European Journal of Immunology,
Год журнала:
2024,
Номер
54(12)
Опубликована: Сен. 12, 2024
G
protein-coupled
receptors
(GPCRs)
are
vital
cell
surface
that
govern
a
myriad
of
physiological
functions.
Despite
their
crucial
role
in
regulating
antitumor
immunity
and
tumorigenesis,
therapeutic
applications
targeting
GPCRs
oncology
currently
limited.
This
review
offers
focused
examination
selected
protumorigenic
chemokine
metabolite-sensing
GPCRs.
Specifically,
the
highlights
five
able
to
orchestrate
tumor
immunobiology
at
three
main
levels:
immunity,
cancer
expansion,
blood
vessel
development.
The
culminates
by
illuminating
emerging
therapies
discussing
innovative
strategies
harness
full
potential
GPCR-targeted
treatments,
applying
multireceptor
patient-specific
logic.
npj Biofilms and Microbiomes,
Год журнала:
2025,
Номер
11(1)
Опубликована: Март 25, 2025
Accumulating
data
suggest
that
remodeling
aged
gut
microbiota
improves
aging-related
imbalance
in
intestinal
homeostasis.
However,
evidence
favor
of
the
beneficial
effect
on
stress
and
immune
responses
during
aging
is
scarce.
The
current
study
revealed
old
mice
presented
impaired
barrier
integrity.
Transcriptome
sequencing
coupled
with
bioinformatics
analysis
altered
gene
expression
profiles
colon
mesenteric
lymph
nodes,
which
are
involved
mainly
responses,
respectively.
Notably,
was
closely
related
to
differentially
expressed
genes.
Microbiota
depletion
ameliorated
integrity
partially
reversed
inflammatory
factors
upregulated
mice.
Furthermore,
fecal
transplantation
from
young
resulted
a
significant
improvement
These
findings
highlight
potential
microbiota-targeted
interventions
physiological
processes
call
for
further
investigation.
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 2, 2025
Kynurenic
acid
(KYNA)
is
one
of
the
metabolites
tryptophan
(Trp),
which
can
be
supplied
by
endogenous
synthesis
or
diet
and
involves
various
aspects
nutrition
metabolism.
KYNA
has
been
proven
to
an
antagonist
α7-nicotinic
acetylcholine
NMDA
receptors,
regulate
neurotransmission
cholinergic
glutaminergic
acid,
so
mainly
associated
with
neurodegenerative
diseases.
Other
in
Trp
kynurenine
metabolic
pathways,
such
as
3-hydroxy-l-kynurenine
(3-HK),
5-hydroxytryptophan
(5-HT),
quinolinic
(QA),
are
also
involved
immune
regulation
have
pro-stimulatory
anti-excitatory
toxicity.
present
both
human
body
daily
diet,
it
potential
a
new
dietary
supplement.
It
may
great
significance
treating
psychiatric
disorders.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(19), С. 14756 - 14756
Опубликована: Сен. 29, 2023
The
bidirectional
communication
between
the
gut
and
central
nervous
system
(CNS)
through
microbiota
is
known
as
microbiota–gut–brain
axis.
brain,
enteric
neural
innervation
vagus
nerve,
influences
physiological
activities
(motility,
mucin,
peptide
secretion),
well
development
of
mucosal
immune
system.
Conversely,
can
influence
CNS
via
intestinal
microbiota,
its
metabolites,
gut-homing
cells.
Growing
evidence
suggests
that
immunity
critically
involved
in
gut–brain
during
health
diseases,
including
multiple
sclerosis
(MS).
function
immunity,
conversely,
innate
adaptive
composition.
Gut
systemic
along
with
are
perturbed
MS.
Diet
disease-modifying
therapies
(DMTs)
affect
composition
microbial
community,
leading
to
changes
peripheral
which
ultimately
affects
A
high-fat
diet
highly
associated
dysbiosis-mediated
inflammation
permeability,
while
a
high-fiber
diet/short-chain
fatty
acids
(SCFAs)
promote
Foxp3
Tregs
improvement
barrier
function,
subsequently
suppress
autoimmunity
animal
model
MS
(experimental
autoimmune
encephalomyelitis
or
EAE).
This
review
will
address
role
modulation
by
DMTs
pathophysiology.
Frontiers in Cellular Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Авг. 8, 2024
The
Aryl
hydrocarbon
receptor
(AHR)
is
a
cytosolic
and
ligand-activated
transcription
factor
widely
expressed
across
various
cell
types
in
the
body.
Its
signaling
vital
for
host
responses
at
barrier
sites,
regulating
epithelial
renewal,
integrity,
activities
of
several
immune
cells.
This
makes
AHR
essential
cellular
during
aging,
especially
those
governing
inflammation
immunity.
