Assembloid models of cell-cell interaction to study tissue and disease biology
Cell stem cell,
Год журнала:
2024,
Номер
31(11), С. 1563 - 1573
Опубликована: Окт. 24, 2024
Язык: Английский
Modelling human brain development and disease with organoids
Nature Reviews Molecular Cell Biology,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 12, 2024
Язык: Английский
Organoid intelligence for developmental neurotoxicity testing
Dowlette-Mary Alam El Din,
Jeongwon Shin,
Alexandra Lysinger
и другие.
Frontiers in Cellular Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Окт. 8, 2024
The
increasing
prevalence
of
neurodevelopmental
disorders
has
highlighted
the
need
for
improved
testing
methods
to
determine
developmental
neurotoxicity
(DNT)
hazard
thousands
chemicals.
This
paper
proposes
integration
organoid
intelligence
(OI);
leveraging
brain
organoids
study
neuroplasticity
in
vitro,
into
DNT
paradigm.
OI
brings
a
new
approach
measure
impacts
xenobiotics
on
plasticity
mechanisms
–
critical
biological
process
that
is
not
adequately
covered
current
vitro
assays.
Finally,
artificial
(AI)
techniques
will
further
facilitate
analysis
complex
data
these
mechanisms.
Язык: Английский
Assessing the Utility of Organoid Intelligence: Scientific and Ethical Perspectives
Organoids,
Год журнала:
2025,
Номер
4(2), С. 9 - 9
Опубликована: Май 1, 2025
The
development
of
brain
organoids
from
human-induced
pluripotent
stem
cells
(iPSCs)
has
expanded
research
into
neurodevelopment,
disease
modeling,
and
drug
testing.
More
recently,
the
concept
organoid
intelligence
(OI)
emerged,
proposing
that
these
constructs
could
evolve
to
support
learning,
memory,
or
even
sentience.
While
this
perspective
driven
enthusiasm
in
field
suggested
new
applications
fields
such
as
neuromorphic
computing,
it
also
introduces
significant
scientific
conceptual
concerns.
Current
lack
anatomical
complexity,
network
organization,
sensorimotor
integration
necessary
for
Despite
this,
claims
surrounding
OI
often
rely
on
oversimplified
interpretations
neural
activity,
fueled
by
neurorealist
reification
biases
misattribute
neurophysiological
properties
biologically
limited
systems.
Beyond
limitations,
framing
risks
imposing
ethical
regulatory
challenges
based
speculative
concerns
rather
than
empirical
evidence.
assumption
might
possess
sentience,
develop
over
time,
lead
unnecessary
restrictions
legitimate
while
misrepresenting
their
actual
capabilities.
Additionally,
comparing
biological
systems
silicon-based
computing
overlooks
fundamental
differences
scalability,
efficiency,
predictability,
raising
questions
about
whether
can
meaningfully
contribute
computational
advancements.
must
recognize
limitations
models
prematurely
defining
a
distinct
domain.
A
more
cautious,
evidence-driven
approach
is
ensure
remain
valuable
tools
neuroscience
without
overstating
potential.
To
maintain
credibility
public
trust,
essential
separate
narratives
grounded
research,
thus
allowing
continued
progress
studies
reinforcing
misconceptions
Язык: Английский
Protocol for generating human assembloids to investigate thalamocortical and corticothalamic synaptic transmission and plasticity
STAR Protocols,
Год журнала:
2025,
Номер
6(1), С. 103630 - 103630
Опубликована: Фев. 7, 2025
Язык: Английский
Modeling forebrain regional development and connectivity by human brain organoids
Current Opinion in Genetics & Development,
Год журнала:
2025,
Номер
91, С. 102324 - 102324
Опубликована: Фев. 20, 2025
Язык: Английский
Role of Post-Transcriptional Regulation in Learning and Memory in Mammals
Genes,
Год журнала:
2024,
Номер
15(3), С. 337 - 337
Опубликована: Март 5, 2024
After
many
decades,
during
which
most
molecular
studies
on
the
regulation
of
gene
expression
focused
transcriptional
events,
it
was
realized
that
post-transcriptional
control
equally
important
in
order
to
determine
where
and
when
specific
proteins
were
be
synthesized.
Translational
is
importance
brain,
all
steps
mRNA
maturation,
transport
different
regions
cells
actual
expression,
response
signals,
constitute
basis
for
neuronal
plasticity
and,
as
a
consequence,
structural
stabilization/modification
synapses;
notably,
these
latter
events
are
fundamental
highest
brain
functions,
such
learning
memory,
characterized
by
long-term
potentiation
(LTP)
synapses.
Here,
we
will
discuss
bases
considering
both
role
RNA-binding
(RBPs)
effects
non-coding
RNAs
involved
controlling
splicing,
editing,
stability
translation
mRNAs.
Importantly,
has
also
been
found
dysregulation
metabolism/localization
pathological
conditions,
arising
either
development
or
adult
nervous
system.
Язык: Английский
Human pluripotent stem cell (hPSC)-derived models for autism spectrum disorder drug discovery
Expert Opinion on Drug Discovery,
Год журнала:
2024,
Номер
unknown, С. 1 - 19
Опубликована: Дек. 24, 2024
Autism
spectrum
disorder
(ASD)
is
a
prevalent
and
complex
neurodevelopmental
(NDD)
with
genetic
environmental
origins.
Currently,
there
are
no
effective
pharmacological
treatments
targeting
core
ASD
features.
This
leads
to
unmet
medical
needs
of
individuals
requires
relevant
human
disease
models
recapitulating
clinical
heterogeneity
better
understand
underlying
mechanisms
identify
potential
therapies.
Recent
advancements
in
stem
cell
technology
have
enabled
the
generation
pluripotent
(hPSC)-derived
two-dimensional
(2D)
three-dimensional
(3D)
neural
models,
which
serve
as
powerful
tools
for
modeling
drug
discovery.
Язык: Английский