Regulation of adult neurogenesis: the crucial role of astrocytic mitochondria DOI Creative Commons
Danping Liu, Pei Guo,

Yi Wang

и другие.

Frontiers in Molecular Neuroscience, Год журнала: 2024, Номер 17

Опубликована: Ноя. 22, 2024

Neurogenesis has emerged as a promising therapeutic approach for central nervous system disorders. The role of neuronal mitochondria in neurogenesis is well-studied, however, recent evidence underscores the critical astrocytic mitochondrial function regulating and underlying mechanisms remain incompletely understood. This review highlights regulatory effects astrocyte on neurogenesis, focusing metabolic support, calcium homeostasis, secretion neurotrophic factors. effect dysfunction pathophysiology treatment strategies Alzheimer’s disease depression discussed. Greater attention needed to investigate autophagy, dynamics, biogenesis, energy metabolism neurogenesis. Targeting presents potential strategy enhancing neural regeneration.

Язык: Английский

Link Between Obsessive-Compulsive Disorder and ApoE Gene Polymorphisms[Letter] DOI Creative Commons

Luyi Xu,

Cheng Mei

Neuropsychiatric Disease and Treatment, Год журнала: 2024, Номер Volume 20, С. 1797 - 1798

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

1

Aerobic exercise improves astrocyte mitochondrial quality and transfer to neurons in a mouse model of Alzheimer's disease DOI Creative Commons
Jiachen Cai, Yan Chen,

Yueqin She

и другие.

Brain Pathology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 26, 2024

Abstract Mitochondrial dysfunction is a well‐established hallmark of Alzheimer's disease (AD). Despite recent documentation transcellular mitochondrial transfer, its role in the pathogenesis AD remains unclear. In this study, we report an impairment quality within astrocytes and neurons adult 5 × FAD mice. Following treatment with mitochondria isolated from aged induced by exposure to amyloid protein or extended cultivation, cultured exhibited excessive generation reactive oxygen species underwent neurite atrophy. Notably, aerobic exercise enhanced upregulating CD38 hippocampal Conversely, knockdown diminished astrocytic–neuronal thereby abolishing ameliorative effects on neuronal oxidative stress, β‐amyloid plaque deposition, cognitive These findings unveil unexpected mechanism through which facilitates transference healthy neurons, thus countering AD‐like progression.

Язык: Английский

Процитировано

1

Environmentally Relevant Lead Exposure Impacts Gene Expression in SH-SY5Y Cells Throughout Neuronal Differentiation DOI Creative Commons
Rachel K. Morgan, Anagha Tapaswi, Katelyn M. Polemi

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 3, 2024

Abstract Lead (Pb) causes learning and memory impairments, but the molecular effects of continuous, environmentally relevant levels exposure on key neurodevelopmental processes are not fully characterized. Here we examine a range Pb concentrations (0.16μM, 1.26μM, 10μM Pb) relative to control neural differentiation in SH-SY5Y cell model. began day 5 was continuous for remaining days, after which assessed transcriptome via RNA sequencing at several time points. The bulk detected changes gene expression occurred with condition. Interestingly, associated lower two exposures were stage-specific, aberrant genes (e.g., COL3A1 , HMOX1 CCL2 ) observed during days 9, 12, 15 both 0.16μM 1.26μM conditions, disappeared by concluded 18. We six co-expression clusters differentiation, 10uM significantly perturbed clusters, one involved cycling DNA repair other protein synthesis. Benchmark concentration analysis identified many affected or below current US standard (3.5μg/dL) these enriched pathways including stress responses, repair, misfolded response, mitosis, neurotransmitter production. This work highlights potential new mechanisms impact throughout result long-lasting implications health cognition.

Язык: Английский

Процитировано

1

How can early stress influence later Alzheimer risk? Possible mediators and underlying mechanisms. DOI Creative Commons
Paul J. Lucassen, Anikó Kőrösi, Susanne R. de Rooij

и другие.

Biological Psychiatry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

1

Regulation of adult neurogenesis: the crucial role of astrocytic mitochondria DOI Creative Commons
Danping Liu, Pei Guo,

Yi Wang

и другие.

Frontiers in Molecular Neuroscience, Год журнала: 2024, Номер 17

Опубликована: Ноя. 22, 2024

Neurogenesis has emerged as a promising therapeutic approach for central nervous system disorders. The role of neuronal mitochondria in neurogenesis is well-studied, however, recent evidence underscores the critical astrocytic mitochondrial function regulating and underlying mechanisms remain incompletely understood. This review highlights regulatory effects astrocyte on neurogenesis, focusing metabolic support, calcium homeostasis, secretion neurotrophic factors. effect dysfunction pathophysiology treatment strategies Alzheimer’s disease depression discussed. Greater attention needed to investigate autophagy, dynamics, biogenesis, energy metabolism neurogenesis. Targeting presents potential strategy enhancing neural regeneration.

Язык: Английский

Процитировано

1