In
this
review,
we
provided
an
overview
mechanisms
by
which
mediates
inflammatory
response
gut
brain
level
through
signals
from
intestinal
microbes.
age-related
reduction
microbiota
functions
perceived
as
trigger
aberrant
linking
to
neurodegeneration.
Thus,
explored
microbiome
impact
on
nature
availability
ligands
outcomes
pathways
involved
neurodegenerative
diseases
age-associated
decline
functions,
with
insight
Parkinson's
Alzheimer's
diseases,
most
common
elderly.
Specifically,
focused
microbial
tryptophan
catabolism
responsible
production
ligands.
Perspectives
development
microbiota-based
interventions
targeting
activity
are
presented
healthy
aging.
Journal of Pharmacology and Experimental Therapeutics,
Год журнала:
2024,
Номер
389(1), С. 76 - 86
Опубликована: Янв. 30, 2024
Mast
cell
stabilizers,
including
disodium
cromoglycate
(DSCG),
were
found
to
have
potential
as
the
agonists
of
an
orphan
G
protein–coupled
receptor,
GPR35,
although
it
remains
be
determined
whether
GPR35
is
expressed
in
mast
cells
and
involved
suppression
degranulation.
Our
purpose
this
study
verify
expression
clarify
how
modulates
We
explored
roles
using
system,
a
line
constitutively
expressing
rat
peritoneal
cells,
bone
marrow–derived
cultured
cells.
Immediate
allergic
responses
assessed
IgE-mediated
passive
cutaneous
anaphylaxis
(PCA)
model.
Various
known
agonists,
DSCG
newly
designed
compounds,
suppressed
was
mature
but
not
immature
line.
Degranulation
induced
by
antigens
significantly
downmodulated
stably
GPR35.
A
agonist,
zaprinast,
transient
activation
RhoA
decrease
amount
filamentous
actin.
PCA
wild-type
mice
GPR35−/−
mice.
These
findings
suggest
that
should
prevent
from
undergoing
degranulation
antigen
stimulation
primary
target
stabilizers.
SIGNIFICANCE
STATEMENT
The
cromoglycate,
suppress
mouse
their
antiallergic
effects
abrogated
mice,
indicating
stabilizers
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Сен. 3, 2024
Abstract
Background
Periodontitis
results
from
host-microbe
dysbiosis
and
the
resultant
dysregulated
immunoinflammatory
response.
Importantly,
it
closely
links
to
numerous
systemic
comorbidities,
perplexingly
contributes
adverse
pregnancy
outcomes
(APOs).
Currently,
there
are
limited
studies
on
distal
consequences
of
periodontitis
via
oral-gut
axis
in
pregnant
women.
This
study
investigated
integrative
microbiome-metabolome
profiles
through
multi-omics
approaches
first-trimester
women
explored
translational
potentials.
Methods
We
collected
samples
subgingival
plaques,
saliva,
sera
stool
54
Chinese
at
first
trimester,
including
31
maternal
(Perio)
subjects
23
Non-Perio
controls.
By
integrating
16S
rRNA
sequencing,
untargeted
metabolomics
clinical
traits,
we
microbial
metabolic
connection
resulting
among
early
Results
demonstrated
a
novel
bacterial
distinguisher
Coprococcus
feces
association
with
periodontopathogens,
being
different
other
fecal
genera
Lachnospiraceae
family.
The
ratio
Lachnoclostridium
could
discriminate
between
Perio
groups
as
Porphyromonas
Rothia
did.
Furthermore,
were
differentially
abundant
features
pivotally
enriched
like
L-urobilin
kynurenic
acid.
revealed
periodontitis-oriented
network
cluster,
which
was
centered
well
serum
triglyceride.
Conclusions
current
findings
about
notable
influence
microbiota
metabolites
signify
importance
implications
preconceptional
oral/periodontal
healthcare
for
enhancing
wellbeing.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Авг. 12, 2024
The
incidence
of
duodenal
tumors
(DTs)
is
increasing.
However,
the
mechanisms
underlying
its
development
remain
unclear.
Environmental
factors,
including
microbiome
and
bile
acids
(BAs),
are
believed
to
influence
tumor
development.
Therefore,
we
conducted
a
single-center,
prospective,
observational
study
investigate
potential
differences
between
patients
with
DTs
healthy
controls
(HCs)
based
on
these
factors.
In
addition,
BAs
in
fluid
were
measured
using
liquid
chromatography-tandem
mass
spectrometry.
We
recruited
41
performed
16S
rRNA-seq.
There
was
no
difference
observed
ASVs
or
PCoA
plot
Bray-Curtis
dissimilarity
HCs.
lithocholic
acid
concentration
significantly
lower
DT
group
than
control
group.
ratio
CDCA
LCA
higher
DTs.
No
significant
microbiota
DTs,
