Ferroptosis: A Targetable Vulnerability for Melanoma Treatment

Journal of Investigative Dermatology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Melanoma is a devastating form of skin cancer characterized by high mutational burden, limited treatment success, and dismal prognosis. Although immunotherapy targeted therapies have significantly revolutionized melanoma treatment, the majority patients fail to achieve durable responses, highlighting urgent need for novel therapeutic strategies. Ferroptosis, an iron-dependent regulated cell death driven overwhelming accumulation lipid peroxides, has emerged as promising approach in preclinical models. A deeper understanding ferroptosis landscape based on its biology characteristics, including phenotypic plasticity, metabolic state, genomic alterations, epigenetic changes, well complex role mechanisms immune cells could provide foundation developing effective treatments. In this review, we outline molecular ferroptosis, decipher regulation, reveal potential melanoma, discuss pressing questions that should guide future investigations into melanoma.

Язык: Английский

Sodium aescinate induces hepatotoxicity through apoptosis and ferroptosis by inhibiting the Nrf2/CTH pathway

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119608 - 119608

Опубликована: Март 1, 2025

Язык: Английский