Enhancing adipose tissue plasticity: progenitor cell roles in metabolic health

Nature Reviews Endocrinology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 6, 2025

Язык: Английский

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Sex steroid hormones mediate the association between neonicotinoids and obesity among children and adolescents

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 289, С. 117708 - 117708

Опубликована: Янв. 1, 2025

Neonicotinoids are the most widely used insecticide worldwide. Toxicological and epidemiological studies suggest that exposure to neonicotinoid may be linked development of childhood obesity. However, evidence is limited. To investigate association between obesity among U.S. children adolescents explore underlying mechanism mediated by serum sex steroid hormones in these associations. Data from 2015-2016 National Health Nutrition Examination Survey were for analysis. Generalized linear regression was detectable neonicotinoids ten measures The interaction effects multiple determined Chi-squared Automatic Interaction Detection method. Mediation analysis assess potential mediators hormones, including testosterone (T), estradiol (E Clothianidin (β = -0.29, 95 % CI: -0.57, -0.01) N-desmethyl-acetamiprid -0.19, -0.35, -0.03) associated with reduced VFI z-score. After stratification, 5-hydroxy-imidacloprid positively risk general males (OR=2.24, 1.20, 4.20) a probability 52.5 %. FAI 15 obesity, SHBG 30 increased showed associations but results mixed sex-specific. Sex play role mediating on

Язык: Английский

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Organ-Specific Responses to Chronic High-Fat Diets in Mice: Insights into Phospholipid Fatty Acid Distribution

Nutrients, Год журнала: 2025, Номер 17(5), С. 821 - 821

Опубликована: Фев. 27, 2025

Background/Objectives: This research aimed to investigate phospholipid fatty acid (PLFA) distribution in the brain, kidneys, and white adipose tissue (WAT) lipid profiles response high-fat diets. Methods: Adult female C57BL/6 mice were fed diets containing 25% linseed, palm, or sunflower oil for 100 days. The composition of dietary oils PL analyzed using gas-liquid chromatography. Results: Linseed increased n-3 polyunsaturated acids (PUFAs) with subsequent conversion into long-chain PUFAs brain kidney PL, while only alpha-linolenic was elevated WAT. Palm resulted unique PLFA distributions kidneys raised linoleic without pro-inflammatory n-6 PUFAs. Sunflower saturated palmitic acid, as opposed rise monounsaturated oleic acid. also significantly improved profiles, reducing LDL increasing HDL levels enhancing cardiovascular indices. Conclusions: study demonstrates that impact organ-specific linseed enriching renal PUFAs, palm induce distinct modifications Moreover, offers notable cardioprotective benefits due favorable profile changes. These findings highlight importance fat selection achieving balanced metabolism suggest diverse combinations may be essential optimizing health outcomes.

Язык: Английский

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Innervation of Adipocytes is Limited in Mouse Perivascular Adipose Tissue

AJP Heart and Circulatory Physiology, Год журнала: 2024, Номер 327(1), С. H155 - H181

Опубликована: Май 24, 2024

Perivascular adipose tissue (PVAT) regulates vascular tone by releasing anticontractile factors. These factors are driven processes downstream of adipocyte stimulation norepinephrine; however, whether norepinephrine originates from neural innervation or other sources is unknown. The goal this study was to test the hypothesis that neurons innervating PVAT provide adrenergic drive stimulate adipocytes in aortic and mesenteric perivascular (aPVAT mPVAT), white (WAT). Healthy male female mice (8-13 wk) were used all experiments. Expression genes associated with synaptic transmission quantified qPCR activity response neurotransmitters neuron depolarization assessed

Язык: Английский

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Metabolic Changes in Patients with Premature Ovarian Insufficiency: Adipose Tissue Focus—A Narrative Review

Metabolites, Год журнала: 2025, Номер 15(4), С. 242 - 242

Опубликована: Апрель 2, 2025

Background: Estrogen plays a crucial role in adipose tissue homeostasis, influencing fat distribution, lipid metabolism, and insulin sensitivity. Through estrogen receptor (ER) activation, particularly ERα, estradiol (E2) regulates adipogenesis, inhibits adipocyte hypertrophy, promotes signaling. It enhances oxidation, reduces lipogenesis, suppresses pro-inflammatory cytokine production, thereby maintaining metabolic health. Primary ovarian insufficiency (POI), characterized by deficiency before the age of 40, disrupts this regulatory network, leading to adverse effects. Objetives: This review examines effects on tissue, carbohydrate with particular focus clinical evidence women POI. Methods: A narrative alterations associated POI, emphasizing molecular, biochemical, mechanisms underlying deficiency, special tissue. Results: Women POI exhibit increased visceral accumulation, reduced lean mass, adipokine secretion, resembling phenotype postmenopausal women. The decline levels contributes central adiposity, impaired resistance, exacerbating risk type 2 diabetes (T2D) cardiovascular disease (CVD). loss estrogenic regulation leads enhanced lipolysis fat, raising free fatty acid flux liver, promoting hepatic steatosis, worsening resistance. Studies indicate that patients have significantly higher total cholesterol, low-density lipoprotein (LDL) triglycerides compared age-matched controls, reinforcing their heightened CVD risk. Reduced sex hormone-binding globulin (SHBG) increase androgen availability, aggravating deposition. These disturbances can potentially accelerate atherosclerosis vascular aging, increasing morbidity mortality patients. Conclusions: Understanding its disruption highlights importance early intervention. Although available is limited largely extrapolated from menopause studies, strategies such as hormone replacement therapy, lifestyle modifications, profile optimization are essential mitigate consequences improve long-term health outcomes

