A single-dose MCMV-based vaccine elicits long-lasting immune protection in mice against distinct SARS-CoV-2 variants DOI Creative Commons
Kristin Metzdorf, Henning Jacobsen, Yeonsu Kim

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Июль 25, 2024

Current vaccines against COVID-19 elicit immune responses that are overall strong but wane rapidly. As a consequence, the necessary booster shots have contributed to vaccine fatigue. Hence, would provide lasting protection needed, still unavailable. Cytomegaloviruses (CMVs) and uniquely responses. Used as vectors, they may be attractive tools obviate need for boosters. Therefore, we tested murine CMV (MCMV) vector in relevant preclinical models of immunization challenge. We previously developed recombinant MCMV expressing spike protein ancestral SARS-CoV-2 (MCMV

Язык: Английский

Neural network-assisted humanisation of COVID-19 hamster transcriptomic data reveals matching severity states in human disease DOI Creative Commons
Vincent D. Friedrich, Peter Pennitz, Emanuel Wyler

и другие.

EBioMedicine, Год журнала: 2024, Номер 108, С. 105312 - 105312

Опубликована: Сен. 23, 2024

Язык: Английский

Процитировано

1
A single-dose MCMV-based vaccine elicits long-lasting immune protection in mice against distinct SARS-CoV-2 variants DOI Creative Commons
Kristin Metzdorf, Henning Jacobsen, Yeonsu Kim

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Июль 25, 2024

Current vaccines against COVID-19 elicit immune responses that are overall strong but wane rapidly. As a consequence, the necessary booster shots have contributed to vaccine fatigue. Hence, would provide lasting protection needed, still unavailable. Cytomegaloviruses (CMVs) and uniquely responses. Used as vectors, they may be attractive tools obviate need for boosters. Therefore, we tested murine CMV (MCMV) vector in relevant preclinical models of immunization challenge. We previously developed recombinant MCMV expressing spike protein ancestral SARS-CoV-2 (MCMV

Язык: Английский

Процитировано

0