Maternal Immune-Mediated Conditions and ADHD Risk in Offspring
Опубликована: Апрель 14, 2025
Abstract
BACKGROUND
Maternal
immune-mediated
conditions
during
pregnancy
have
been
linked
with
increased
risk
of
attention-deficit/hyperactivity
disorder
(ADHD)
in
offspring.
However,
we
do
not
know
the
extent
to
which
these
associations
are
influenced
by
shared
genetic
predispositions,
as
opposed
maternal
inflammatory/immune
responses
pregnancy.
This
study
contributes
using
paternal
a
negative
control
explore
underlying
factors,
investigate
between
and
offspring
ADHD.
METHODS
Prospective
data
from
Norwegian
Mother,
Father,
Child
Cohort
Study
(MoBa)
was
Medical
Birth
Registry
Norway
(MBRN)
Patient
(NPR)
assess
prenatal
exposure
ADHD
up
age
18.
Nationwide
recruitment
1999
2008
resulted
104,270
eligible
mother-child
pairs.
Among
these,
21,340
children
were
exposed
allergic
(asthma,
allergies,
atopic
conditions)
7,478
other
immune
(autoimmune,
inflammatory).
Paternal
self-reported
served
controls
for
confounding.
Data
mostly
collected
through
MoBa,
additional
condition
cases
sourced
MBRN,
children’s
diagnoses
obtained
NPR.
Cox
proportional
hazard
models
estimated
Hazard
ratios
diagnoses.
RESULTS
Both
overall
categories
associated
(allergic
HR
1.23
95%
CI,
1.14–1.34;
1.36
1.21–1.53).
Specifically,
found
asthma
(HR
1.47
1.30–1.67);
allergies
1.20
1.10–1.31);
rheumatologic/musculoskeletal
1.64
1.28–2.10),
Crohn’s
disease/ulcerative
colitis
(adjusted
1.95
1.23–3.09),
endocrine
1.42
1.15–1.77),
specifically,
type
1
diabetes
2.50
1.66–3.75).
Although
some
(psoriasis,
ulcerative
colitis,
disease)
showed
similar
trends
offspring,
only
significantly
1.26
1.10–1.45).
CONCLUSIONS
Several
Observations
higher,
more
consistent
estimates
most
versus
ones
indicate
that
unmeasured
confounding
does
fully
explain
associations.
These
results
suggest
direct
effects
on
fetal
development
events
at
maternal-fetal
interface
may
alter
potentially
lead
greater
Asthma
be
possible
exception
this
mechanism,
also
Язык: Английский
Maternal immune activation and neuropsychiatric disease in offspring: Pathogen's perspective
Zhiyang Yin,
Catherine Gordon,
Zikai Zhou
и другие.
Decoding Infection and Transmission,
Год журнала:
2024,
Номер
2, С. 100029 - 100029
Опубликована: Янв. 1, 2024
Язык: Английский