Язык: Английский

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Diabetes mellitus in breast cancer survivors: metabolic effects of endocrine therapy

Nature Reviews Endocrinology, Год журнала: 2023, Номер 20(1), С. 16 - 26

Опубликована: Окт. 2, 2023

Язык: Английский

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Characterisation of neurogenic lipolytic responses in white adipose tissue ex vivo

British Journal of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 2, 2025

Background and Purpose Dysfunction of the autonomic nervous system is associated with cardiovascular dysfunction, including metabolic syndrome obesity. Understanding mechanisms neurogenic control white adipose tissue key to understanding physiology pathophysiology, though there limited research exploring this in using pharmacological tools, as opposed genetic knockout models. Experimental Approach Inguinal from C57BL/6J mice was used study. We immunocytochemistry determine innervation glycerol release assays quantify lipolysis isolated adipocytes. The voltage‐gated Na + channel opener veratridine stimulate activity ex vivo. role neurotransmitters receptors mediating veratridine‐evoked pharmacologically characterised. Key Results Veratridine evoked but not This abolished by tetrodotoxin propranolol. also induced noradrenaline tissue. Veratridine‐ noradrenaline‐evoked blocked β 2 ‐adrenoceptor antagonist ICI‐118551 1 CGP 20712A. Purported 3 antagonists L‐748337 SR59230A stimulated Neither or antagonised release. exclude contributions sensory neuropeptides neuropeptide Y ATP. Conclusion Implications Neurogenic lipolytic responses can be measured vivo nerve activity. are mediated activation. study provides first evidence

Язык: Английский

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Arthrocolin B Impairs Adipogenesis via Delaying Cell Cycle Progression During the Mitotic Clonal Expansion Period

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1474 - 1474

Опубликована: Фев. 10, 2025

Obesity and its related diseases severely threaten people's health, causing persistently high morbidity mortality worldwide. The abnormal proliferation hypertrophy of adipocytes mediate the expansion adipose tissue, which is main cause obesity-related diseases. Inhibition cell during mitotic clonal (MCE) period adipogenesis may be a promising strategy for preventing treating obesity. Arthrocolins are series fluorescent dye-like complex xanthenes from engineered Escherichia coli, with potential anti-tumor antifungal activities. However, role underlying mechanisms these compounds in adipocyte differentiation remain unclear. In this study, we discovered that arthrocolin B, member family, significantly impeded by accumulation lipid droplets triglycerides, as well downregulating expression key factors involved adipogenesis, such SREBP1, C/EBPβ, C/EBPδ, C/EBPα, PPARγ, FABP4. Moreover, revealed inhibition might consequence cycle arrest MCE differentiation, most likely modulating p53, AKT, ERK pathways, upregulating p21 p27, repressing CDK1, CDK4, Cyclin A2, D1, p-Rb. Additionally, B could promote CPT1A implying fatty acid oxidation. Overall, our research concludes has ability to suppress early stages mainly signaling proteins progression. This work broadens understanding function arthrocolins regulation provide lead compound

Язык: Английский

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Dietary oleic acid drives obesogenic adipogenesis via modulation of LXRα signaling

Cell Reports, Год журнала: 2025, Номер 44(4), С. 115527 - 115527

Опубликована: Апрель 1, 2025

Dietary fat composition has changed substantially during the obesity epidemic. As adipocyte hyperplasia is a major mechanism of adipose expansion, we aim to ascertain how dietary fats affect adipogenesis obesity. We employ an unbiased screen identify oleic acid (OA) as only fatty that induces obesogenic at physiologic levels and show plasma monounsaturated acids (MUFAs), which are mostly OA, associated with human OA stimulates in mouse precursor cells (APCs) by increasing AKT2 signaling, hallmark hyperplasia, reducing LXR activity. High consumption decreases LXRα Ser196 phosphorylation APCs, while blocking results APC hyperproliferation. increasingly being incorporated into due purported health benefits, our finding unique regulator biology underscores importance understanding high affects metabolic health.

Язык: Английский

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14-3-3ζ allows for adipogenesis by modulating chromatin accessibility during the early stages of adipocyte differentiation

Molecular Metabolism, Год журнала: 2025, Номер 97, С. 102159 - 102159

Опубликована: Апрель 28, 2025

Язык: Английский

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