The Roles of Distinct Transcriptional Factors in the Innate Immunity of C. elegans

Cells, Год журнала: 2025, Номер 14(5), С. 327 - 327

Опубликована: Фев. 21, 2025

Deleterious molecules or factors produced by pathogens can hinder the normal physiological functioning of organisms. In response to these survival challenges, organisms rely on innate immune signaling as their first line defense, which regulates immune-responsive genes and antimicrobial peptides protect against pathogenic infections. These are under control transcription factors, known regulate transcriptional activity after binding regulatory sequences. Previous studies have employed Caenorhabditis elegans a host-pathogen interaction model demonstrate essential role different in immunity worms. this review, we summarize advances made regarding distinct upon pathogen infection. Finally, discuss open questions field, whose resolutions potential expand our understanding mechanisms underlying

Язык: Английский

Patterns of pathogenesis in innate immunity: insights from C. elegans

Nature reviews. Immunology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 17, 2025

Язык: Английский