A Visual Circuit Linked To The Lateral Hypothalamus Mediates The Food Consumption-Suppressing And Weight Gain-Attenuating Effects Of Bright Light Treatment
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 28, 2025
Abstract
In
addition
to
its
well-established
role
in
vision,
environmental
light
also
plays
a
crucial
non-image-forming
visual
functions,
including
the
regulation
of
instinctive
behaviors
such
as
feeding.
Clinical
evidence
suggests
that
bright
therapy
can
alleviate
symptoms
individuals
with
obesity.
However,
neural
mechanisms
underlying
influence
on
feeding
remain
poorly
understood.
this
study,
we
demonstrate
treatment
effectively
reduces
food
intake
and
mitigates
weight
gain
mice
through
circuit
involving
lateral
hypothalamic
area
(LHA).
Specifically,
subset
SMI-32-expressing
ON-type
retinal
ganglion
cells
(RGCs)
innervate
GABAergic
neurons
ventral
geniculate
nucleus
(vLGN),
which
turn
inhibits
LHA.
Activation
both
vLGN-projecting
RGCs
vLGN-to-LHA
pathway
is
sufficient
suppress
consumption
attenuate
gain.
Importantly,
provide
direct
suppressive
effects
rely
activation
retina-vLGN-LHA
pathway.
Together,
our
results
delineate
an
LHA-related
consumption-suppressing
gain-attenuating
treatment.
Язык: Английский
Neural-circuit architecture underlying non-image-forming visual functions
Current Opinion in Neurobiology,
Год журнала:
2025,
Номер
93, С. 103052 - 103052
Опубликована: Май 24, 2025
Язык: Английский