Bidirectional control of generalized absence epilepsy networks via real-time direct depolarization of thalamocortical neurons
Progress in Neurobiology,
Год журнала:
2025,
Номер
unknown, С. 102774 - 102774
Опубликована: Май 1, 2025
Язык: Английский
EEG microstates as an important marker of depression: A systematic review and meta-analysis
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 12, 2024
Abstract
This
study
conducts
a
literature
search
through
databases
such
as
PubMed,
Web
of
Science,
CNKI
(China
National
Knowledge
Infrastructure),
and
the
Cochrane
Library
to
collect
case-control
studies
on
microstates
in
patients
with
depression.
Conducting
bias
risk
assessment
using
Review
Manager
5.4,
meta-analysis
is
performed
Stata
18.0
14.0
software.
has
been
registered
Prospero,
CRD42024543793.
Our
research
results
suggest
that
increased
duration
frequency
microstate
A
may
serve
potential
biomarker
for
An
increase
parameter
B
also
observed
when
individuals
experience
anxiety.
The
coverage
C
are
closely
related
rumination
levels.
Abnormalities
D
among
some
depression
indicate
presence
comorbid
conditions
overlapping
mental
disorders
or
attention
executive
function
deficits.
provides
important
insights
into
identifying
symptoms
etiology
by
examining
differences
between
healthy
individuals.
Язык: Английский
Selective Modulation of Fear Memory in Non‐Rapid Eye Movement Sleep
Advanced Science,
Год журнала:
2024,
Номер
11(44)
Опубликована: Окт. 9, 2024
Abstract
Sleep
stabilizes
memories
for
their
consolidation,
but
how
to
modify
specific
fear
memory
during
sleep
remains
unclear.
Here,
it
is
reported
that
using
targeted
reactivation
(TMR)
reactivate
prior
learning
experience
in
non‐slow
wave
(NS)
inhibits
while
TMR
slow
(SWS)
enhances
mice.
Replaying
conditioned
stimulus
(CS)
affects
spindle
occurrence,
leading
the
reduction
or
enhancement
of
oscillation‐spindle
(SO‐spindle)
coupling
NS
and
SWS,
respectively.
Optogenetic
inhibition
pyramidal
neurons
frontal
association
cortex
(FrA)
abolishes
behavioral
effects
NS‐TMR
SWS‐TMR
by
modulating
SO‐spindle
coupling.
Notably,
calcium
imaging
L2/3
FrA
shows
CS
SWS
selectively
activity
previously
activated
conditioning
(FC+
neurons),
which
significantly
correlates
with
CS‐elicited
power
spectrum
density.
Intriguingly,
these
TMR‐induced
changes
FC+
further
correlate
mice
freezing
behavior,
suggesting
contributions
consolidation
memories.
The
findings
indicate
can
weaken
strengthen
memory,
correlation
substages
non‐rapid
eye
movement
(NREM)
sleep.
Язык: Английский
Abnormal cortical functional network and microstates alterations in depression: insights from effective connectivity and EEG microstates
2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM),
Год журнала:
2023,
Номер
50, С. 2535 - 2542
Опубликована: Дек. 5, 2023
Background:
Despite
potential
neural
mechanism
of
depression
being
the
object
a
thriving
field,
research
alterations
in
brain
functional
connections
is
not
entirely
clear.
In
this
context,
we
used
source-level
effective
connectivity
and
microstate
analysis
to
study
resting-state
activity
depression.Methods:
Resting-state
electroencephalogram
(EEG)
data
from
17
depressive
subjects
19
controls
were
included.
We
applied
multivariate
autoregressive
models
combined
independent
component
(MVARICA)
generalized
partial
directed
coherence
(GPDC)
analyze
system
(BFS)
induced
by
depression.
Further,
characterized
spatial
organization
temporal
dynamics
large-scale
cortical
activities
was
for
disease
understand
network
dynamics.
Results:
Compared
with
controls,
had
enhanced
information
flow
frontal
parietal
alpha
band.
Especially,
lobes
respectively
correspond
dominant
hub
abnormally
weaker
stronger
causal
pathways
patients
addition,
revealed
that
mean
duration,
occurrence
rate,
time
coverage
class
D
significantly
lower
compared
controls.
Meanwhile,
preferred
bilateral
transitions
between
C
Microstate
may
be
associated
frontoparietal
dorsal
attention
network,
findings
reflects
switching
reorientation
relevant
occur
more
frequently
depressed
patients.Conclusions:
Patients
exhibited
clear
Notably,
EEG
might
provide
useful
biomarkers
deviant
functions
clinical
researches
Язык: Английский
Dysfunctional brain dynamics in Subjects with major depression: An EEG microstate spectral analysis
2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM),
Год журнала:
2023,
Номер
40, С. 2527 - 2527
Опубликована: Дек. 5, 2023
Major
depressive
disorder
(MDD)
which
is
a
widespread
worldwide
cause
disruption
in
some
brain
functions
and
thus
leads
to
network
changes.
An
increasing
number
of
clinical
cognitive
neuroscience
studies
have
used
broadband
EEG
microstate
method
assess
the
electrical
activity
large-scale
cortical
networks;
however,
topographic
frequency
patterns
different
categories
MDD
patients
are
not
clear.
In
this
study,
spectra
were
analyzed
using
5-min
resting-state
electroencephalography
(EEG)
data
from
55
subjects
(including
27
28
healthy
controls)
with
variational
empirical
mode
decomposition
Hilbert-Huang
transform.
The
results
showed
that
D
other
microstates
(A,
C,
E)
display
opposite
patterns.
Most
specifically,
beta
band,
marginal
spectral
energies
A,
E
increased
compared
HCs,
while
energy
was
decreased.
Meanwhile,
we
observed
A
C
band
positively
correlated
severity
symptoms,
suggesting
alterations
can
serve
as
an
important
reference
for
disease
progression.
These
confirm
abnormalities
beta-band
patient
provide
new
perspective
exploring
psychomotor
function
MDD.
Язык: Английский