Endogenous opioid receptors and the feast or famine of maladaptive feeding DOI Creative Commons

Ames K. Sutton Hickey,

Bridget A. Matikainen‐Ankney

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Март 6, 2025

Maladaptive feeding comprises unhealthy eating patterns that jeopardize survival, including over- and underconsumption. These behaviors are often coordinated by endogenous opioid receptors (EORs). Here, we explore the involvement of EORs in obesity anorexia nervosa (AN), two disorders associated with dysregulated behavior relevant animal models. While seemingly opposing metabo-psychiatric states, our goal is to highlight common circuit synaptic mechanisms underlying AN a focus on EOR functionality. We examine neural substrates maladaptive comorbid conditions pain, suggesting role for EOR-driven plasticity pathogenesis both AN.

Язык: Английский

Neuromodulator and neuropeptide sensors and probes for precise circuit interrogation in vivo DOI
Jessie Muir, Maribel Anguiano, Christina K. Kim

и другие.

Science, Год журнала: 2024, Номер 385(6716)

Опубликована: Сен. 26, 2024

To determine how neuronal circuits encode and drive behavior, it is often necessary to measure manipulate different aspects of neurochemical signaling in awake animals. Optogenetics calcium sensors have paved the way for these types studies, allowing perturbation readout spiking activity within genetically defined cell types. However, methods lack ability further disentangle roles individual neuromodulator neuropeptides on behavior. We review recent advances chemical biology tools that enable precise spatiotemporal monitoring control over neuroeffectors their receptors vivo. also highlight discoveries enabled by such tools, revealing molecules signal across timescales learning, orchestrate behavioral changes, modulate circuit activity.

Язык: Английский

Процитировано

11

Mu Opioid Agonistic Effect on Neuropeptide Gene Expression Levels Involved in Hypothalamic Feeding Regulation DOI
Fatma Bedia Karakaya Cimen, Zeliha Erkaya Turan, Aysu Şen

и другие.

Archives of Current Medical Research, Год журнала: 2025, Номер 6(1), С. 1 - 7

Опубликована: Янв. 30, 2025

Background: The regulation of food intake in the hypothalamus is one most complicated through integration various neuroendocrine mechanisms. In this region, orexigenic and anorexigenic peptides play a role by responding to different stimuli. Additionally, central opioidergic systems are involved feeding behavior. Several neuropeptides expressed also contribute intake. aim study was investigate effects mu agonist/antagonist molecules on both gene expression levels hypothalamus. Methods: our study, 48 male Wistar Albino rats were divided into 4 groups as control, morphine, naloxone morphine+naloxone. control group received subcutaneous SF solution for 5 days; morphine at dose 10 mg/kg/day administered days 3 mg/kg 1.5 hours after last injection: morphine+naloxone injection. Hypothalamus tissues isolated from brains end experimental period. Anorexigenic peptide analysed RT-PCR method. Differences between statistically analyzed using one-way factorial ANOVA Tukey post-hoc test. Results: Morphine administration results decrease OX2R LepR genes, but did not change ORXA, OX1R, AgRP, NPY, POMC expression. Naloxone increased AgRP NPY while decreasing OX2R, APLNR levels. Conclusions: Our findings suggest that may affect related nutrition metabolism Further studies needed clarify possible mechanistic opiodergic activity dependence manner.

Язык: Английский

Процитировано

0

Cannabinoids Drive Feeding Through Agrp Neurons DOI
Yavuz Yavuz,

Habibe Goren,

Bayram Yılmaz

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0

Endogenous opioid receptors and the feast or famine of maladaptive feeding DOI Creative Commons

Ames K. Sutton Hickey,

Bridget A. Matikainen‐Ankney

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Март 6, 2025

Maladaptive feeding comprises unhealthy eating patterns that jeopardize survival, including over- and underconsumption. These behaviors are often coordinated by endogenous opioid receptors (EORs). Here, we explore the involvement of EORs in obesity anorexia nervosa (AN), two disorders associated with dysregulated behavior relevant animal models. While seemingly opposing metabo-psychiatric states, our goal is to highlight common circuit synaptic mechanisms underlying AN a focus on EOR functionality. We examine neural substrates maladaptive comorbid conditions pain, suggesting role for EOR-driven plasticity pathogenesis both AN.

Язык: Английский

Процитировано

0