The inner core enables transient touch detection in the Pacinian corpuscle

Science Advances, Год журнала: 2025, Номер 11(9)

Опубликована: Фев. 26, 2025

Pacinian corpuscles detect transient touch and vibration in vertebrates. Corpuscles are composed of a mechanoreceptor afferent surrounded by lamellar Schwann cells (LSCs), enclosed multilayered outer core. The spatial arrangement these components their contribution to sensory tuning unclear. We report the three-dimensional architecture corpuscle reveal role its cellular detection. In prevailing model, core acts as mechanical filter that limits static low-frequency stimuli from reaching terminal—the presumed sole site show is dispensable for vibration; instead, properties arise inner By acting additional sensors, LSCs potentiate mechanosensitivity terminal, which detects via fast inactivating ion channels. Thus, functional enabled an interplay between mechanosensitive terminal

Язык: Английский

---

Mechanosensitive ion channel-related genes in hepatocellular carcinoma: Unraveling prognostic genes and their roles in drug resistance and immune modulation

Liver Research, Год журнала: 2025, Номер 9(1), С. 36 - 48

Опубликована: Янв. 21, 2025

Язык: Английский

---

Molecular identity of the mechanotransduction machinery in inner ear hair cells and mechanotransduction-linked hearing loss

Fundamental Research, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

---

Structural and functional dissection of the Pacinian corpuscle reveals an active role of the inner core in touch detection

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 26, 2024

Summary Pacinian corpuscles are rapidly adapting mechanoreceptor end-organs that detect transient touch and high-frequency vibration. In the prevailing model, these properties determined by outer core, which acts as a mechanical filter limiting static low-frequency stimuli from reaching afferent terminal—the sole site of detection in corpuscles. Here, we determine detailed 3D architecture corpuscular components reveal their contribution to detection. We show core is dispensable for rapid adaptation frequency tuning. Instead, arise inner composed gap junction-coupled lamellar Schwann cells (LSCs) surrounding terminal. By acting additional sensing structures, LSCs potentiate mechanosensitivity terminal, detects via fast-inactivating ion channels. propose model corpuscle function mediated an interplay between mechanosensitive terminal core. Highlights eFIB-SEM reveals entire (Herbst) Inner, not mediates tuning Afferent channels Mechanosensitive tune sensitivity

Язык: Английский

---

The Role of Mechanosensitive Piezo Channels in Chronic Pain

Journal of Pain Research, Год журнала: 2024, Номер Volume 17, С. 4199 - 4212

Опубликована: Дек. 1, 2024

Mechanosensitive Piezo channels are ion activated by mechanical stimuli, playing a crucial role in mechanotransduction processes and hypersensitivity. When these subjected to loading, membrane currents rise instantaneously, depolarizing activating voltage-gated calcium channels. This results an increase intracellular Ca

Язык: Английский

---

A novel suppressor of Piezo2 in rodent nociceptors

Trends in Neurosciences, Год журнала: 2024, Номер 47(7), С. 478 - 479

Опубликована: Май 17, 2024

Язык: Английский

---