Strategic stabilization of arousal boosts sustained attention

Current Biology, Год журнала: 2024, Номер 34(18), С. 4114 - 4128.e6

Опубликована: Авг. 15, 2024

Arousal and motivation interact to profoundly influence behavior. For example, experience tells us that we have some capacity control our arousal when appropriately motivated, such as staying awake while driving a motor vehicle. However, little is known about how jointly decision computations, including if animals, rodents, adapt their state needs. Here, developed show results from an auditory, feature-based, sustained-attention task with intermittently shifting utility. We use pupil size estimate across wide range of states apply tailored signal-detection theoretic, hazard function, accumulation-to-bound modeling approaches in large cohort mice. find pupil-linked utility both major impacts on multiple aspects performance. Although substantial fluctuations persist conditions, mice partially stabilize near intermediate optimal level high. Behavioral analyses elements behavior improve during high influences some, but not all, them. Specifically, the likelihood timescale sensory evidence accumulation quantity accumulated per time step attending. In sum, establish specific decision-computational signatures arousal, motivation, interaction attention. So doing, provide experimental analysis framework for studying self-regulation neurotypical brains diseases attention-deficit/hyperactivity disorder.

Язык: Английский

---

Separating cognitive and motor processes in the behaving mouse

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Авг. 24, 2023

The cognitive processes supporting complex animal behavior are closely associated with ubiquitous movements responsible for our posture, facial expressions, ability to actively sample sensory environments, and other critical processes. These strongly related neural activity across much of the brain often highly correlated ongoing processes, making it challenging dissociate dynamics that support from those movements. In such cases, a issue is whether separable movements, or if they driven by common mechanisms. Here, we demonstrate how separability motor can be assessed, and, when separable, each component isolated. We establish novel two-context behavioral task in mice involves multiple show commonly observed taken contaminated When components isolated using approach subspace decomposition, find exhibit distinct dynamical trajectories. Further, properly accounting movement revealed largely separate populations cells encode variables, contrast "mixed selectivity" reported. Accurately isolating particular will essential developing conceptual computational models circuit function evaluating cell types which circuits composed.

Язык: Английский

---

Different state-dependence of population codes across cortex

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 26, 2024

During perceptual decision-making, behavioral performance varies with changes in internal states such as arousal, motivation, and strategy. Yet it is unknown how these affect information coding across cortical regions involved differing aspects of sensory perception decision-making. We recorded neural activity from the primary auditory cortex (AC) posterior parietal (PPC) mice performing a navigation-based sound localization task. then modeled transitions strategies used during task performance. Mice transitioned between three latent decision-making strategies: an 'optimal' state two 'sub-optimal' characterized by choice bias frequent errors. Performance strongly influenced population patterns association but not cortex. Surprisingly, individual PPC neurons was better explained external inputs variables suboptimal than optimal state. Furthermore, shared variability (coupling) strongest In AC, similarly weak all states. Together, findings indicate that more linked to

Язык: Английский

---

Orexin population activity precisely reflects net body movement across behavioral and metabolic states

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 16, 2024

Abstract Tracking net body movement in real time may enable the brain to estimate ongoing demands and thus better orchestrate muscle tone, energy balance, arousal. To identify neural populations specializing tracking movement, here we compared self-initiated movement-related activity across genetically-defined subcortical neurons mouse brain, including dopaminergic, glutamatergic, noradrenergic, key peptidergic neurons. We show that hypothalamic orexin/hypocretin-producing (HONs) are exceptionally precise movement-trackers, encoding multiple classified behaviors with a high degree of precision, independent head acceleration. This was so precise, video analysis reliably served as low-cost biometric for HON population activity. The internal nutritional states, occurred communication bandwidth distinct from blood glucose. At projection targets, orexin/hypocretin peptide outputs correlated projection-specific manner, indicating functional heterogeneity outputs. Finally, found not encoded same extent other related arousal or energy. These findings indicate orchestrators metabolism finely tuned encode constituting bridge multiplexing motor resources.

Язык: Английский

---

Internal states emerge early during learning of a perceptual decision-making task

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Summary Recent work has shown that during perceptual decision-making tasks, animals frequently alternate between different internal states or strategies. However, the question of how when these emerge learning remains an important open problem. Does animal multiple strategies from very start training, only after extensive exposure to a task? Here we address this by developing dynamic latent state model, which applied training data mice perform visual task. Remarkably, found exhibited distinct “engaged” and “biased” even early with apparent second session onward. Moreover, our model revealed gradual improvement in task performance over course arose combination two factors: (1) increased sensitivity stimuli across all states; (2) proportion time spent higher-accuracy relative biased disengaged states. These findings highlight power approach for characterizing temporal evolution learning.

Язык: Английский

---

Behavioral modulations can alter the visual tuning of neurons in the mouse thalamocortical pathway

Cell Reports, Год журнала: 2024, Номер 43(12), С. 114947 - 114947

Опубликована: Дек. 1, 2024

Язык: Английский

---

Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Окт. 23, 2023

The flow of neural activity across the neocortex during active sensory discrimination is constrained by task-specific cognitive demands, movements, and internal states. During behavior, brain appears to sample from a broad repertoire activation motifs. Understanding how these patterns local global are selected in relation both spontaneous task-dependent behavior requires in-depth study densely sampled at single neuron resolution large regions cortex. In significant advance toward this goal, we developed procedures record mesoscale 2-photon Ca

Язык: Английский

---