Frontiers in Molecular Neuroscience,
Год журнала:
2024,
Номер
17
Опубликована: Ноя. 22, 2024
Neurogenesis
has
emerged
as
a
promising
therapeutic
approach
for
central
nervous
system
disorders.
The
role
of
neuronal
mitochondria
in
neurogenesis
is
well-studied,
however,
recent
evidence
underscores
the
critical
astrocytic
mitochondrial
function
regulating
and
underlying
mechanisms
remain
incompletely
understood.
This
review
highlights
regulatory
effects
astrocyte
on
neurogenesis,
focusing
metabolic
support,
calcium
homeostasis,
secretion
neurotrophic
factors.
effect
dysfunction
pathophysiology
treatment
strategies
Alzheimer’s
disease
depression
discussed.
Greater
attention
needed
to
investigate
autophagy,
dynamics,
biogenesis,
energy
metabolism
neurogenesis.
Targeting
presents
potential
strategy
enhancing
neural
regeneration.
Abstract
Mitochondrial
dysfunction
is
a
well‐established
hallmark
of
Alzheimer's
disease
(AD).
Despite
recent
documentation
transcellular
mitochondrial
transfer,
its
role
in
the
pathogenesis
AD
remains
unclear.
In
this
study,
we
report
an
impairment
quality
within
astrocytes
and
neurons
adult
5
×
FAD
mice.
Following
treatment
with
mitochondria
isolated
from
aged
induced
by
exposure
to
amyloid
protein
or
extended
cultivation,
cultured
exhibited
excessive
generation
reactive
oxygen
species
underwent
neurite
atrophy.
Notably,
aerobic
exercise
enhanced
upregulating
CD38
hippocampal
Conversely,
knockdown
diminished
astrocytic–neuronal
thereby
abolishing
ameliorative
effects
on
neuronal
oxidative
stress,
β‐amyloid
plaque
deposition,
cognitive
These
findings
unveil
unexpected
mechanism
through
which
facilitates
transference
healthy
neurons,
thus
countering
AD‐like
progression.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 3, 2024
Abstract
Lead
(Pb)
causes
learning
and
memory
impairments,
but
the
molecular
effects
of
continuous,
environmentally
relevant
levels
exposure
on
key
neurodevelopmental
processes
are
not
fully
characterized.
Here
we
examine
a
range
Pb
concentrations
(0.16μM,
1.26μM,
10μM
Pb)
relative
to
control
neural
differentiation
in
SH-SY5Y
cell
model.
began
day
5
was
continuous
for
remaining
days,
after
which
assessed
transcriptome
via
RNA
sequencing
at
several
time
points.
The
bulk
detected
changes
gene
expression
occurred
with
condition.
Interestingly,
associated
lower
two
exposures
were
stage-specific,
aberrant
genes
(e.g.,
COL3A1
,
HMOX1
CCL2
)
observed
during
days
9,
12,
15
both
0.16μM
1.26μM
conditions,
disappeared
by
concluded
18.
We
six
co-expression
clusters
differentiation,
10uM
significantly
perturbed
clusters,
one
involved
cycling
DNA
repair
other
protein
synthesis.
Benchmark
concentration
analysis
identified
many
affected
or
below
current
US
standard
(3.5μg/dL)
these
enriched
pathways
including
stress
responses,
repair,
misfolded
response,
mitosis,
neurotransmitter
production.
This
work
highlights
potential
new
mechanisms
impact
throughout
result
long-lasting
implications
health
cognition.
Frontiers in Molecular Neuroscience,
Год журнала:
2024,
Номер
17
Опубликована: Ноя. 22, 2024
Neurogenesis
has
emerged
as
a
promising
therapeutic
approach
for
central
nervous
system
disorders.
The
role
of
neuronal
mitochondria
in
neurogenesis
is
well-studied,
however,
recent
evidence
underscores
the
critical
astrocytic
mitochondrial
function
regulating
and
underlying
mechanisms
remain
incompletely
understood.
This
review
highlights
regulatory
effects
astrocyte
on
neurogenesis,
focusing
metabolic
support,
calcium
homeostasis,
secretion
neurotrophic
factors.
effect
dysfunction
pathophysiology
treatment
strategies
Alzheimer’s
disease
depression
discussed.
Greater
attention
needed
to
investigate
autophagy,
dynamics,
biogenesis,
energy
metabolism
neurogenesis.
Targeting
presents
potential
strategy
enhancing
neural
regeneration.
