 872 - 886
Опубликована: Янв. 5, 2024
The
prelimbic
cortex
(PL)
is
actively
engaged
in
pain
modulation.
infralimbic
(IL)
has
been
reported
to
regulate
the
PL.
However,
how
this
regulation
affects
remains
unclear.
In
present
study,
we
recorded
temporary
hyper-activity
of
PL
pyramidal
neurons
responding
nociceptive
stimuli,
but
a
hypo-function
IL
by
vivo
electrophysiological
recording
rats
with
peripheral
inflammation.
Manipulation
or
had
opposite
effects
on
thermal
hyperalgesia.
Furthermore,
functional
connectivity
and
chemogenetic
between
subregions
indicated
an
inhibitory
influence
Activation
pathway
from
alleviated
hyperalgesia,
whereas
its
inhibition
exacerbated
chronic
pain.
Overall,
our
results
suggest
new
mechanism
underlying
role
medial
prefrontal
pain:
leads
hyperactivity
PL,
which
regulates
thus
contributes
chronicity
